Publications by authors named "Pernille V S Olsen"
Article Synopsis
- Viruses are linked to over 15% of human cancer cases, but most studies have mainly looked at cancer transcriptome data rather than the viruses themselves.
- This research analyzed 197 cancer samples using high-throughput sequencing enriched for various viral groups, resulting in 710 datasets with a massive 57 billion sequencing reads.
- The study found a variety of viruses, particularly papillomaviruses and herpesviruses, in over half the samples but did not establish a specific connection between any viruses and particular cancer types.
Virus discovery from high throughput sequencing data often follows a bottom-up approach where taxonomic annotation takes place prior to association to disease. Albeit effective in some cases, the approach fails to detect novel pathogens and remote variants not present in reference databases. We have developed a species independent pipeline that utilises sequence clustering for the identification of nucleotide sequences that co-occur across multiple sequencing data instances.
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