Clinical management, expectations, and satisfaction of patients with moderate to severe allergic rhinoconjunctivitis treated with SQ-standardized grass-allergen tablet under routine clinical practice conditions in Spain.

Background: Sublingual immunotherapy has been proven as a well-tolerated and effective treatment for allergic rhinitis. Within this type of treatment, GRAZAX is the most documented product in terms of safety and efficacy. The objective of this study was to identify the patients' expectations and level of treatment satisfaction, as well as the clinical management of patients with moderate/severe allergic rhinoconjunctivitis treated with GRAZAX.

Occupational asthma caused by turbot allergy in 3 fish-farm workers.

We report 3 patients (26, 31, and 33 years) who worked at the same fish farm for several years. They experienced symptoms of rhinoconjunctivitis and bronchial asthma while classifying fish by size. Their asthma gradually worsened to the extent that it became persistent and required daily medication with inhaled corticosteroids and bronchodilators.

Acute ischaemic colitis due to hypotension and amoxicillin allergy.

A case of acute ischaemic colitis, confirmed by colonoscopy and colon biopsy, caused by IgE mediated allergy to amoxicillin is presented. The damage to the gut seemed to occur as a result of the hypotension suffered during the anaphylactic episode.

Nonpigmenting fixed drug eruption due to pseudoephedrine.

Background: The nonpigmenting fixed drug eruption is a distinctive drug reaction characterized by large, tender and symmetric erythematous plaques that disappear with no residual pigmentation.

Methods: A case of a non-pigmenting fixed drug eruption due to pseudoephedrine is reported.

Result: The reappearance of typical lesions at the same sites after oral challenge with 60 mg pseudoephedrine together with the absence of pigmentation confirm the diagnosis.

Unsuspected sources of soybean exposure.

Background: Hidden allergens in processed foods can provoke severe allergic reactions in sensitive individuals. The presence of soy proteins in typical Spanish sausage products (chorizo, salchichón, mortadella, and boiled ham), doughnut and soup stock cubes has not been reported previously.

Methods: The present article reports two examples of severe allergic reactions due to the ingestion of foods that unexpectedly contained soybean proteins.

Paracetamol (acetaminophen) hypersensitivity.

Background: Paracetamol (acetaminophen) intolerance can occur in less than 5% of aspirin-sensitive subjects as a result of inhibition of prostaglandin synthesis but hypersensitivity to paracetamol without aspirin sensitivity is rare.

Methods: We report a case of an acute life-threatening hypersensitivity reaction to paracetamol.

Results: An oral challenge with 125 mg of paracetamol was carried out and followed by generalized anaphylactic reaction.

Occupational asthma and rhinitis caused by ash (Fraxinus excelsior) wood dust.

An 18-year-old man who worked in a furniture factory reported rhinitis and asthma when he was exposed to ash wood dust. Monitoring of the patient's peak expiratory flow rate (PEFR) when off work and at work showed increased variations of PEFR at work. Basal PC20 methacholine was 1.

[Extrinsic allergic alveolitis caused by Penicillium frequentans. Review and presentation of a case].

We present a case of extrinsic allergic alveolitis due to Penicillium frequentans exposure (suberosis) at a cork factory. Diagnosis was based on clinical history, a restrictive spirometric pattern, evidence of reticular-nodular lung infiltrates on the X-ray, intradermal skin tests with dual reaction and precipitins-positive serum samples in the presence of the P. frequentans fungus.