Publications by authors named "Perez-Gomez Alba"
Article Synopsis
- Scientists studied how a gene called TEAD4 affects early development in different mammals, like cows and rabbits.
- In mice, TEAD4 is really important for making certain cell types, but in the other animals, it didn't seem to be needed for the same process.
- Even though the gene wasn't necessary for some development steps, there were still some changes, like the number of cells in certain areas being lower in cows without TEAD4.
Article Synopsis
- After a blastocyst hatches, ungulate embryos go through a long phase called conceptus elongation, which is a crucial time when embryos can be lost.
- Scientists studied a specific gene called PPARG to see if it is necessary for the development of cattle embryos by creating embryos without this gene and comparing them to normal embryos.
- They found that even without PPARG, the embryos still developed normally through important stages, so PPARG is not essential for their growth.
Article Synopsis
- - The study investigates the relationship between mitochondrial DNA (mtDNA) content in cumulus cells (CCs) and embryo development potential in humans and cattle, aiming to determine if mtDNA can be a reliable predictor for oocyte development.
- - Results indicate that mtDNA content in CCs provides minimal predictive value for assessing oocyte developmental potential in both species, as it showed no significant differences among developmental outcomes.
- - Previous research suggested a link between mtDNA content in oocytes and developmental potential, but this study challenges the idea that mtDNA content in CCs can serve as a useful proxy for predicting embryo success during assisted reproductive technologies.
Embryonic losses constitute a major burden for reproductive efficiency of farm animals. Pregnancy losses in ungulate species, which include cattle, pigs, sheep and goats, majorly occur during the second week of gestation, when the embryo experiences a series of cell differentiation, proliferation, and migration processes encompassed under the term conceptus elongation. Conceptus elongation takes place following blastocyst hatching and involves a massive proliferation of the extraembryonic membranes trophoblast and hypoblast, and the formation of flat embryonic disc derived from the epiblast, which ultimately gastrulates generating the three germ layers.
View Article and Find Full Text PDF