A Study of Proton Pump Inhibitors and Other Risk Factors in Warfarin-Associated Gastrointestinal Bleeding.

Background Warfarin users are at increased risk for gastrointestinal bleeding (GIB). History of GIB, stroke, cardiovascular or chronic kidney disease, age greater than 65 years, and drug interaction with proton pump inhibitors (PPI) have previously been identified as risk factors for GIB in warfarin users. We hypothesized that concomitant use of warfarin and PPI would increase the incidence of GIB relative to warfarin use alone.

Non-CNS pathogenic origin of Parkinson's disease.

The gut with its variety of microbiota may serve as an etiological origin of diseases. Gut microbes may also play a role in the pathogenesis of diseases beyond their simple nutritional maintenance and support. For example, gut protein aggregation, possibly aided by microbes as well as nasal influences, might be linked to disease that may move to the brain through the vagus nerve.

Perception of difficulty and glucose control: Effects on academic performance in youth with type I diabetes.

Aim: To investigate whether perceptions of task difficulty on neuropsychological tests predicted academic achievement after controlling for glucose levels and depression.

Methods: Participants were type 1 diabetic adolescents, with a mean age = 12.5 years (23 females and 16 males), seen at a northwest suburban Chicago hospital.

A review of the etiology, associated comorbidities, and treatment of orthostatic hypotension.

The magnitude of increase in systolic blood pressure in response to the shift from supine to upright posture is considered to reflect the adequacy of orthostatic regulation. Orthostatic integrity is largely maintained by the interaction between the skeletal muscle pump, neurovascular compensation, neurohumoral effects, and cerebral blood flow regulation. Various physiological states and disease conditions may disrupt these mechanisms as seen in vasovagal syncope, dysautonomic orthostatic intolerance, and postural orthostatic tachycardia syndrome.

Subclinical orthostatic pulse pressure confirms mothers' ratings of ADHD in preschoolers.

Subclinical levels of orthostatic hypotension (OH) have been linked to a variety of emotional and behavioral outcomes across the life span. These connections are not surprising, given the multitude of correlated conditions, including autonomic control, cardiovascular functioning, baroreceptor activity, and dopamine and serotonin. The current study assessed blood pressure regulation in healthy preschool children ages 3-5 (n = 61).

A review of orthostatic blood pressure regulation and its association with mood and cognition.

Aims: This paper will review literature that examines the psychological and neuropsychological correlates of orthostatic blood pressure regulation.

Results: The pattern of change in systolic blood pressure in response to the shift from supine to upright posture reflects the adequacy of orthostatic regulation. Orthostatic integrity involves the skeletal muscle pump, neurovascular compensation, neurohumoral effects and cerebral flow regulation.

Gender differences in orthostatic hypotension.

Orthostatic hypotension is a decrease in systolic blood pressure of more than 20 mm Hg or a decrease in diastolic blood pressure of at least 10 mm Hg, within 3 minutes of changing from a supine to an upright position. The typical clinical presentation of orthostatic hypotension includes dizziness, syncope, blurry vision and loss of balance. Symptoms may be more frequent in women, but the complicating roles played by comorbid factors and the estrogen mechanisms are not well understood.

Cognition and hopelessness in association with subsyndromal orthostatic hypotension.

Background: The move from lying to standing is typically associated with a variety of physiological and neurohumoral changes, most especially a slight increase in systolic blood pressure (SBP). Decreased efficacy of the various mechanisms that control orthostatic blood pressure (BP) regulation may result in lightheadedness, dizziness, syncope, and cerebral hypoperfusion. The lack of effective orthostatic BP regulation is a symptom for various problems, including fatigue, depression, anxiety, and reduced attention.

The negative association of BMI with classroom effort in elementary school children.

This study was designed to evaluate the association between BMI and classroom effort in third to fifth grade, ages seven through 12. Teachers, completely blinded and unaware of the study at the time of their classroom evaluations, provided reports of academic performance and effort. Boys and girls (n = 45), which are members of an ethnically diverse community, participated.

Subsyndromal orthostatic blood pressure regulation correlates with motor skills in head start children.

The purpose of this study was to investigate the functional relationship between subsyndromal orthostatic blood pressure regulation and motor skills in 3-5 year old children. It is known that the efficiency of orthostatic blood pressure regulation is affected by a variety of processes, most especially neurohumoral as well as sympathetic nervous system function. Using the DIAL-3 to evaluate gross motor (jump, hop, skip), fine motor (building) and copying abilities, we found a significant curvilinear association between the difference in systolic blood pressure following an orthostatic challenge and the DIAL-3 composite motor skills score.

Etiology and risk factors for developing orthostatic hypotension.

Orthostatic hypotension (OH) is regarded as a decrease primarily in systolic blood pressure on changing position from supine to erect. Based on clinical criteria, it is characterized by a decrease in systolic pressure of 20 mmHg and diastolic pressure of 10 mmHg within 1 to 3 minutes of standing after being supine. It is most prevalent in, although not limited to, the elderly population and is characterized by a variety of problems, including diminished cognition and disturbed emotion along with gate problems, falls, and brain and cardiovascular difficulties.

Rate of peripheral glucose change during cognitive testing predicts performance in diabetes mellitus.

Background: The reason for cognitive deterioration in diabetes mellitus (DM) remains unknown. One suggestion is that despite elevated glucose levels, patients with DM generally have difficulty utilizing glucose during cognitive tasks. This assumption was tested in the present study.

Improving glycemic control: the role of leisure activities and intrinsic motivation in older type 2 diabetic men.

Greater frequency of involvement with sedentary leisure activities may be associated with better disease outcomes. In this study, the frequency of engagement in sedentary leisure activities served as a construct employed to reflect the possible association between motivation and adherence with diabetic regimen. Up to a point, the higher frequency of leisure behaviors correlated with improved glycemic control and triglyceride levels in older type 2 diabetic male veterans (N = 49).

Blood glucose levels before and after cognitive testing in diabetes mellitus.

The primary indices of diabetes mellitus (DM), including hemoglobin A1c (HbA1c) and fasting glucose, appear to be only moderately predictive of the cognitive impairments exhibited by patients with DM. There is evidence that in DM the ability to utilize glucose is compromised and the authors hypothesized that this difficulty might be relevant to the study of cognitive function in DM. Thus, the authors examined the relationship between cognitive performance and changes in peripheral glucose from the start to the conclusion of cognitive testing.

Parents matter: intergenerational influences of diabetes mellitus on glycemic control and morbidity in older type 2 diabetic males.

In a cross-sectional study, the effects of disease duration of type 2 diabetes mellitus (DM) were examined along with parent history of DM on disease-related outcome variables. Specifically, the moderating role of parent history of DM on outcome variables was examined. Participants were 53 male veterans with DM.

Light to moderate alcohol drinking is associated with higher cognitive function in males with type 2 diabetes.

This study examined cognitive function in males with type 2 diabetes who drank light to moderate levels of alcohol in comparison to abstainers. Patients who abstained from alcohol use (Abstainer; N = 99) were compared to patients who were current drinkers (Drinker; N = 20) with respect to demographic, clinical, and cognitive variables. There were no significant differences between the Drinker and Abstainer groups in demographic and general clinical variables (p values > .

Race moderates age-related cognitive decline in type 2 diabetes.

The age-related rate of cognitive decline in patients with diabetes mellitus has received relatively little attention. In this cross-sectional study, Caucasian (N = 145) and African American (N = 25) males with diabetes mellitus were recruited to examine age-related changes in cognitive performance. It is known that African Americans with diabetes mellitus are at increased risk for more frequent and more severe diabetes-related complications.

Orthostatic blood pressure regulation predicts classroom effort in children.

The increase in orthostatic systolic blood pressure associated with the shift in posture from lying to standing requires several compensatory mechanisms to ensure adequate cerebral perfusion. Decreased efficiency in the various mechanisms controlling orthostatic blood pressure regulation can result in dizziness, lightheadedness, and syncope. The degree of effectiveness of orthostatic systolic blood pressure regulation (OBPR) serves as a marker for a variety of problems including fatigue, depression, anxiety, reduced attention, impulsive behavior and reduced volition.

Brief report: disordered eating and psychosocial factors in adolescent females with type 1 diabetes mellitus.

Objective: To evaluate whether insulin pump therapy [continuous subcutaneous insulin infusion (CSII)] is associated with a lower frequency of disordered eating, better glycemic control, and improved quality of life and self-efficacy compared to multiple daily injections (MDI) in adolescent females with type 1 diabetes mellitus (T1DM).

Methods: This cross-sectional study included 22 adolescent females using CSII and 47 adolescent females using MDI who completed standardized questionnaires measuring disordered eating, quality of life, and self-efficacy. Most recent glycosylated hemoglobin (HbA1(c)) and measures of personal characteristics were drawn from medical records.

Survival after percutaneous endoscopic gastrostomy: the role of dementia.

Background: Percutaneous Endoscopic Gastrostomy (PEG) is a widely used technique for enteral feeding in nursing home patients. Several factors including malnutrition, hypoalbuminemia, older age, number of co-morbidities and cognitive impairment adversely affect survival.

Objective: This study evaluated the relative impact of age, serum albumin, number of co-morbid illnesses and dementia on survival in male nursing home patients who had undergone percutaneous endoscopic gastrostomy (PEG).

Effects of choice on performance in two cultures.

Research in Japan and the United States has demonstrated that learning and memory may be improved when individuals are permitted to choose materials to be learned. In Japanese studies, the effects appear to be limited to the specific materials actually chosen, whereas in the United States, choice enhances recall of chosen as well as other materials that are later assigned. In the United States, personal choice has been hypothesized to affect both the learner's relationship to the chosen materials as well as motivation; in Japan personal choice affects the relationship between the learner and the chosen materials.

Estrogen replacement therapy, subsyndromal depression, and orthostatic blood pressure regulation.

Although estrogen replacement therapy (ERT) alleviates depressed moods in postmenopausal women, it is not known whether ERT is equally effective in reducing affective and somatic depressive complaints. One of the authors' goals in this study was to examine possible differences between women receiving and not receiving ERT. The authors studied a group of postmenopausal women.

Personal control and disordered eating in female adolescents with type 1 diabetes.

Objective: The onset and subsequent management of diabetes can challenge one's sense of control. Sense of control can also be affected by the biological changes accompanying normal pubertal development. The negative impact on one's sense of control may be further exacerbated when both events (i.

Postprandial systolic blood pressure and subsyndromal depression.

Changes in systolic blood pressure following the consumption of a standard meal were measured. We hypothesized that larger postprandial drops in systolic blood pressure would be associated with elevated subsyndromal depressive symptomatology. Following an overnight fast, individuals consumed a liquid meal.