binds to CELF2 in newly diagnosed multiple myeloma promoting short progression-free survival to standard therapy.

Multiple Myeloma (MM) is a highly prevalent and incurable form of cancer that arises from malignant plasma cells, with over 35,000 new cases diagnosed annually in the United States. While there are a growing number of approved therapies, MM remains incurable and nearly all patients will relapse and exhaust all available treatment options. Mechanisms for disease progression are unclear and in particular, little is known regarding the role of long non-coding RNAs (lncRNA) in mediating disease progression and response to treatment.

Cryptic diversity and species boundaries within the Paragalago zanzibaricus species complex.

The recently described genus Paragalago is a complex of several nocturnal and morphologically cryptic species distributed in the forests of eastern Africa. Species diversity within this genus has been mainly described using species-specific differences in their loud calls. However, molecular data are still lacking for this group and species boundaries remain unclear.

Species Boundaries within Morphologically Cryptic Galagos: Evidence from Acoustic and Genetic Data.

Describing primate biodiversity is one of the main goals in primatology. Species are the fundamental unit of study in phylogeny, behaviour, ecology and conservation. Identifying species boundaries is particularly challenging for nocturnal taxa where only subtle morphological variation is present.

Sleep patterns, daytime predation, and the evolution of diurnal sleep site selection in lorisiforms.

Objectives: Synthesize information on sleep patterns, sleep site use, and daytime predation at sleep sites in lorisiforms of Asia and Africa (10 genera, 36 species), and infer patterns of evolution of sleep site selection.

Materials And Methods: We conducted fieldwork in 12 African and six Asian countries, collecting data on sleep sites, timing of sleep and predation during daytime. We obtained additional information from literature and through correspondence.

A giant among dwarfs: a new species of galago (Primates: Galagidae) from Angola.

Objectives: Based on vocalization recordings of an unknown galago species, our main objectives were to compare morphology and call structure with known closely-related taxa and describe a new species of galago.

Materials And Methods: We conducted field surveys in three forest habitats along the escarpment region in western Angola (Kumbira Forest, Bimbe Area, and Northern Scarp Forest), and examined galago specimens from museums worldwide. We digitized and analyzed calls using Avisoft SASLab Pro software.

Remarkable ancient divergences amongst neglected lorisiform primates.

Lorisiform primates (Primates: Strepsirrhini: Lorisiformes) represent almost 10% of the living primate species and are widely distributed in sub-Saharan Africa and South/South-East Asia; however, their taxonomy, evolutionary history, and biogeography are still poorly understood. In this study we report the largest molecular phylogeny in terms of the number of represented taxa. We sequenced the complete mitochondrial cytochrome gene for 86 lorisiform specimens, including ∼80% of all the species currently recognized.

The primates of the Udzungwa Mountains: diversity, ecology and conservation.

The Udzungwa Mountains are one of the most important areas in Africa for primate diversity and conservation, with two endemic monkeys (Udzungwa red colobus Procolobus gordonorum and Sanje mangabey Cercocebus [galeritus] sanjei), and the near-endemic kipunji monkey Rungwecebus kipunji, a new genus and species discovered in 2004 and found in Udzungwa and Southern Highlands. With six species of galagos, or bushbabies, the area is also of exceptional importance for nocturnal primates. The form of Mountain galago Galagoides orinus occurring in the Udzungwa Mountains appears to be distinct on the base of vocalizations, and further work will be required to assess its taxonomic status.

Comparative penile morphology of East African galagos of the genus Galagoides (family Galagidae): implications for taxonomy.

Recent studies on the comparative penile morphology of galagos have revealed complex patterns that vary among both genera and species, and help with species identification. So far the penile morphologies of 14 galago species have been described and an identification key has been proposed. The present study extends and revises previous work.

Species-typical patterns of infant contact, sleeping site use and social cohesion among nocturnal primates in Africa.

This paper provides a checklist and summary of what is currently known of the variation in infant contact, sleeping site preference and aspects of social cohesion in the nocturnal primates of Africa. Genera and species are compared, based on previously unpublished field observations and a review of the literature. There is a clear pattern of similarity between the species within each genus and distinct differences between genera.

Effects of adding potassium iodate to milk before UHT treatment. I. Reduction in the amount of deposit on the heated surfaces.

Additions of potassium iodate to milk at 0.05 and 0.1 mM (10 and 20 ppm) before UHT treatment markedly reduced the rate at which pressure built up during processing.

Comparison of milks processed by the direct and indirect methods of ultra-high-temperature sterilization: V. Denaturation of the whey proteins.

SummaryThe distribution of protein nitrogen was determined in milk treated by an experimental ultra-high-temperature (UHT) plant, operating alternatively as an indirect or as a direct heating plant.The extent of denaturation of β-lactoglobulin can be used to assess the relative severity of UHT heat treatments; this criterion was used to compare the indirect and direct arrangements of the plant with each other and with other published results.The time-temperature profiles of the plant were used to calculate the expected extent of denaturation of β-lactoglobulin during treatment of the milk.