The effect of single bout and prolonged aerobic exercise on tumor hypoxia in mice.

The objectives of this study were to investigate ) the effect of acute aerobic exercise on tumor hypoxia and blood perfusion, ) the impact of exercise intensity, ) the duration of the effect, and ) the effect of prolonged training on tumor hypoxia and tumor growth. Female CDF1 mice were inoculated with the C3H mammary carcinoma either in the mammary fat pad or subcutaneously in the back. For experiments on the effect of different intensities in a single exercise bout, mice were randomized to 30-min treadmill running at low-, moderate-, or high-intensity speeds or no exercise.

Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running.

Exercise has long been known to be beneficial to human health. Studies aimed at understanding the effects of exercise specifically focus on predetermined exercise intensities defined by measuring the aerobic capacity of each individual. Many disease models involving animal training often establish aerobic capacity by using the maximal lactate steady state (MLSS), a widely used method in humans that has frequently been used in rodent studies.