Concentrations of medetomidine enantiomers and vatinoxan, an α-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.

Objective: To quantify the peripheral selectivity of vatinoxan (L-659,066, MK-467) in dogs by comparing the concentrations of vatinoxan, dexmedetomidine and levomedetomidine in plasma and central nervous system (CNS) tissue after intravenous (IV) coadministration of vatinoxan and medetomidine.

Study Design: Experimental, observational study.

Animals: A group of six healthy, purpose-bred Beagle dogs (four females and two males) aged 6.