Publications by authors named "Perla Scalini"
Article Synopsis
- The study aimed to determine specific cut-off levels for basal LH and ultrasound parameters indicating HPG axis activation for diagnosing Central Precocious Puberty (CPP) in girls.
- It involved 248 girls suspected of precocious puberty, who were divided into three groups and underwent a GnRH stimulation test while their hormonal levels and ultrasound parameters were measured.
- The findings indicated that a basal LH level of ≥0.14 mIU/mL was the most predictive for diagnosing CPP, while uterine length and LH/FSH ratios also provided useful diagnostic information but with varying degrees of sensitivity and specificity.
Ewing sarcoma (EWS) is a paediatric aggressive malignant tumour of bones and soft tissues. Multidisciplinary chemotherapies, surgical resection, and radiation represent the only strategies counteracting the disease, however spreading and relapse of disease still remain a clinical issue. Circulating tumour cells (CTCs) are an important feature of EWS but the prognostic significance has not been, yet, clarified.
View Article and Find Full Text PDFGrowth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life.
View Article and Find Full Text PDFAim: The effect of a supernumerary X chromosome on bones has not been reported, and this study evaluated bone mineral status and metabolism in nonmosaic triple X syndrome.
Methods: This cross-sectional study comprised 19 girls, with a median age of 10.9 years, with nonmosaic triple X syndrome and a control group matched for age and body size.
Objective. Klinefelter syndrome (KS) has long-term consequences on bone health. However, studies regarding bone status and metabolism during childhood and adolescence are very rare.
View Article and Find Full Text PDFObjective: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS).
Patients: Thirty-one children (15 females, 16 males; mean age 9.6±2.
Objective: To evaluate the hypothalamus-hypophysis-gonad axis in a cohort of children and adolescents with nonmosaic triple X syndrome.
Design: Cross-sectional study with retrospective analysis.
Setting: University pediatric hospital.
The study objective was to report treatment with an interleukin (IL)-1 receptor antagonist, anakinra, in patients with multiorgan Behcet's disease (BD). Comparison of clinical manifestations, previous treatments, markers of inflammation, concomitant medications, treatment regimen modifications, relapses, and adverse events before and during anakinra administration among patients with BD were evaluated. Nine BD patients (mean age 34.
View Article and Find Full Text PDF