Publications by authors named "Perla Negro"
Article Synopsis
- Metformin, a medication known for its ability to inhibit cell growth, has demonstrated effectiveness against the larval stage of a parasite in experimental models of cystic echinococcosis (CE).
- Administered at a high dose of 250 mg/kg/day, metformin was found to significantly reduce the size of parasite cysts and disrupt their internal structure, while also decreasing their glucose availability, which limits the parasite's energy and growth potential.
- The study suggests that metformin could be a valuable treatment option for CE, prompting the need for further research to optimize its use in humans suffering from this chronic disease.
Cystic echinococcosis (CE) is a worldwide zoonosis caused by the Echinococcus granulosus larval stage. The currently available therapy for this disease is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, new treatment options are needed.
View Article and Find Full Text PDFThe aim of this work was to determine Echinococcus granulosus sensu lato species and genotypes in intermediate and definitive hosts and in human isolates from endemic regions of Argentina and Brazil including those where no molecular data is available by a combination of classical and alternative molecular tools. A total of 227 samples were isolated from humans, natural intermediate and definitive hosts. Amplification of cytochrome c oxidase subunit I gene fragment was performed and a combination of AluI digestion assay, High Resolution Melting analysis (HRM) assay and DNA sequencing was implemented for Echinococcus species/genotype determination.
View Article and Find Full Text PDFObjective: To systematically review publications on Echinococcus granulosus sensu lato species/genotypes reported in domestic intermediate and definitive hosts in South America and in human cases worldwide, taking into account those articles where DNA sequencing was performed; and to analyse the density of each type of livestock that can act as intermediate host, and features of medical importance such as cyst organ location.
Methods: Literature search in numerous databases. We included only articles where samples were genotyped by sequencing since to date it is the most accurate method to unambiguously identify all E.