Masticatory performance, self-perception of oral health, oral health-related quality of life and nutritional status of completely edentulous elderly patients submitted to different rehabilitation treatments: A cross-sectional study.

Background: The impact of treatments on completely edentulous individuals on masticatory performance (MP), oral health-related quality of life (OHRQoL), nutritional status (NS) and socio-economic profile (SP) is unclear in the literature.

Objective: To compare the MP, OHRQoL, NS and SP of totally edentulous elderly users of bimaxillary complete dentures (CD) and users of lower implant-supported fixed complete dentures (IFCD).

Methods: Forty participants were allocated into groups according to rehabilitation treatment (n = 20): bimaxillary CD (G1) and lower IFCD, and upper CD (G2).

Phenotypic complexities of rare heterozygous neurexin-1 deletions.

Given the large number of genes significantly associated with risk for neuropsychiatric disorders, a critical unanswered question is the extent to which diverse mutations --sometimes impacting the same gene-- will require tailored therapeutic strategies. Here we consider this in the context of rare neuropsychiatric disorder-associated copy number variants (2p16.3) resulting in heterozygous deletions in , a pre-synaptic cell adhesion protein that serves as a critical synaptic organizer in the brain.

Microbial adhesion and biofilm formation by Candida albicans on 3D-printed denture base resins.

This study evaluated surface properties and adhesion/biofilm formation by Candida albicans on 3D printed denture base resins used in 3D printing. Disc-shaped specimens (15 mm x 3 mm) of two 3D-printed resins (NextDent Denture 3D+, NE, n = 64; and Cosmos Denture, CO, n = 64) and a heat-polymerized resin (Lucitone 550, LU, control, n = 64) were analyzed for surface roughness (Ra μm) and surface free energy (erg cm-2). Microbiologic assays (90-min adhesion and 48-h biofilm formation by C.

Synaptojanin 1 Modulates Functional Recovery After Incomplete Spinal Cord Injury in Male Apolipoprotein E Epsilon 4 Mice.

Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ∼14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for poor outcomes after traumatic spinal cord injury (SCI) and spinal cord diseases such as cervical myelopathy. To date, there is no intervention to promote recovery of function after SCI/spinal cord diseases that is specifically targeted at ApoE4-associated impairment.

Effectiveness of disinfectant solutions associated or not with brushing on the biofilm control of a 3D printed-denture base resin.

Background: The formation of biofilm on denture bases is a recurrent clinical problem that favors the development of denture stomatitis. The effectiveness of a hygiene protocol in a 3D-printed denture base resin is still uncertain.

Objective: To evaluate of the effectiveness of immersion, associated or not with brushing in a soap solution, on the biofilm control of a 3D-printed denture base resin.

Effect of immersion in disinfectants on the color stability of denture base resins and artificial teeth obtained by 3D printing.

Purpose: To evaluate the effect of immersion in disinfecting solutions on the color stability of denture base resins and artificial teeth obtained by 3D printing.

Materials And Methods: Forty discs (15 × 3 mm) were obtained for each group: Lucitone 550 and Cosmos Denture 3D (denture base resins), Duralay and Cosmos TEMP 3D (artificial teeth resins). The discs were immersed in disinfectant solutions: Corega Tabs, 2% chlorhexidine digluconate, 0.

Is It Reasonable to Expect Students and Trainees to Internalize Equity as a Core Professional Value When Teaching and Learning Occurs in Segregated Settings?

Training in a segregated health care system means that health professions students and trainees learn bias and experience helplessness and burnout if they wish to-but cannot-rectify segregated care. When racial segregation is built into training environments, many students and trainees quickly internalize which patients are de facto deemed more worthy of care. Students and trainees who recognize this feature of their professional training as dysfunctional and as an ethical and equity problem need support when reporting inequities and advocating for desegregated health systems.

Effect of repair methods and materials on the flexural strength of 3D-printed denture base resin.

Purpose: The aim of this study was to evaluate the flexural strength of a 3D-printed denture base resin (Cosmos Denture), after different immediate repair techniques with surface treatments and thermocycling.

Materials And Methods: Rectangular 3D-printed denture base resin (Cosmos Denture) specimens (N = 130) were thermocycled (5,000 cycles, 5℃ and 55℃) before and after the different repair techniques (n = 10 per group) using an autopolymerized acrylic resin (Jet, J) or a hard relining resin (Soft Confort, SC), and different surface treatments: Jet resin monomer for 180 s (MMA), blasting with aluminum oxide (JAT) or erbium: yttrium-aluminum-garnet laser (L). The control group were intact specimens.

Triptan medication use among patients with migraine with contraindications in the US.

Objective: We sought to investigate the prevalence of triptan use among patients with migraine who have contraindications to triptan usage, and to explore specifics of the medication prescribed, dosage, and route of administration.

Background: Triptan medications are a mainstay of acute migraine therapy, but little is known about prevalence and patterns of triptan prescribing among patients with contraindications in the United States.

Methods: In this retrospective cohort study, we used data from the IBM Marketscan database to identify patients aged ≥ 18 years with migraine from January 1, 2016, to December 31, 2017, using International Classification of Diseases, Clinical Modification 10 codes.

Evaluation of Shear Bond Strength Between Denture Teeth and 3D-Printed Denture Base Resin.

Purpose: The aim of this study was to evaluate the bond strength between two types of artificial teeth with a 3D-printed denture base resin using different bonding agents.

Materials And Methods: Two types of artificial teeth were evaluated: 3D-printed (Cosmos TEMP) and prefabricated polymethylmethacrylate (Biotone) bonded to cylinders (2.5 mm in height and 5 mm in diameter) of 3D-printed denture bases (Cosmos Denture designing by Meshmixer and printed by Flashforge Hunter DLP Resin 3D Printer).

Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients.

Background: Several articles reported the existence of an association between ABO blood groups and COVID-19 susceptibility. Group A and group O individuals showed a higher and lower risk, respectively, of becoming infected. No association was observed between ABO groups and mortality.

COVID-19: A Perspective from Clinical Neurology and Neuroscience.

Despite the increasing large population of COVID-19 infected patients, knowledge of the disease remains limited. Understanding the effects and long-term implications of COVID-19 will be paramount to implementing the right public health measures and developing future preventive and effective treatments. In this article, we discuss currently available information with COVID-19-related neurological complications, possible routes of virus infection into the central nervous system, and hypothesis about virus-induced cytokine storm syndrome, long-term outcomes, as well as ongoing clinical studies of novel therapies and biomarkers for COVID-19.

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.

Our recent findings link the apolipoprotein E4 (ApoE4)-specific changes in brain phosphoinositol biphosphate (PIP) homeostasis to the susceptibility of developing Alzheimer's Disease (AD). In the present study, we have identified miR-195 as a top micro-RNA candidate involved in the ApoE/PIP pathway using miRNA profiles in human ROSMAP datasets and mouse microarray studies. Further validation studies have demonstrated that levels of miR-195 are significantly lower in human brain tissue of ApoE4 patients with clinical diagnosis of mild cognitive impairment (MCI) or early AD when compared to ApoE4 subjects.

Influence of adhesives usage in complete dentures during adaptation period varying the degree of resorption of mandibular ridges.

Purpose: This study evaluated the effect of the use of a powder-type adhesive on masticatory performance and oral health related quality of life (OHRQoL) in patients with normal and resorbed mandibular ridges during adaptation period with complete dentures.

Methods: Forty-two edentulous subjects (12 men, 30 women) were distributed in four groups: normal mandibular ridges with adhesive, n = 10; normal mandibular ridges without adhesive, n = 10; resorbed mandibular ridges with adhesive, n = 11; resorbed mandibular ridges without adhesive, n = 11. Masticatory performance was evaluated by sieving method and OHRQoL by Oral Health Impact Profile in Edentulous Adults (OHIP-EDENT) inventory at 30, 60 and 90 days after the insertion of new complete dentures.

Masticatory function in complete denture wearers varying degree of mandibular bone resorption and occlusion concept: canine-guided occlusion versus bilateral balanced occlusion in a cross-over trial.

Purpose: The present cross-over study evaluated the masticatory function and maximum occlusal force of edentulous patients with complete dentures with bilateral balanced occlusion (BBO) and canine guidance (CG), with normal (NR) and resorbed mandibular ridges (RR).

Methods: Participants received new complete dentures and both occlusal concepts (BBO and CG) were applied for a period of 30 days each. The masticatory performance was evaluated with the sieving method; masticatory ability with a visual analog scale (VAS) and maximum occlusal force was assessed by means of a gnatodynamometer.

Retention Force and Wear Characteristics of three Attachment Systems after Dislodging Cycles.

Several attachment systems for mandibular implant-supported overdentures are currently available and studies are required to understand their mechanical properties. The objective of this study was to evaluate the retention force and wear characteristics of three attachment systems in a simulation of the cyclic dislodging of implant-supported overdentures. Thirty samples were fabricated and divided into 3 groups: 1-O-ring; 2-Mini Ball; and 3-Equator.

One-year prospective clinical study comparing patient satisfaction and masticatory performance of mandibular overdentures supported by one versus two implants.

Objective: There is a lack of clinical evidence on mandibular overdentures (MOD) supported by a single implant. To compare patient satisfaction and masticatory performance in MOD supported by one versus two implants in a two-group parallel randomized clinical trial.

Material And Methods: Twenty-one patients wearing new maxillary and mandibular complete dentures (CDs) were randomly divided to receive one (GI, n = 11) or two (GII, n = 10) implants in the mandibular arch.

Influence of the use of complete denture adhesives on microbial adhesion and biofilm formation by single- and mixed-species.

Objectives: To verify whether the Ultra Corega Cream and Corega Strip Denture Adhesive adhesives interfere in the microbial adhesion and biofilm formation by Candida albicans and Lactobacillus casei in single- and mixed-species settings, and observe whether synergistic or antagonistic relationships between these species occur.

Methods: Specimens made from heat-polymerized acrylic resin (Lucitone 550) were fabricated (n = 144) with a circular shape and standardized roughness (3.0 μm ±0.

A Randomized Clinical Trial of Oral Health-Related Quality of Life, Peri-Implant and Kinesiograph Parameters in Wearers of One-or Two-Implant Mandibular Overdentures.

Purpose: The present randomized clinical trial compared the oral health-related quality of life (OHRQoL), peri-implant parameters, mandible movements, and maxillary complete denture movement during chewing between wearers of single- (1-IOD) and wearers of two-implant overdentures (2-IODs) for a period of 12 months.

Materials And Methods: Twenty-one complete denture wearers were randomly allocated into two parallel groups: 1-IOD (n = 11) or 2-IODs (n = 10). The validated Brazilian version of the OHIP-EDENT was used to evaluate the OHRQoL.

Proinflammatory cytokine production from NOK-SI keratinocytes after exposure to denture adhesives.

Statement Of Problem: Although the cytotoxicity of denture adhesives has been widely assessed, data on the release of proinflammatory cytokines from oral epithelial cells are still scarce.

Purpose: The purpose of this in vitro study was to evaluate the proinflammatory cytokines interleukin (IL) 1β, IL-6, and tumor necrosis factor α (TNF-α) released from human oral keratinocytes after exposure to denture adhesives.

Material And Methods: Eluates of the Ultra Corega cream, Corega powder Fixador Ultra, and Corega strip denture adhesives were created at 1% wt/vol after 24 hours of exposure in a Dulbecco modified Eagle medium culture.