Hepatic steatosis and severity-related factors in obese children.

Background And Aim: Obesity is an important health-care problem in developed countries. It is considered a multisystemic disease, but it may also affect the liver, thus provoking non-alcoholic fatty liver disease. This disease has been less extensively studied among children than among adults.

Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.

Human glutathione S-transferases (GSTs) are phase II metabolizing enzymes that play a key role in protecting against cancer by detoxifying numerous potentially cytotoxic/genotoxic compounds. The genes encoding the human GST isoenzymes GSTM(mu)1, GSTT(theta)1 and GSTP(pi)1 harbour polymorphisms, which have been considered important modifiers of the individual risk for environmentally induced cancers such as gastric cancer (GC). However, results are inconsistent among studies from different geographic areas and ethnic groups.

The changing face of hospitalisation due to gastrointestinal bleeding and perforation.

Background: Temporal changes in the incidence of cause-specific gastrointestinal (GI) complications may be one of the factors underlying changing medical practice patterns.

Aim: To report temporal changes in the incidence of five major causes of specific gastrointestinal (GI) complication events.

Methodology: Population-based study of patients hospitalised due to GI bleeding and perforation from 1996 to 2005 in Spain.

Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice.

Objectives: Changing patterns in medical practice may contribute to temporal changes in the incidence of upper and lower gastrointestinal (GI) complications. There are limited data on the incidence of lower GI complications in clinical practice and most studies that have been done have serious methodological limitations to inferring the actual burden of this problem. The aims of this study were to analyze time trends of hospitalizations resulting from GI complications originating both from the upper and lower GI tract in the general population, and to determine the risk factors, severity, and clinical impact of these GI events.

A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use.

Background: The worst outcome of gastrointestinal complications is death. Data regarding those associated with nonsteroidal antiinflammatory drug (NSAID) or aspirin use are scarce.

Aim: To determine mortality associated with hospital admission due to major gastrointestinal (GI) events and NSAID/aspirin use.

Clinical trends in ulcer diagnosis in a population with high prevalence of Helicobacter pylori infection.

Background: It is unknown whether the incidence of peptic ulcer changes in areas with a high prevalence of Helicobacter pylori infection.

Aim: To determine trends in peptic ulcer complications in a community with a high prevalence of H. pylori infection.

Helicobacter pylori infection is a protective factor for bleeding gastric ulcers but not for bleeding duodenal ulcers in NSAID users.

Background: The effect of Helicobacter pylori infection on NSAID-induced gastroduodenal damage is unclear.

Aim: To determine the role of H. pylori and NSAID use in complicated peptic ulcers.