Visual acuity of dentists under simulated clinical conditions.

Objectives: This study examined the near visual acuity of dentists in relation to age and magnification under simulated clinical conditions.

Materials And Methods: Miniaturized visual tests were performed in posterior teeth of a dental phantom head in a simulated clinical setting (dental chair, operating lamp, dental mirror). The visual acuity of 40 dentists was measured under the following conditions: (1) natural visual acuity, distance of 300 mm; (2) natural visual acuity, free choice of distance; (3) Galilean loupes, magnification of ×2.

Comparison between a guaiac and three immunochemical faecal occult blood tests in screening for colorectal cancer.

Background: The aim of this study was to compare the performance of the guaiac-based faecal occult blood test (G-FOBT), with that of three immunochemical faecal occult blood tests (I-FOBT) which allow automatic interpretation.

Patients And Methods: Under the French organised screening programme, 85,149 average-risk individuals aged 50-74 participating in the third screening round, performed both the G-FOBT (Hemoccult-II test) and one of the I-FOBTs: FOB-Gold, Magstream and OC-Sensor.

Results: Given the chosen threshold, the positivity ratio between the different I-FOBTs and the G-FOBT was 2.

Indication of reactor ν(e) disappearance in the Double Chooz experiment.

The Double Chooz experiment presents an indication of reactor electron antineutrino disappearance consistent with neutrino oscillations. An observed-to-predicted ratio of events of 0.944±0.

[Prostate-specific antigen use among men without prostate cancer in France (2008-2010)].

This study evaluated the rate of prostate-specific antigen (PSA) dosage in men age 40 or older, affiliated to the general social security system in France between 2008 and 2010: 10.9 million men, excluding those with known prostate cancer. In 2010, 30.

Specific injuries induced by the practice of trampoline, tumbling and acrobatic gymnastics.

Purpose: The recreational and competitive practice of acrobatic sports, that is, trampoline, tumbling and acrobatic gymnastics (ACRO), is growing rapidly around the world. Many studies described the injuries affecting young artistic gymnasts, but only few concerned acrobatic sports.

Methods: During a 5-year period, 357 traumatic events were collected in young acrobats practicing trampoline, tumbling or ACRO.

Role of plasma exchange in the thyroid storm.

Inadequately treated thyroid storm can lead to death. Therapeutic plasma exchange (TPE) is a suggested treatment when conventional treatments fail, but its indication is not well codified. We report our experience through three explicit cases.

Measurement of adenoma detection and discrimination during colonoscopy in routine practice: an exploratory study.

Background: Measuring neoplasia yield is a priority in the quality improvement process for colonoscopy. However, neither the most appropriate quality indicator nor the standard threshold has been established.

Objective: To determine the most appropriate quality indicators to assess the yield of routine colonoscopy.

High-frequency skull vibration-induced nystagmus test in partial vestibular lesions.

Objectives: To establish the effectiveness of the skull vibration-induced nystagmus test (SVINT) as a rapid high-frequency stimulation test, in the evaluation of partial unilateral vestibular lesions (pUVL).

Methods: SVINT (30, 60, and 100 Hz), caloric, and head-shaking tests were performed in 99 patients with pUVL. These results were compared with those in 9 patients with symmetrical partial bilateral labyrinthine malformations, 131 patients with total unilateral vestibular lesions (tUVL), and 95 control subjects.

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research.

CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated phosphorylation event is still insufficient to recognize it as a clinically validated target. CIGB-300, an investigational peptide-based drug that targets the phosphoaceptor site, binds to a CK2 substrate array in vitro but mainly to B23/nucleophosmin in vivo.

Biopsy and treatment decisions in the initial management of prostate cancer and the role of PCA3; a systematic analysis of expert opinion.

Purpose: The Prostate CAncer gene 3 (PCA3) assay may guide prostate biopsy decisions and predict prostate cancer (PCa) aggressiveness. This study explored the appropriateness of (1) PCA3 testing; (2) biopsy; (3) active surveillance (AS) and the value of the PCA3 Score for biopsy and AS decisions.

Methods: Using the RAND/UCLA appropriateness method, 12 urologists assessed the appropriateness of PCA3, biopsy and AS for theoretical patient profiles, constructed by combining clinical variables.

[How to select the best candidates for prostate biopsies? The role of traditional tools and contribution of new biomarkers in prostate cancer].

In 2010, early detection of prostate cancer continues to rely on digital rectal examination and serum total PSA. However, selecting patients for prostate biopsy requires taking into account the prostate volume and the evolution of PSA over time. PSA derivatives such as PSA density, PSA velocity and the ratio free PSA / total PSA are useful supplements.

Management of postural sensory conflict and dynamic balance control in late-stage Parkinson's disease.

Parkinson's disease (PD) is known to affect postural control, especially in situations needing a change in balance strategy or when a concurrent task is simultaneously performed. However, few studies assessing postural control in patients with PD included homogeneous population in late stage of the disease. Thus, this study aimed to analyse postural control and strategies in a homogeneous population of patients with idiopathic advanced (late-stage) PD, and to determine the contribution of peripheral inputs in simple and more complex postural tasks, such as sensory conflicting and dynamic tasks.

Stocktaking on the development of posturography for clinical use.

This report identifies fundamental problems to be addressed in order to build relevant clinical tests of human balance while standing. The stated purpose of these tests is identification of lesion site and/or definition of functional balance deficits in a specific patient. During a recent consensus meeting (ESCEBD), 60 researchers and experienced clinical users of posturography (14 European countries, 9 different disciplines) inventoried and critically analyzed the various methodologies of posturography currently used for clinical evaluation.

Drug-resistant temporal lobe epilepsy is associated with postural control abnormalities.

Epilepsy is responsible for falls that are not systematically associated with seizures and that therefore suggest postural impairment. There are very few studies of postural control in patients with epilepsy and none of them focus on temporal lobe epilepsy (TLE), although part of the vestibular cortex is located in the temporal cortex. The aim of this study was to evaluate the characteristics of postural control in a homogeneous population of patients with complex partial TLE.

[Value of PCA3 urinary test for prostate biopsy decision: the Lyon-Sud University Hospital experience].

The poor specificity of diagnostic strategy for prostate cancer (digital rectal examination and seric PSA) induces both a great number of useless prostate biopsies and diagnosis of non evolutive cancers. A urinary test (Progensa PCA3(®), Gen-Probe) measuring the expression of PCA3, a prostate cancer-specific gene, has recently be proposed to indicate re-biopsy. The aim of this prospective study was to evaluate diagnostic value of urinary PCA3 test for prostate cancer.

Influence of loupes and age on the near visual acuity of practicing dentists.

We evaluated the near visual acuity of 40 dentists and its improvement by using different magnification devices. The acuity was tested with miniaturized E-optotype tests on a negatoscope under the following conditions: 1. natural visual acuity, 300 mm; 2.

Incidence and risk factors of glucose metabolism disorders in kidney transplant recipients: role of systematic screening by oral glucose tolerance test.

Background: New-onset diabetes after transplantation (NODAT) increases infectious and cardiovascular complications and reduces patient and graft survival. We assessed the incidence and the risk factors for glucose metabolism abnormalities before and after kidney transplantation using an oral glucose tolerance test (OGTT). The purpose of the study was to better identify patients at risk for NODAT to adapt their immunosuppressive treatment and their management after transplantation.

Postural instability in early-stage idiopathic scoliosis in adolescent girls.

Study Design: Cross-sectional study.

Objective: To evaluate whether the amplitude of spine deformation in adolescent idiopathic scoliosis (AIS) is an important factor for postural control at disease onset.

Summary Of Background Data: AIS is related to disorders of postural control with potential involvement of vestibular, proprioceptive, and visual input.

Caregiver mental health and racial/ethnic disparities in stroke: implications for culturally sensitive interventions.

Purpose/objective: The purpose of this study was to create a set of culturally sensitive mental-health-intervention recommendations for the caregivers of Latino/Puerto-Rican, Black, and White individuals with stroke. The study examined whether the mental health of stroke caregivers and functioning of individuals with stroke differed according to race/ethnicity, changed differentially over time according to race/ethnicity, and showed relationships between the two sets of constructs that differed according to race/ethnicity.

Research Method/design: Data on caregiver mental health and functioning of individuals with stroke were collected from 124 (n = 248) White, Black, and Latino/Puerto-Rican dyads at 1, 6, and 12 months post-hospital discharge.

Xmn I polymorphism associated with concomitant activation of Gγ and Aγ globin gene transcription on a β0-thalassemia chromosome.

The -158 (C→T) nucleotide change, known as Xmn I polymorphism, occurs in (G)γ-globin gene promoter, and results in elevated fetal hemoglobin (HbF). We found this mutation in cis of a β(0)-thalassemia splicing mutation. Despite the complete absence of adult HbA, the phenotype was only moderately severe with no detectable alteration of α-globin gene expression.

A culturally sensitive Transition Assistance Program for stroke caregivers: examining caregiver mental health and stroke rehabilitation.

This study developed and implemented the Transition Assistance Program (TAP) for stroke caregivers. The program is composed of (1) skill development, (2) education, and (3) supportive problem solving. Sixty-one dyads (n = 122) participated: thirty-nine from Puerto Rico and twenty-two from Texas.

Some diminutive colorectal polyps can be removed and discarded without pathological examination.

Background And Study Aims: Pathological examination of colorectal polyps is useful if clinical management is affected (i. e. when invasive carcinoma is detected or postpolypectomy surveillance interval is guided).

Pre-operative vestibular pattern and balance compensation after vestibular schwannoma surgery.

This longitudinal study aimed to assess the sensorimotor balance strategies before and after vestibular schwannoma (VS) surgery according to the degree of pre-operative vestibular lesion. Thirty-eight VS patients were split in three groups according to caloric vestibular test results before surgery; nine had a symmetrical vestibular response (vestibular normoreflexy), 19 with a decreased response of more than 20% of the affected side (vestibular hyporeflexy) and 10 with an absent caloric response on the side of the affected labyrinth (vestibular areflexy). They underwent pendular rotary vestibular testing (RVT), allowing to evaluate gain and directional preponderance of the vestibulo-ocular reflex, and a sensory organisation test (SOT), evaluating balance control in six conditions (C1 to C6).

Light-responsiveness of C12E6/polymer complexes swollen with dodecane.

The association behavior of light-responsive azobenzene modified poly(sodium acrylate)s (AMPs) with C(12)E(6) (hexa-oxyethyleneglycol n-dodecyl ether) surfactant micelles swollen with dodecane was investigated using dynamic light scattering, UV spectrophotometry, and capillary electrophoresis techniques. AMPs complexes with oligoethyleneglycol n-alkyl ether show promising properties as emulsifiers for the light-triggered control of inversion of emulsions and the present work aims at giving new insights with respect to the nature of their photoresponse. Depending on the dodecane amount, the size of the spherical surfactant micelles was varied with radii ranging from 4 to 8 nm.