[Healthy aging in Geneva : the innovative approach of the VieSA project].

With Switzerland's population ageing, promoting healthy ageing remains a public health issue. This represents a challenge for the healthcare system, which is still mainly focused on curative or palliative care. It has been clearly established that it is possible to maintain the functional capacity of older people by taking early action on health-related behaviors.

Intrinsic Capacities, Functional Ability, Physiological Systems, and Caregiver Support: A Targeted Synthesis of Effective Interventions and International Recommendations for Older Adults.

The ageing population calls for interventions that can assist older people to age healthily. This study aimed to provide a targeted synthesis of high-level research and current evidence-based recommendations on effective interventions for maintaining or preventing the decline in intrinsic capacity, functional ability, and physiological systems, or for caregiver support. Nestled within the healthy ageing framework by the World Health Organization, available evidence was selected in a targeted manner, with the purpose of providing a synthesis that would allow the application of this knowledge in real life.

Delirium in Older Patients With COVID-19: Prevalence, Risk Factors, and Clinical Relevance.

Background: Delirium prevalence increases with age and is associated with poor outcomes. We aimed to investigate the prevalence and risk factors for delirium in older patients hospitalized with COVID-19, as well as its association with length of stay and mortality.

Method: This was a retrospective study of patients aged 65 years and older hospitalized with COVID-19.

[Issues and challenges related to COVID-19 in acute geriatric care: lessons learned from the Geneva experience].

The older patients have been the most affected by the SARS-CoV-2 pandemic. In addition, this infection has been responsible for high mortality rate in this population. In this article we wanted to describe the clinical findings we encountered in older people with COVID-19 and share some of the issues and challenges we faced during the COVID-19 pandemic.

Predictors of In-Hospital Mortality in Older Patients With COVID-19: The COVIDAge Study.

Objective: To determine predictors of in-hospital mortality related to COVID-19 in older patients.

Design: Retrospective cohort study.

Setting And Participants: Patients aged 65 years and older hospitalized for a diagnosis of COVID-19.

[2016 Update in general internal medicine : Good intentions, possible bad outcomes].

Ideally, our clinical practices and decisions should be based on evidence derived from randomized clinical trials. Yet, we often have to determine the potential side effects (including interactions) of drugs that we prescribed using other level of evidence; clinical trials being obviously not appropriate for such situations. Results from observational studies published in 2016 should be of interest to primary care physicians.

[Practical approach of insomnia in the elderly].

Elderly people often suffer from insomnia which is responsible for high comorbidity and lower quality of life in this population. Somatic and psychiatric pathologies must be screened as primary sleep disorders. Chronic sleep disorders and benzodiazepine abuse might be avoided by an early treatment of causal factors.

[New professional field in France: Analysis of the training needs of case managers].

Case management is a relatively new career field in France. It was first introduced on an experimental basis in 2007-2008, and was then developedfollowing the National Alzheimer Plan and finally enshrined in legislation in 2012. This careerfield is based on a set of tasks widely described internationally: identifying the right level of intervention, standardized multidimensional assessment, planning all aid (care and social services), implementation of the plan, monitoring and reassessment and periodic reassessment of all needs in a continuous and long-term process.

[Bullous pemphigoid: a cutaneous disorder to be known in aging persons].

Bullous pemphigoid is a rare autoimmune muco-cutaneous disorder involving particularly aged adults. Its incidence may be underestimated. Recent studies show the various clinical presentations that may delay diagnosis up to several years in absence of typical bullous presentation.

Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.

Melatonin is a powerful antioxidant and a synchronizer of many physiological processes. Alteration of the melatonin pathway has been reported in circadian disorders, diabetes and autism spectrum disorders (ASD). However, very little is known about the genetic variability of melatonin receptors in humans.

[Increase of serum procalcitonin levels during a neuroleptic malignant syndrome].

When fever occurs in a patient treated with a neuroleptic, the diagnosis of a neuroleptic malignant syndrome is difficult to differentiate to that of an infectious event. Among inflammation biomarkers of inflammation, serum procalcitonin levels increase both quickly and specifically during a bacterial infection. We report the first case of a neuroleptic malignant syndrome associated with a significant increase of serum procalcitonin levels, without concomitant septic syndrome.

[Ekbom syndrome or delusional parasitosis].

Ekbom syndrome or delusional parasitosis is mainly described in presenile women who are unmarried or living alone. The presenting dermatological symptom is persistent pruritus, and the patients take medical advice in several practitioners one after another. The typical symptom is the behaviour of bringing sample of the allegered parasites inside small containers, defined as the "matchbox sign".

[Management of blood eosinophilia in an outpatient clinic for tropical diseases].

Objective: We assessed the frequency of parasitic diseases and the efficacy of presumptive treatment when no cause was found.

Materials And Methods: This prospective study took place in the Tropical Disease department of Bicêtre Hospital over a two-year period and included patients with eosinophil counts exceeding 500/mm(3).

Results: The study included 117 patients with blood eosinophilia.