High-dose prolonged combination therapy in non-responders to interferon monotherapy for chronic hepatitis C.

Background: Therapy of chronic hepatitis C non- responders to interferon monotherapy with standard doses of interferon plus ribavirin is usually ineffective.

Aim: To evaluate the efficacy and tolerability of high-dose prolonged combination retreatment in non- responder patients.

Methods: Patients were retreated for 6 months with 6 MU alphaIFN on alternate days and 1000 or 1200 mg/day ribavirin.

A phase II trial of mitoxantrone plus cyclophosphamide and 5-fluorouracil in modulation with levo-folinate for advanced breast cancer patients.

Advanced breast cancer remains a major clinical problem. Current chemotherapy regimens are able to induce a clinical response in many patients but do not appear to influence significantly patients' survival. The use of new drugs such as mitoxantrone with a predicted lower toxicity and biochemical modulation of 5-fluorouracil with levo-folinate are extensively studied research areas that could combine good therapeutic efficacy with the maintenance of an acceptable quality of life.

A model for characterizing residential ground current and magnetic field fluctuations.

The current through the residential grounding circuit is an important source for magnetic fields; field variations near the grounding circuit accurately track fluctuations in this ground current. In this paper, a model is presented which permits calculation of the range of these fluctuations. A discrete network model is used to simulate a local distribution system for a single street, and a statistical model to simulate unbalanced currents in the system.

Residential exposure to 60-Hz magnetic fields from appliances.

A model has been developed that permits assessment of residential exposure to 60-Hz magnetic fields emitted by appliances. It is based on volume- and time-averaging of magnetic-dipole fields. The model enables the contribution of appliances in the total residential exposure to be compared with that of other sources in any residence under study.