Publications by authors named "Perera Marlon"
Metastasis-directed therapy (MDT) in oligometastatic renal cell carcinoma (RCC) is typically based on conventional imaging. Prostate-specific membrane antigen (PSMA) PET/CT has shown superiority over conventional imaging. Our objective was to perform a proof-of-concept study to evaluate the efficacy of PSMA-guided MDT in oligometastatic RCC.
View Article and Find Full Text PDFThis review aims to provide an up-to-date overview of the utility of artificial intelligence (AI) in evaluating prostate-specific membrane antigen (PSMA) positron emission tomography (PET) scans for prostate cancer (PCa). A literature review was conducted on the Medline, Embase, Web of Science, and IEEE Xplore databases. The search focused on studies that utilizes AI to evaluate PSMA PET scans.
View Article and Find Full Text PDFBackground: stereotactic ablative body radiotherapy (SABR) is a disruptive radiation therapy technique which is increasingly used for the treatment of urologic cancers. The aim of this narrative review is to provide an overview on the current landscape of SABR in urologic cancers and highlight advancements on the horizon.
Methods: a narrative review of the contemporary role of SABR in urologic cancers is conducted.
Objective: To perform a systematic review and meta-analysis to assess the relationship between intraprostatic maximum standardised uptake value (SUV) of the dominant prostatic lesion as measured on preoperative prostate-specific membrane antigen (PSMA) positron emission tomography (PET) with radical prostatectomy International Society of Urological Pathology (ISUP) Grade Group, pathological tumour (pT) staging, and biochemical recurrence (BCR).
Methods: Prostate-specific membrane antigen PET may offer non-invasive assessment of histopathological and oncological outcomes before definitive treatment. SUV of the dominant lesion has been explored as a prognostic biomarker.
Objective: To investigate the relationship between the prostate-specific antigen (PSA) free-to-total ratio (FTR) and International Society of Urological Pathology Grade Group ≥2, clinically significant prostate cancer (csPCa) in men with a low PSA level (≤4 ng/mL). Patients and Methods Data were obtained from the Prostate Cancer Prevention Trial. Patients with a PSA level of ≤4 ng/mL and who received a biopsy within a year of this PSA measurement were included.
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- * Researchers found that higher FOLH1 expression was linked to increased tumor angiogenesis but did not show a consistent relationship with immune features, and it positively impacted progression-free survival (PFS) in patients treated with sunitinib.
- * The findings suggest that FOLH1 could be used as a noninvasive biomarker to guide treatment decisions for m-ccRCC patients, which may
: Biochemical recurrence (BCR) after radical prostatectomy (RP) is a significant predictor of distal metastases and mortality in prostate cancer (PCa) patients. This systematic review aims to evaluate the accuracy of artificial intelligence (AI) in predicting BCR post-RP. : Adhering to PRISMA guidelines, a comprehensive literature search was conducted across Medline, Embase, Web of Science, and IEEE Xplore.
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- Imaging advancements are crucial in renal cell carcinoma (RCC), with rising detection rates due to improved technology leading to incidental findings.
- A literature search up to May 2024 highlighted key imaging methods, including ultrasound, CT, MRI, and new technologies like CEUS and molecular imaging techniques.
- The future of RCC imaging points toward a more conservative treatment strategy, potentially reducing unnecessary surgeries or biopsies for benign lesions.
Introduction And Objectives: Full blood examinations, often referred to as FBE, are commonly ordered postoperatively, despite limited utility in many of its markers in the acute phase. It is estimated that in the 2022-2023 financial year, the Australian healthcare system billed over $13 million for full blood examinations (FBEs) to Medicare. This study aims to assess the cost of using FBE following surgery.
View Article and Find Full Text PDFBackground: During active surveillance (AS) for Grade Group (GG) 2 prostate cancer, pathologic progression to GG3 on surveillance biopsy is a trigger for intervention. However, this ratio of GP3:GP4, may be obscured by increases of relatively indolent disease. We aimed to explore changes in GP4 quantity during AS and propose alternative definitions for progression based on GP4 changes.
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- The study looked at how certain surgeries, like bowel diversion, help treat a serious condition called Fournier's gangrene, and the need for doctors from different specialties to work together.
- They found that these surgeries can help patients heal faster and need fewer additional procedures, even though having a stoma (a small opening in the belly) can sometimes make staying in the hospital longer.
- The research also showed that while larger wounds can benefit from special skin treatments, some past methods for testicle care are not recommended anymore because of possible risks and patient feelings.
The review examines the vital role of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in the diagnosis, staging, and treatment of prostate cancer (PCa). It focuses on the superior diagnostic abilities of PSMA PET/CT for identifying both nodal and distant PCa, and its potential as a prognostic indicator for biochemical recurrence and overall survival. Additionally, we focused on the variability of PSMA's expression and its impact on personalised treatment, particularly the use of [Lu] Lu-PSMA-617 radioligand therapy.
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