Has the time come to stop routine N-acetylcysteine treatment in young children in Denmark? A review of 300 suspected paracetamol overdoses in children aged 0-6 years.

Aim: To evaluate the prevalence of potentially hepatoxic paracetamol ingestion and associated N-acetylcysteine treatment in young children suspected of paracetamol poisoning.

Methods: A retrospective cohort study of children aged 0-6 years suspected of paracetamol poisoning with a related plasma-paracetamol measurement in the Capital Region of Denmark in the period 2010-2017. Data from the clinical laboratory system were linked to data from electronic patient records via the unique identification number given to all Danish residents.

Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups.

Objectives: Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within the major histocompatibility complex (MHC). Since autoantibody presence defines specific clinical subgroups of IIM, we aimed to correlate serotype and genotype, to identify novel risk variants in the MHC region that co-occur with IIM autoantibodies.

Pulmonary function and autoantibodies in a long-term follow-up of juvenile dermatomyositis patients.

Objectives: Pulmonary disease is a rare complication in JDM, described in only a few studies. This long-term follow-up study aimed to (i) describe pulmonary involvement in a national cohort of JDM patients estimated by conventional spirometry, (ii) compare pulmonary impairment with overall JDM outcome, and (iii) identify possible associations between pulmonary impairment and myositis-specific autoantibodies (MSAs).

Methods: Fifty-one JDM patients performed conventional spirometry in a cross-sectional follow-up study.

Aerobic fitness after JDM--a long-term follow-up study.

Objectives: It has previously been shown that patients with active JDM have decreased aerobic fitness; however, it is not known whether these patients regain their physical fitness after recovery. The objective of this study was to investigate the long-term outcome of aerobic fitness in patients with JDM. We hypothesized that fitness (VO(2max)) is reduced compared with healthy controls in the years after active JDM.

[Congenital sternal cleft].

We describe two children with congenital sternal cleft. One child had a complete sternal cleft that was not operated upon, and at the age of 11 years the boy was still free of any symptoms. The other child had a superior partial sternal cleft that needed operative closure in the neonatal period.