Publications by authors named "Perchinsky M"

Objectives: To evaluate whether warfarin targeted at an international normalized ratio of 1.8 (range, 1.5-2.

View Article and Find Full Text PDF
Article Synopsis
  • A study aimed to determine if targeting a lower INR of 1.8 (range 1.5-2.0) for warfarin is safe for patients with an On-X aortic mechanical valve, alongside daily aspirin.
  • Researchers tracked 510 patients over an average of 3.4 years, comparing outcomes with those from a prior trial using standard warfarin dosing (INR 2.0-3.0).
  • Results showed a significant reduction in adverse events like thromboembolism and major bleeding, indicating that the lower INR approach could be both safe and effective in this patient group.
View Article and Find Full Text PDF

Background: The purpose of this study was 3-fold: to compare the quality of life (QOL) in age- and sex-matched patients who received biological and mechanical prosthetic valves in isolated aortic valve replacement, to compare the QOL of patients with aortic valve replacement with the general population, and to compare patients with biological and mechanical prostheses with certain valve-specific questions and relate these responses to overall QOL.

Methods And Results: Patient-perceived QOL was evaluated in 200 patients who were sampled from a population of 420 patients (age range 51 to 65 years) who underwent isolated aortic valve replacement in the period of 1986 to 1996. One hundred of the sampled patients had a mechanical valve inserted and an equal number had porcine bioprostheses.

View Article and Find Full Text PDF

Background: Primary cardiac tumors are infrequent, and few cardiac surgeons have extensive experience in treating them. The majority of the tumors are benign. As noninvasive diagnostic imaging of cardiac masses continues to improve, the number of these tumors that are seen by clinicians will increase.

View Article and Find Full Text PDF

Objective: To analyze the factors affecting outcome in patients with blunt cardiac rupture, including anatomical cardiac injury, associated injury, clinical presentation, age, mechanism of injury, diagnostic method, surgical intervention, and presence of vital signs in the field and on arrival.

Design: Retrospective review.

Setting: A community-based level I trauma center.

View Article and Find Full Text PDF

Background: Patients who have massive but potentially survivable injuries frequently die from complications of hypovolemia, hypoxemia, hypothermia, metabolic acidosis, and coagulopathy. Emergency cardiopulmonary bypass has been unsuccessful in preventing such deaths because it involves systemic anticoagulation that exacerbates coagulopathy.

Patients And Methods: A simplified extracorporeal cardiopulmonary life support (ECLS) system was assembled consisting of a centrifugal pump head, heat exchanger, membranous oxygenator, percutaneous cannulas, and heparin-bonded circuitry.

View Article and Find Full Text PDF

Tracheobronchial tree injuries occur in a small number of patients after blunt chest trauma, and their occurrence is even more uncommon in the pediatric trauma population. The authors present the case of a 2-year-old boy who presented with rupture of the trachea and disruption of the right upper lobe bronchus and bronchus intermedius.

View Article and Find Full Text PDF

Two elderly patients, involved in separate motor vehicle accidents, sustained blunt chest injury resulting in rupture of their thoracic aortas. The initial chest radiographs showed the presence of a calcified ring fractured in two places with lateral displacement of a calcified fragment by haematoma. This 'broken halo sign' is a radiographic sign not previously well described in the literature.

View Article and Find Full Text PDF