Publications by authors named "Periklis Marnas"
Effects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells.
Am J Physiol Lung Cell Mol Physiol
January 2025
Article Synopsis
- The study investigates how benign mesothelial cells respond to different types of pleural effusion fluids (PF) and focuses on the role of the BBSome in this process.
- Benign human mesothelial cells were exposed to PF from various conditions (mesothelioma, breast cancer, hemothorax, congestive heart failure) and changes in gene expression were measured using PCR to assess cell response.
- Results show that BBSome gene expression changes more significantly in 2D cultures compared to 3D, and that inducing disturbances in the Primary Cilium affects cell migration in both culture formats when exposed to PF.
Drosophila melanogaster is a widely used animal model in human diseases and to date it has not been applied to the study of the impact of tobacco use on human sexual function. Hence, this report examines the effects of different concentrations of cigarette smoke extract (CSE) exposure on the size and sexual behavior of D. melanogaster.
View Article and Find Full Text PDFIntroduction: Primary cilium (PC) is a single non-motile antenna-like organelle composed of a microtubule core axon originating from the mother centriole of the centrosome. The PC is universal in all mammalian cells and protrudes to the extracellular environment receiving mechanochemical cues that it transmits in the cell.
Aim: To investigate the role of PC in mesothelial malignancy in the context of two-dimensional (2D) and three-dimensional (3D) phenotypes.