Publications by authors named "Pernilla Andersson"

Article Synopsis
  • Changes in deoxyribonucleoside triphosphate (dNTP) pools are tied to higher mutation rates and genome instability in unicellular organisms, but their role in mammalian tumor development is not well understood.
  • A mouse model with a specific mutation in ribonucleotide reductase (RRM1-Y285A) showed decreased enzyme activity, leading to reduced dATP and dGTP levels, resulting in shorter lifespans and earlier tumor onset.
  • Analysis of the tumors indicated unique mutational signatures similar to those found in human cancers with related mutations in ribonucleotide reductase, suggesting that dNTP metabolism mutations may drive cancer development.
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This review describes the current evidence regarding the putative indications of letrozole (LTZ) in fertility treatment. Prior to intrauterine insemination, LTZ is recommended in women with normogonadotrophic oligo-anovulation. In ovulatory women, LTZ is equal to clomiphene and may be used instead of exogenous gonadotrophin.

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Introduction: Medication-related hospital admissions (MRAs) are common among older people. Persons with cognitive impairment are especially vulnerable to adverse drug effects. At the same time, increased home health care and social support could theoretically prevent medication-related problems.

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Background: Evidence from preclinical studies suggests that probiotics affect brain function the microbiome-gut-brain axis, but evidence in humans remains limited.

Objective: The present proof-of-concept study investigated if a probiotic product containing a mixture of , and (in total 3 × 10 CFU/day) affected functional brain responses in healthy subjects during an emotional attention task.

Design: In this double-blinded, randomized, placebo-controlled crossover study (Clinicaltrials.

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Proactive interference (PI) occurs when old information interferes with newly acquired information and has been suggested as a major cause of forgetting in working memory. In this study, we investigate cross-sectional (N = 267) and longitudinal (N = 148) associations between PI and white-matter integrity (WMI) using diffusion-weighted imaging in an adult life-span sample (25-80 years; M = 60.15; 138 female).

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In the present study we have investigated whether Caveolin-1 expression in non-malignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients managed by watchful waiting. Caveolin-1 was measured in prostate tissues obtained through transurethral resection of the prostate from 395 patients diagnosed with prostate cancer. The majority of the patients (n = 298) were followed by watchful waiting after diagnosis.

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