[Effect of phytic acid and its derivatives on blood lipid peroxidation state in vitro].

We have studied specific features of lipid peroxidation in whole human blood under the action of aqueous solutions of xymedone (19.6 microM), phytic acid (117.9 microM) and its complex (237.

[System analysis of metabolic profile of blood in patients with thermal trauma].

Aim: To make multiparametric analysis of blood metabolic profile in early period of burn disease.

Materials And Methods: We tested blood samples of 15 healthy adults (control group) and 60 patients with thermal trauma (main group--II-4IIIA, B degree of burn, more then 15 bsp). Parameters of lipid metabolism, level of glucose, lactate, malonic dialdehyde and some enzymes in blood plasma and erythrocytes were estimated.

[Effect of dinitrosyl iron complexes on erythrocyte energy metabolism under thermal trauma conditions].

The effect of dinitrosyl iron complexes (DNIC) on the energy metabolism of erythrocytes under combined thermal trauma conditions has been studied on a group of 30 Wistar rats, which was divided into 3 groups: intact (n = 10), control (n = 10), and main (n = 10). Combined thermal trauma (skin burn + thermoinhalation damage) was modeled in animals of the control and main groups. Rats of control group received infusions of sodium chloride solution (n = 10) every day.

[Estimation of some molecular effects of gaseous nitrogen oxide on human blood in vitro].

The aim of this work is complex estimation of the nitric oxide action on whole blood of healthy people. We tested the reaction of whole human blood (n=14) to the processing of it with cold NO-containing plasma. We performed direct sparging of blood samples by gaseous flow with NO in a special plant.

[Specialties of singlet oxygen and ozone inhalations action on lipoperozydation and antioxidant system of rats blood and tissues].

The aim of this work was the analysis of singlet oxygen and the ozone effect on lipid peroxidation and antioxidant activity of rat organs and blood. Wistar rats were randomly divided into five groups: control group (without any manipulations; n = 10) and four main groups (n = 10 in each group) with inhalations by dry, moisture and oil-processed ozone-oxygen mixture (ozone concentration 60 micro g/l) or singlet oxygen, respectively. Activity of pro- and antioxidant systems was estimated in blood and tissues (lungs, heart, liver and kidney) by inducing biochemiluminescence.

[The platelet hemostatic system and prooxidant and antioxidant potentials in the dynamics of burn disease].

Platelet aggregation and prooxidant and antioxidant potentials were studied in patients with burn more than 20% total body surface area for 30 days after injury. There were progressive increases in platelet aggregation, lipid peroxidation, and antioxidant activity. The possible pathogenetic aspects of the findings are discussed.

[The effect of low-intensity laser radiation on blood metabolic indices in the postresuscitation period].

The effect of He-Ne laser radiation (632.8 nm; 0.3 mW/cm parallel to oxygenation on metabolism indices of blood, taken in early postresuscitation period after discontinuation of hemorrhagic shock was studied in vitro.

[The action of prednisolone on external respiratory function in hemorrhagic shock].

The dose-dependent effect of prednisolone (30 and 60 mg/kg) on the recovery of the external respiration function and the condition of the lung tissue following hypovolemic hypotension was studied in experiments on dogs. The efficacy of prednisolone (30 mg/kg) for correction of respiratory disorders was shown.

[Metabolic effect of gutimine on the myocardial tissue in blood loss].

A rate of hemorrhage accounted for 31 mg/kg in 80 adult dogs premedicated with promedol and atropine. After circular-hemic hypoxia caused by the hemorrhage, single intravenous administration of gutimine (35-40 mg/kg) transformed the carbohydrate metabolism in heart muscle: activated glycolysis and accelerated the rate of its products oxidation, maintained the free amino acids concentration at the level similar to that of intact animals, reduced the rate of creatine phosphate synthesis.

[Effect of sodium hydroxybutyrate on coronary hemodynamics and microcirculation during hypotension caused by blood loss].

Experiments of 34 dogs were made to study alterations in the cardio- and hemodynamics and microcirculation in the mesenterium during hypotension caused by hemorrhage after intravenous injection of sodium hydroxybutyrate and intravenous re-infusion of heparinized blood under a pressure of 80-120 mm Hg. It was established that single injection of sodium hydroxybutyrate in a dose of 180-200 mg/kg after a 60-minute decrease in the arterial pressure to 40 mm Hg increases pump function of the heart, venous blood returns to the heart, and improves microcirculation. This improvement manifests by the rise in the blood flow rate in the microvessels and in the number of functioning capillaries, and by diminution of red cell aggregation.

[Morphological changes in the lungs in the early recovery period after clinical death from acute blood loss depending on the method of its compensation].

Pathomorphological changes in the lungs in the period of clinical death due to acute blood loss and within 1 1/2--2 hours of resuscitation using intraarterial, intravenous, and intraosteal routes for blood loss substitution were studied in dogs. In the period of clinical death significant changes in the lung morphology were observed (capillary plethora, sludge, leukostasis, hemorrhages, fat embolism, irregular aeration of pneumonic tissue), in the early postresuscitation period the intensity of the changes varied in relation to the method of blood loss substitution. The above-mentioned methods are compared.