Long-term follow-up of efficacy and safety of selinexor maintenance treatment in patients with TP53wt advanced or recurrent endometrial cancer: A subgroup analysis of the ENGOT-EN5/GOG-3055/SIENDO study.

Objective: To report long-term efficacy and safety of selinexor maintenance therapy in adults with TP53 wild-type (TP53wt) stage IV or recurrent endometrial cancer (EC) who achieved partial remission (PR) or complete remission (CR) following chemotherapy.

Methods: Analysis of the prespecified, exploratory subgroup of patients with TP53wt EC from the phase 3 SIENDO study was performed. Progression-free survival (PFS) benefit in patients with TP53wt EC and across other patient subgroups were exploratory endpoints.

Prophylactic salpingectomy with delayed oophorectomy as a two-staged alternative for primary prevention of ovarian cancer in BRCA1/2 mutation carriers: women's point of view.

Objective: This study aimed to determine BRCA -mutation carrier women's interest and acceptability of participating in a study examining prophylactic salpingectomy with delayed oophorectomy (PSDO) as an alternative to the current recommendation for bilateral salpingo-oophorectomy for risk reduction.

Methods: This is a cross-sectional questionnaire-based study. All women visiting the high-risk clinics for hereditary breast and ovarian cancer in a single tertiary medical center were asked to complete a questionnaire concerning the two-stage approach from October 2018 to December 2019.

Ethnic disparity in cervical cancer stage at diagnosis: A retrospective study in an Israeli referral-center.

Objective: To compare stage and survival of cervical cancer between Jewish and Arab women in a tertiary medical center in Israel.

Methods: Retrospective study of consecutive women diagnosed with cervical cancer in a single institution between 2010 and 2021. We compared Jewish and Arab patients using univariate, multivariable, and survival curves analysis.

Prototype Machine Learning Algorithms from Wearable Technology to Detect Tennis Stroke and Movement Actions.

This study evaluated the accuracy of tennis-specific stroke and movement event detection algorithms from a cervically mounted wearable sensor containing a triaxial accelerometer, gyroscope and magnetometer. Stroke and movement data from up to eight high-performance tennis players were captured in match-play and movement drills. Prototype algorithms classified stroke (i.

Proteomic signature for detection of high-grade ovarian cancer in germline BRCA mutation carriers.

No current screening methods for high-grade ovarian cancer (HGOC) guarantee effective early detection for high-risk women such as germline BRCA mutation carriers. Therefore, the standard-of-care remains risk-reducing salpingo-oophorectomy (RRSO) around age 40. Proximal liquid biopsy is a promising source of biomarkers, but sensitivity has not yet qualified for clinical implementation.

Ovarian cancer risk management in BRCA-mutation carriers: A comparison of six international and national guidelines.

Objective: Germline mutations in the BRCA gene account for most hereditary ovarian and breast cancer. Management of healthy carriers aims to prevent and allow early detection of breast and ovarian cancer. This study compares six different hereditary ovarian cancer management guidelines, highlighting areas of controversy between different societies.

Differentiating Stroke and Movement Accelerometer Profiles to Improve Prescription of Tennis Training Drills.

Perri, T, Reid, M, Murphy, A, Howle, K, and Duffield, R. Differentiating stroke and movement accelerometer profiles to improve prescription of tennis training drills. J Strength Cond Res 37(3): 646-651, 2023-This study compared the movement- and stroke-related accelerometer profiles and stroke counts between common on-court tennis training drills.

Determining Stroke and Movement Profiles in Competitive Tennis Match-Play From Wearable Sensor Accelerometry.

Perri, T, Reid, M, Murphy, A, Howle, K, and Duffield, R. Determining stroke and movement profiles in competitive tennis match-play from wearable sensor accelerometry. J Strength Cond Res 37(6): 1271-1276, 2023-This study determined stroke and movement accelerometry metrics from a wearable sensor and compared between court surface (grass vs.

Sentinel lymph node mapping in endometrial cancer: A comparison of main national and international guidelines.

Objectives: To compare national and international guidelines regarding sentinel lymph node (SLN) mapping in endometrial cancer.

Methods: A descriptive comparative study of the National Comprehensive Cancer Network (NCCN), the Society of Gynecologic Oncology (SGO), the European Society of Gynecological Oncology (ESGO), the British Gynecological Cancer Society (BGCS), and the Japan Society of Gynecologic Oncology (JSGO) guidelines.

Results: There is a broad consensus that SLN mapping is an appropriate alternative to pelvic lymphadenectomy for uterine-confined endometrioid endometrial cancer (five of five guidelines).

Validating an algorithm from a trunk-mounted wearable sensor for detecting stroke events in tennis.

This study analysed the accuracy of a prototype algorithm for tennis stroke detection from wearable technology. Strokes from junior-elite tennis players over 10 matches were analysed. Players wore a GPS unit containing an accelerometer, gyroscope and magnetometer.

The impact of olaparib dose reduction and treatment interruption on treatment outcome in the SOLO2/ENGOT-ov21 platinum-sensitive recurrent ovarian cancer.

Background: Maintenance treatment with poly (ADP-ribose) polymerase (PARP) inhibitor is now the standard of care in patients with BRCA-mutated platinum-sensitive recurrent ovarian cancer following response to chemotherapy. In the SOLO2 trial, adverse event (AE)-associated olaparib interruption, dose reduction, and discontinuation occurred in 50%, 28%, and 17% of patients, respectively. We used data from the SOLO2 trial to evaluate the impact of dose alterations on survival outcomes and identified baseline characteristics associated with dose alteration.

Early prediction of urinary retention following radical hysterectomy by 18F-FDG PET/CT imaging.

Background: Radical hysterectomy for early cervical cancer is associated with postoperative bladder dysfunction. Postoperative imaging by F-FDG PET/CT scanning is often performed to rule out recurrence. Since women are instructed to empty the bladder before imaging, we aim to study if scanned abnormal residual bladder volume is associated with future urinary symptoms.

Minimally invasive approach in endometrial cancer with lower uterine segment involvement in stage ≥ II: A retrospective study.

Objective: To compare oncological outcomes in women with lower uterine segment involvement (LUSI) in endometrial carcinoma (EC) stage ≥ II - staged by a minimally invasive surgery (MIS) versus laparotomy.

Study Design: A retrospective multi-center cohort study. Univariate analysis, Kaplan-Meier survival and Cox proportional hazard analysis were performed to compare between women staged by MIS and those staged by laparotomy.

Risk-reducing salpingo-oophorectomy and breast cancer incidence among Jewish BRCA1/BRCA2-mutation carriers-an Israeli matched-pair study.

Objective: To study the association of risk-reducing bilateral salpingo-oophorectomy (RRBSO) and breast cancer risk among BRCA pathogenic sequence variants (PSV).

Methods: Jewish Israeli BRCA carriers who underwent RRBSO were matched with those who did not-by the mutated gene and year of birth (±1 year). Breast cancer rates were compared.

Spontaneous versus morcellator-related benign metastasizing leiomyoma-A retrospective study.

Objective: To compare characteristics, disease course, and prognosis of spontaneous versus iatrogenic benign metastasizing leiomyoma (BML).

Methods: A retrospective cohort study comparing iatrogenic and spontaneous BML.

Results: Twenty cases were included, 12 (60%) spontaneous and 8 (40.

Competition scheduling patterns of emerging elite players in professional men's tennis.

This study analysed the competition scheduling of future top 100 and 250 ranked tennis players from international tournament profiles at ages 13-18y. Retrospective tournament data were analysed for 165 future top 100 (T100) and top 250 (T250) males during their junior international tournament eligibility. Tournament/match volumes, days between tournaments and consecutive tournaments (<8 days between) were quantified for junior and professional events.

Fertility treatments and breast cancer risk in Jewish Israeli BRCA mutation carriers.

Objective: To determine whether fertility treatments impact the risk of breast cancer in Jewish Israeli BRCA1/2 mutation carriers.

Design: Historical cohort study.

Setting: University-affiliated tertiary medical center.

Frequency and prediction of deep uterine involvement in advanced high-grade epithelial ovarian cancer: is uterine preservation an option?

Introduction: Hysterectomy is traditionally part of the surgical treatment for advanced high-grade epithelial ovarian carcinomas, although the incidence of uterine involvement has not been fully investigated. Some young patients with advanced high-grade epithelial ovarian carcinomas want uterine preservation. We aimed to determine the frequency of non-serosal (deep) uterine involvement in patients with high-grade epithelial ovarian carcinomas and to establish predictive factors for such involvement.

Time interval from biopsy to surgery and risk for adjuvant therapy in patients with low-risk endometrial cancer.

Objective: Among patients with endometrial cancer, longer wait times to surgery were associated with decreased survival. Although endometrial cancer survival rate is high, about 45% of patients receive adjuvant therapy. The aim of this study was to examine whether a longer interval from diagnosis to surgery is associated with increased need for adjuvant treatment among patients with low-risk endometrial cancer.

Brain Metastases from Ovarian Carcinoma: An Evaluation of Prognostic Factors and Treatment.

Aims And Objectives: To review a series of patients with brain metastases from ovarian cancer at a single institution. To describe treatment modalities, their outcomes and to determine prognostic factors.

Patients And Methods: Between January 1995 and December 2014, 25 patients with ovarian cancer brain metastases were treated at The Sheba Medical Center.

Menopausal hormone therapy for BRCA-mutation carriers: attitudes of Israeli healthcare providers before and after a brief educational intervention.

Objective: BRCA-mutation carriers are offered risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 35 to 40 years, leading to major life-quality and health-related issues associated with early menopause. Hormone therapy (HT) may significantly alleviate menopausal symptoms without increasing breast or ovarian cancer risk in BRCA carriers. We investigated attitudes of Israeli healthcare providers to HT post-RRBSO in BRCA carriers, before and after a brief educational intervention.