Publications by authors named "Perkin P K Kwan"
The PTTG1-binding factor (PBF) is a transforming gene capable of eliciting tumor formation in xenograft models. However, the precise role of PBF in tumorigenesis and its prognostic value as a cancer biomarker remain largely uncharacterised, particularly in malignancies outside the thyroid. Here, we provide the first evidence that PBF represents a promising prognostic marker in colorectal cancer.
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- The human pituitary tumor transforming gene (hPTTG) is a proto-oncogene linked to tumor growth, regulated by cyclin-dependent kinase 2 (CDC2) and specificity protein 1 (SP1).
- *In thyroid cells, growth factors like EGF, TGFα, and IGF-1 boost hPTTG expression and phosphorylation, activating key signaling pathways independently of CDC2 and SP1.
- *Transgenic and knockout mouse models showed that hPTTG influences thyroid cell growth and signaling, suggesting its significant role in promoting cell transformation and growth through autocrine mechanisms.