Publications by authors named "Perez-Carrasco M"
Objectives: To determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.
Design: Prospective, observational, single-center study.
Setting: Intensive Care Unit (ICU), Vall d'Hebron University Hospital, Barcelona.
Introduction: This research endeavors to investigate the phenomenon of intraneural spread across distinct locations: subcircumneurium, extrafascicular intraneural, intrafascicular intraneural, and intraperineurium after deliberate intraneural injections across five mammalian species. The study also aims to propose determinants influencing this spread. Furthermore, the investigation strives to ascertain the optimal animal species and needle configuration for extrapolating intraneural injection outcomes to human contexts.
View Article and Find Full Text PDFThis study describes the incidence, evolution and prognosis of acute kidney injury (AKI) in critical COVID-19 during the first pandemic wave. We performed a prospective, observational, multicenter study of confirmed COVID-19 patients admitted to 19 intensive care units (ICUs) in Catalonia (Spain). Data regarding demographics, comorbidities, drug and medical treatment, physiological and laboratory results, AKI development, need for renal replacement therapy (RRT) and clinical outcomes were collected.
View Article and Find Full Text PDFObjectives: Patients with COVID-19-associated acute respiratory distress syndrome (ARDS) have a high risk for developing acute kidney injury (AKI) which is associated with an increased risk of death and persistent renal failure. Early prediction of AKI is crucial in order to implement preventive strategies. The purpose of this study was to investigate the predictive performance of tissue inhibitor of metalloproteinases 2 and insulin like growth factor binding protein 7 (TIMP-2) × (IGFBP7) in critically ill patients with COVID-19-associated ARDS.
View Article and Find Full Text PDFIntroduction: Stress inherent to health care, which is characterized by work overload and shortage of specialized staff, is associated with decreased quality of life and suboptimal patient care. Mindfulness-based programs have proved to be effective in reducing stress in healthcare providers. This study aims to assess the feasibility of an 8-week mindfulness program to reduce the burnout levels of the staff of a pain clinic in a tertiary public hospital.
View Article and Find Full Text PDFArticle Synopsis
- This case report discusses a patient with Hemophagocytic lymphohistiocytosis (HLH) triggered by NK-type non-Hodgkin lymphoma and Epstein-Barr virus, leading to severe organ dysfunction and shock.
- Comprehensive diagnostic tests, including a liver biopsy and bone marrow aspirate, confirmed the HLH diagnosis, and the patient met the HLH-2004 criteria.
- Treatment included corticosteroids and etoposide, along with cytokine hemoadsorption, which dramatically improved the patient's hemodynamics and reduced the need for vasopressive medications.
Article Synopsis
- Sepsis is a complex disease with varying symptoms and outcomes, increasing the risk of mortality, thus requiring structured treatment protocols.
- All patients should receive essential management strategies, including infection control, resuscitation, and support for multiple organs.
- Certain patient subgroups may benefit from tailored therapies targeting their specific conditions; while some methods are still being researched, others are already in clinical use to improve treatment outcomes.
Article Synopsis
- A dysregulated inflammatory response, called "cytokine storm," is critical in the severity of COVID-19, making it important to identify patients at risk for severe complications like organ dysfunction and death.
- The study evaluated the use of cytokine hemoadsorption as a rescue therapy in critically ill COVID-19 patients experiencing severe respiratory failure and an excess of cytokines.
- Among 343 ICU patients with SARS-CoV-2 infection, six underwent hemoadsorption, showing significant improvements in markers like D-dimer, C-reactive protein, ferritin, and interleukin-6, along with better oxygenation levels post-treatment. *
(1) Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a lot of time watching LED screens that emit high proportions of blue light.
View Article and Find Full Text PDFPurpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of the retina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-related layer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects.
Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants.
The mortality of septic shock remains high [Ann Intensive Care. 2017;7:19], so apart from usual therapy based on source control and antibiotics, some patients may need rescue therapies. Blood purification systems may play a role by facilitating the nonspecific removal of inflammatory mediators and microbiological toxins.
View Article and Find Full Text PDF(MIS-C) is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part of the supportive treatment for cytokine storm.
View Article and Find Full Text PDFAugmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimation formula and measured GFR. Observational, prospective, multicenter study.
View Article and Find Full Text PDFArticle Synopsis
- Non-technical skills like leadership and communication are crucial for effective teamwork during crises, and this study explored their impact on health professionals' emotional responses to the COVID-19 pandemic.
- A simulation-based training program was conducted before the outbreak, involving 48 doctors and 48 nurses, who later participated in a survey measuring stress, anxiety, and depression levels in May 2020.
- Results showed that while both groups experienced high levels of stress and anxiety, those trained in non-technical skills did not significantly differ from the control group, although contact with COVID-19 patients was a major factor in increased psychological distress.
Purpose/aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD).
Materials And Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area.
Purpose: To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes.
Methods: Measurements were made in 38 young and 38 older healthy individuals. Total, inner, and outer retinal layer (IRL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT) across three subfields, or rings, centered at the fovea: central foveal, pericentral, and peripheral.
Unlabelled: Purpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident early age-related macular degeneration (AMD) This study examines relationships between macular thickness measurements and photopic or mesopic VA in healthy eyes.
Materials And Methods: In 38 young and 39 older healthy individuals, total, inner, and outer retinal layer (IRL and ORL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT). Measurements were made across three subfields centered at the fovea: central foveal, pericentral, and peripheral.
Purpose: To compare disk halo size in response to a glare source in eyes with an aspheric apodized diffractive multifocal intraocular lens (IOL) or aspheric monofocal IOL.
Setting: Rementeria Ophthalmological Clinic, Madrid, Spain.
Design: Prospective randomized masked study.
Influenza infection in the intensive care unit: Four years after the 2009 pandemic.
Enferm Infecc Microbiol Clin
March 2016
Unlabelled: The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied.
Objective: To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of influenza-like illness (ILI), and to compare the features of pandemic vs.
Purpose: To determine the relationship between the size of a halo induced by a glare source and forward scatter or visual acuity (VA) in healthy eyes.
Method: Measurements were made in the right eyes of 51 healthy individuals of mean age 29.3 ± 7.
Objective: To study the use of optical coherence tomography (OCT), for measuring the macular thickness variations produced over time in elderly pseudophakic subjects implanted with a clear intraocular lens (IOL) in one eye, and a yellow IOL in the other eye.
Methods: Macular thickness measurements were obtained in the 36 eyes of 18 subjects over 65 years, with cataracts surgically removed from both eyes and implanted with different absorbance (clear and yellow) IOLs in 2 separate surgeries. Stratus-OCT was used to determine the macular thickness in 2 sessions with 5 years of difference.
Purpose: To determine the size of a halo in the visual field induced by bright light in healthy eyes of all ages using the Vision Monitor (MonCv3; Metrovision, Pérenchies, France) and to assess the repeatability of the method.
Methods: Measurements were made in the right eyes of 147 healthy subjects (mean age: 48.2 ± 16.
Purpose: Today the extent to which MP impacts visual function in early AMD remains unclear. This study examines the relationship between macular pigment optical density (MPOD) and high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD).
Methods: Measurements were made in 22 subjects with early AMD and 27 healthy control subjects.