This review describes the current evidence regarding the putative indications of letrozole (LTZ) in fertility treatment. Prior to intrauterine insemination, LTZ is recommended in women with normogonadotrophic oligo-anovulation. In ovulatory women, LTZ is equal to clomiphene and may be used instead of exogenous gonadotrophin.
View Article and Find Full Text PDFIntroduction: Medication-related hospital admissions (MRAs) are common among older people. Persons with cognitive impairment are especially vulnerable to adverse drug effects. At the same time, increased home health care and social support could theoretically prevent medication-related problems.
View Article and Find Full Text PDFBackground: Evidence from preclinical studies suggests that probiotics affect brain function the microbiome-gut-brain axis, but evidence in humans remains limited.
Objective: The present proof-of-concept study investigated if a probiotic product containing a mixture of , and (in total 3 × 10 CFU/day) affected functional brain responses in healthy subjects during an emotional attention task.
Design: In this double-blinded, randomized, placebo-controlled crossover study (Clinicaltrials.
Proactive interference (PI) occurs when old information interferes with newly acquired information and has been suggested as a major cause of forgetting in working memory. In this study, we investigate cross-sectional (N = 267) and longitudinal (N = 148) associations between PI and white-matter integrity (WMI) using diffusion-weighted imaging in an adult life-span sample (25-80 years; M = 60.15; 138 female).
View Article and Find Full Text PDFIn the present study we have investigated whether Caveolin-1 expression in non-malignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients managed by watchful waiting. Caveolin-1 was measured in prostate tissues obtained through transurethral resection of the prostate from 395 patients diagnosed with prostate cancer. The majority of the patients (n = 298) were followed by watchful waiting after diagnosis.
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