Publications by authors named "Pernicka J"

Article Synopsis
  • Patterns of failure and salvage treatment options for anal squamous cell carcinoma (ASCC) post-definitive IMRT were investigated, revealing limited data on patient outcomes after recurrence.
  • A study of 375 ASCC patients showed significant locoregional failure (12%) and distant failure (13%) rates, with 73% progression-free survival and 80% overall survival at six years, emphasizing poorer outcomes for those with locoregional failure.
  • Salvage therapies improved survival chances significantly, with 30% of patients alive after ten years, contrasting sharply with those receiving only chemotherapy or supportive care.
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Article Synopsis
  • Extramural venous invasion (EMVI) seen on MRI is linked to poorer outcomes in patients with advanced rectal cancer; the study looks into its persistence after total neoadjuvant therapy (TNT) and its impact on survival.
  • A retrospective analysis of 175 patients evaluated EMVI status via MRI and surgical pathology, revealing that regression of EMVI on both post-TNT MRI and pathology significantly improves disease-free and overall survival rates.
  • While EMVI can regress on surgical pathology even if it appears persistent on MRI, the implications of post-TNT MRI findings for treatment decisions and prognosis are still uncertain.
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International challenges have become the de facto standard for comparative assessment of image analysis algorithms. Although segmentation is the most widely investigated medical image processing task, the various challenges have been organized to focus only on specific clinical tasks. We organized the Medical Segmentation Decathlon (MSD)-a biomedical image analysis challenge, in which algorithms compete in a multitude of both tasks and modalities to investigate the hypothesis that a method capable of performing well on multiple tasks will generalize well to a previously unseen task and potentially outperform a custom-designed solution.

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A T1 sequence on routine baseline staging rectal magnetic resonance imaging (MRI) is thought to help detect bone lesions. Our primary aim was to evaluate the incidence of bone lesions encountered on baseline staging rectal MRI, particularly the prevalence of bone metastases. This retrospective study included patients with rectal adenocarcinoma who underwent baseline rectal MRI at our institution between January 2010 and December 2017.

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Objective: To determine the associations of pancreatobiliary maljunction (PBM) in the West.

Background: PBM (anomalous union of common bile duct and pancreatic duct) is mostly regarded as an Asian-only disorder, with 200X risk of gallbladder cancer (GBc), attributed to reflux of pancreatic enzymes. Methods: Radiologic images of 840 patients in the US who underwent pancreatobiliary resections were reviewed for PBM and contrasted with 171 GBC cases from Japan.

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Background: Subcapsular hepatic steatosis is a rare atypical pattern of fatty deposition of the liver reported in patients with diabetic nephropathy receiving peritoneal dialysis with intraperitoneal insulin. To date, there has been only one pediatric and zero adult cases of subcapsular hepatic steatosis with no history of continuous ambulatory peritoneal dialysis. We report the first published case of subcapsular hepatic steatosis in an adult diabetic patient without any history of peritoneal dialysis or evidence of chronic renal disease.

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The prognosis of oncological therapy of some malignancies is favourable. Unfortunately the majority of young patients remain sterile. Sperm cryopreserved before treatment was successfully used in IVF-ICSI (in vitro fertilization-intracytoplasmic sperm injection) cycles.

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This report presents a brief resume of the underwater visibility problem and explains the circular polarization approach for improving contrast. Experimental apparatus was set up at the Morris Dam facility of the U.S.

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