Publications by authors named "Perez-Stable E"

Objectives: The singular focus on self-identified race and ethnicity in health disparities research may not fully convey the individual and structural components of experiencing race in society, or in a racialized context such as prison. Processes of racialization create boundaries between incarcerated individuals and regulate their daily interactions and access to resources, with possible effects on well-being. However, the relationship between perceived race and health has not been examined within the imprisoned population.

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Background: Tobacco biomarkers reflect smoking intensity and are used to assess cessation status. No study has evaluated variation by Latino heritage.

Methods: Data from the 2007 to 2014 National Health and Nutrition Examination Survey were used to evaluate geometric mean concentrations of serum cotinine and urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), stratified by smoking status and race and ethnicity, and ROC curves estimated values to distinguish smokers from nonsmokers by race and ethnicity and Latino heritage.

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The human brain undergoes rapid development during the first years of life. Beginning in utero, a wide array of biological, social, and environmental factors can have lasting impacts on brain structure and function. To understand how prenatal and early life experiences alter neurodevelopmental trajectories and shape health outcomes, several NIH Institutes, Centers, and Offices collaborated to support and launch the HEALthy Brain and Child Development (HBCD) Study.

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Importance: Although scientific and technological discoveries have improved the health of the US population overall, racial and ethnic minority (American Indian and Alaska Native, Asian, Black or African American, Hispanic or Latino, or Native Hawaiian and Pacific Islander persons) and socioeconomically disadvantaged populations continue to experience a disproportionate burden of disease and other adverse health conditions. To better understand and address the drivers of health disparities and inform the development of effective interventions, integrative mechanistic studies examining the dynamic interplay of multiple factors across the life course and even between generations are needed. The emerging field of social epigenomics, which seeks to link social stressors and protective factors to health status through the examination of epigenomic modifications of various biological pathways, is one promising area of research contributing to this need.

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Article Synopsis
  • Heart failure (HF) risk is significantly higher in rural areas compared to urban regions in the UK, even with universal healthcare, suggesting that factors beyond access to care are at play.
  • The study analyzed data from over 417,000 participants and found that even in smaller or rural settings, the risk of HF was notably elevated, with biological aging linked to a 6.6% mediation of this risk.
  • This research highlights the importance of considering environmental, social, and dietary influences on health, emphasizing new targets for public health interventions aimed at reducing HF disparities.
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Background: Heart failure (HF) and kidney disease frequently co-occur, increasing mortality risk. The cardiorenal syndrome results from damage to either the heart or kidney impacting the other organ. The epidemiology of cardiorenal syndrome among the general population is incompletely characterized and despite shared risk factors with HF, differences in mortality risk across key demographics have not been well described.

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  • - Health equity means everyone has equal chances to achieve their best health, but human genomics research has not reflected the diversity of the population, leading to health disparities.
  • - The National Human Genome Research Institute (NHGRI) acknowledges these inequities and has gathered experts to provide recommendations and review the current state of health equity in genomics.
  • - This report outlines the gaps and opportunities in bridging human genomics with health equity, emphasizing the need for more diverse participation in genomics research to improve health outcomes for all.
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  • - The older adult population in the U.S. is increasing and becoming more diverse, yet there’s a lack of data on the aging process in underserved groups.
  • - Equitable participation in aging research and workforce representation is crucial for improving health outcomes for everyone, though significant disparities still exist.
  • - This discussion highlights aging health disparities, introduces frameworks to guide research, and examines strategies and current efforts to enhance diversity in healthcare and research fields.
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Health disparities are driven by unequal conditions in the environments in which people are born, live, learn, work, play, worship, and age, commonly termed the Social Determinants of Health (SDoH). The availability of recommended measurement protocols for SDoH will enable investigators to consistently collect data for SDoH constructs. The PhenX (consensus measures for Phenotypes and eXposures) Toolkit is a web-based catalog of recommended measurement protocols for use in research studies with human participants.

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Studies have shown that financial hardship can impact weight change; however, it is unclear what the economic impact of the COVID-19 pandemic has had on weight change in U.S. adults, or whether racial-ethnic groups were impacted differentially.

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  • Chronic kidney disease significantly impacts global health, particularly among individuals of African ancestry and those in the Americas, who are often excluded from genetic studies.
  • A comprehensive meta-analysis involving over 145,000 individuals from these groups led to the discovery of 41 significant genetic loci associated with kidney function, two of which hadn't been previously identified across any ancestry group.
  • The study emphasizes the importance of diverse populations in genetic research for better understanding kidney disease and suggests that multi-ancestry polygenic scores can improve predictive capabilities and clinical applications.
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Purpose: Examine trends in noncigarette tobacco use among smoking susceptible and nonsusceptible adolescents from 2009-2021.

Methods: Data came from cross-sectional samples of the National Youth Tobacco Survey (N = 183,198). Using Pierce's smoking susceptibility scale, participants were classified as either susceptible or nonsusceptible to cigarette smoking.

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  • The study aimed to investigate racial and ethnic disparities in the rates of inferior vena cava filter (IVCF) placements among Black and Latino patients with acute proximal lower extremity deep vein thrombosis (DVT) in the U.S. from 2016 to 2019.
  • It analyzed data from 134,499 DVT patients, finding that 14.1% received IVCFs, with the majority being White (67.3%), followed by Black (18.8%) and Latino (8.9%) patients.
  • The results showed a decrease in IVCF placements across all groups over time, with significant statistical disparities in placement rates, particularly noting that Black patients had higher rates (11-12/100,000
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Health equity is the aspirational assurance of optimal health for all. Synonymous with fair and just opportunities for physical and mental health, equity work reflects intentional efforts to remove access barriers and allocate high-quality, need-based resources. Health equity is not possible without meaningful reductions in disparities-and evaluating progress goes further to describe, assess, and continuously evaluate fairness and social justice within structures, community contexts, and healthcare.

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Aim: Although immigrants account for nearly half of Luxembourg's population, few studies have investigated differences in self-reported health by nationality in Luxembourg. Our study aimed to explore the association between nationality and self-reported health in Luxembourg.

Subject And Methods: Cross-sectional data from the 2015-2016 Panel Socio-Economique Liewen zu Lëtzebuerg (PSELL3) were used.

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Objective: In the United States (US), the health and financial consequences of COVID-19 have disproportionately impacted women and minoritized racial-ethnic groups. Yet, few US studies have investigated financial hardship during the COVID-19 pandemic and sleep health disparities. Our objective was to investigate associations between financial hardship and sleep disturbances during the COVID-19 pandemic by gender and race and ethnicity in the United States.

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