[Occult multicentric breast cancer].

The study included 92 patients with invasive ductal breast cancer (T2-4N0-2M0-1). In 38 cases, tumor growth was unicentric while histologically identifiable ones as multicentric in 44. Multicentricity mostly occurred in cases of macroscopically-identifiable nodes located in the central segments of the breast.

[A relationship of squamous-cell metaplasia with the pattern of the course of a respiratory epithelial dysplastic process].

The morphological signs of squamous-cell metaplasia were revealed in 65 out of 193 patients with varying bronchial mucosal changes. A follow-up of the patients indicated that in the group of patients with epithelial dysplasia without squamous-cell metaplasia, the prognosis was good in 65.6% of cases.

[Genetic and clinical and pathological characteristics of breast cancer in premenopausal and postmenopausal women].

This study involved 525 breast cancer (BC) patients of T2-4N0-2M0 stages at the age of 35 years and older. Significant differences in clinical and pathological characteristics between premenopausal and postmenopausal BC patients were found. Mostly marked differences were shown for positive lymph node correlation with distant metastasis, multicentric growth and local recurrence depending on menopause status.

[Assay of matrix metalloproteinase levels and their endogenous inhibitors in patients with laryngeal carcinoma].

Levels of matrix metalloproteinase (MMP-2) and endogenous inhibitors (TIMP-1,-2) in tumor and blood serum from patients with squamous-cell laryngeal carcinoma were studied. Immunohistochemical investigation showed much higher MMP-9 expression (76.9%) and TIMP-1 (100%) in tumor tussue than MMP-2 (23.

Initial morphofunctional asymmetry of the adrenal glands in CBA/Lacy mice.

We performed morphological examination of the adrenal glands from intact CBA/Lacy mice. Morphometry, histochemistry, and electron microscopy revealed predominance of functional activity of the right adrenal gland. This phenomenon was associated with adaptive state of the animals.

Hemopoietic and lymphoid organs in AKR/JY mice with thymic lymphoma.

Cytological and histological studies of the thymus, bone marrow, peripheral blood, spleen, and lymph nodes in 6-9-month-old AKR/JY mice showed that the risk of thymic lymphoma in these animals increased with age. Generalization of the tumor process was observed in mice aged over 8 months and first involved the spleen, then the lymph nodes, bone marrow, and liver. A case of primary lymphoma in the spleen was detected.

[Prognostic significance of immunocompetent cell infiltration of breast tumor tissue].

The prognostic significance of stromal reaction in breast cancer patients has been identified. A reverse correlation between blast lymphocyte level in tumor and metastasis into the regional lymph nodes has been found. Patients with pronounced lympho-histiocytic infiltration receiving combined therapy are expected to have favorable prognosis.

[Effect of electromagnetic fields of a millimeter range on the blood system of animals depending upon their initial state and the zone of irradiation].

As a result of cytological investigations it was discovered that the millimeter range microwaves being applied once during one hour stimulated erythrocytopoiesis of intact mice and induced a change of the lymphocytes number in the blood. The reaction to the microwaves depends on the location of irradiation and animal initial state, which was estimated pertinent to the red blood cells and white blood cells number in the peripheric blood. These factors are of prognostic importance.

[Antirecurrence action of preparations made from Listeria in the surgical removal of sarcoma 180].

It is shown that in spite of the absence of the marked inhibition of the tumour growth in the preparative period listeria preparations decreased the percentage of recurrances. Based on the results obtained a conclusion is drawn that injection of listeria preparations into the tumour for several days before its surgical removal may be an effective prophylactic means of the relapse development.