Near-normal glucose tolerance tests in diabetic dogs were obtained during basal rate insulin infusions in restrained animals by use of extracorporeal infusion pumps and in conscious, unrestrained animals by means of implanted infusion pumps. Even better regulation of blood glucose in diabetic animals was obtained by the addition of predetermined pulses of insulin at higher flow rates than the basal flow rate, accomplished by use of a transcutaneously activated valve mechanism attached to the implanted infusion pump. We conclude that near-normal blood glucose concentrations can be maintained throughout the day in the dog by these means and that similar approaches, using implantable infusion pumps, in man may lead to better long-term control of diabetes than is currently available.
View Article and Find Full Text PDFTrans Am Soc Artif Intern Organs
January 1979
Occlusion of the ipsilateral renal artery prior to nephrectomy is facilitated by substituting contrast material for air in the balloon of the Swan-Ganz catheter. The higher specific gravity of the contrast medium causes the balloon to settle in the bloodstream instead of floating in it, permitting it to be carried rapidly into the renal artery.
View Article and Find Full Text PDFKnowledge of the normal liver size is essential for making the scintigraphic estimate of hepatomegaly. A nomogram for sonographic liver size versus height of the patient was developed for the normal pediatric patient. Liver size was measured as the longitudinal liver length in the plane midway between the xiphoid and the right lateral liver margin.
View Article and Find Full Text PDFA patient with Fanconi's anemia who developed a hepatoma after 50 months of therapy with anabolic steroids is reported. The lesion presented as a cold focal defect on a Tc99m sulfur colloid scintigram, but was avascular on dynamic scintigraphy. Both the unusual avascularity of the hepatoma, and its association with anabolic steriod therapy are discussed.
View Article and Find Full Text PDFA modified Beckmann cryoscopic apparatus is described which is suitable for the measurement of the molecular weights, in solution, of air-sensitive compounds. Results are presented for some aryl compounds of aluminium and of gallium. The accuracy achieved is generally between 1 and 2%.
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