Psychedelic-related deaths in England, Wales and Northern Ireland (1997-2022).

Background: Psychedelic drugs are increasingly visible in society once more, but their risks and adverse effects have received less attention than perhaps they should. While fatalities associated with psychedelics appear rare, a systematic approach to characterising their aetiology is required to inform harm minimisation efforts.

Aims: This study aimed to analyse prevalence and characteristics of psychedelic-related deaths in England, Wales, and Northern Ireland, between 1997 and 2022.

High output power, single mode, and TEM operation of a multiple gain chip VECSEL using a twisted-mode configuration.

A vertical external cavity surface emitting laser (VECSEL) has been developed for a sodium guide star application. Stable single frequency operation with 21 W of output power near 1178 nm with multiple gain elements while lasing in the TEM mode has been achieved. Higher output power results in multimode lasing.

Intra-cavity frequency-doubled VECSEL system for narrow linewidth Rydberg EIT spectroscopy.

High-power, narrow-linewidth light sources in the visible and UV spectra are in growing demand, particularly as quantum information and sensing research proliferates. Vertical external-cavity surface-emitting lasers (VECSELs) with intra-cavity frequency conversion are emerging as an attractive platform to fill these needs. Using such a device, we demonstrate 3.

Watt-level blue light for precision spectroscopy, laser cooling and trapping of strontium and cadmium atoms.

High-power and narrow-linewidth laser light is a vital tool for atomic physics, being used for example in laser cooling and trapping and precision spectroscopy. Here we produce Watt-level laser radiation at 457.75 nm and 460.

Narrow-linewidth operation of folded 1178nm VECSEL with twisted-mode cavity.

A vertical external-cavity surface-emitting laser (VECSEL) with a twisted-mode configuration is demonstrated. This architecture is particularly advantageous for power scaling of single-frequency VECSELs employing multiple gain mirrors in folded cavities. In such a configuration, some of the gain mirrors are inherently at the fold, and the lasing spectrum becomes unstable.

New s-Block Metal Pyridinedicarboxylate Network Structures through Gas-Phase Thin-Film Synthesis.

The combined atomic and molecular layer deposition (ALD/MLD) technique offers a unique way to build-both known and previously unknown-crystalline coordination polymer materials directly from gaseous precursors in a high-quality thin-film form. Here, we demonstrate the ALD/MLD of crystalline Li-, Na-, and K-based 3,5-pyridinedicarboxylate (3,5-PDC) thin films; the Li -3,5-PDC films are of the known Li-ULMOF-4 crystal structure whereas the other as-deposited crystalline films possess structures not previously reported. Another exciting possibility offered by ALD/MLD is the deposition of well-defined but amorphous metal-organic thin films, such as our Mg-, Ca-, Sr-, and Ba-based 3,5-PDC films, which can then be crystallized into water-containing structures through a post-deposition humidity treatment.

Comparison of single-side and double-side pumping of membrane external-cavity surface-emitting lasers.

We studied and compared single-side pumping (SSP) and double-side pumping (DSP) of a semiconductor membrane external-cavity surface-emitting laser (MECSEL). The MECSEL-active region was based on an AlGaAs quantum well structure embedded between two silicon carbide (SiC) wafer pieces that were used as transparent intra-cavity (IC) heat spreaders creating a symmetrical cooling environment. The gain structure targeted emission at 780 nm, a wavelength region that is important for many applications, and where the development of high-brightness high-power laser sources is gaining more momentum.

Brain neurokinin-1 receptor availability in never-medicated patients with major depression - A pilot study.

Background: Neurotransmitter substance P (SP) and its preferred neurokinin-1 receptor (NK1R) have been implicated in the treatment of affective and addiction disorders. Despite promising preclinical data on antidepressant action, the clinical trials of NK1R antagonists in major depression have been disappointing. There are no direct in vivo imaging studies on NK1R characteristics in patients with a major depressive disorder (MDD).

AlGaAs-based vertical-external-cavity surface-emitting laser exceeding 4 W of direct emission power in the 740-790 nm spectral range.

An optically pumped vertical-external-cavity surface-emitting laser (VECSEL) for direct emission in the 740-790 nm wavelength region is reported. The gain structure is based on 12 AlGaAs quantum wells. We demonstrate wavelength tuning between 747 nm and 788 nm and free-running operation with a maximum power of 4.

Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects.

Background: The neuropathology of Alzheimer's disease (AD) has previously been shown to be rather common among the elderly.

Objective: The aim of this study was to inspect the associations between cerebrospinal fluid (CSF) AD biomarker concentrations, age, the APOEɛ4 allele, cardiovascular diseases, diabetes, and cognitive performance in a cohort of a neurologically healthy population.

Methods: This study included 93 subjects (42 men, mean age 67 years) without previous neurological symptoms or subjective cognitive complaints.

1.4 µm continuous-wave diamond Raman laser.

The longest wavelength (~1.4 µm) emitted by a diamond Raman laser pumped by a semiconductor disk laser (SDL) is reported. The output power of the intracavity-pumped Raman laser reached a maximum of 2.

Atomic/Molecular Layer Deposition of s-Block Metal Carboxylate Coordination Network Thin Films.

We present novel atomic/molecular layer deposition (ALD/MLD) processes for the fabrication of crystalline inorganic-organic coordination network thin films with different s-block elements. Terephthalic acid is employed as the organic precursor. Such thin films could enable for example, next-generation battery, sensor and gas-storage technologies.

Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women.

Background: Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correlation of pathological changes in CSF biomarkers with various CERAD-NB subtests and total scores.

Single-centre study reports a 84% five-year overall survival rate for paediatric solid tumours.

Aim: We investigated the characteristics and outcome of paediatric patients with solid tumours diagnosed and treated at the Tampere University Hospital, one of the five tertiary referral centres in Finland, for children and adolescents with malignancies.

Methods: This retrospective cohort study collected data from hospital medical records on survival, diagnosis, age, sex, tumour size and stage at diagnosis. We also observed the disease recurrence and use of autologous haematopoietic stem cell transplantation.

615 nm GaInNAs VECSEL with output power above 10 W.

A high-power optically-pumped vertical-external-cavity surface-emitting laser (VECSEL) generating 10.5 W of cw output power at 615 nm is reported. The gain mirror incorporated 10 GaInNAs quantum wells and was designed to have an emission peak in the 1230 nm range.

The effect of peatland drainage and restoration on Odonata species richness and abundance.

Background: Restoration aims at reversing the trend of habitat degradation, the major threat to biodiversity. In Finland, more than half of the original peatland area has been drained, and during recent years, restoration of some of the drained peatlands has been accomplished. Short-term effects of the restoration on peatland hydrology, chemistry and vegetation are promising but little is known about how other species groups apart from vascular plants and bryophytes respond to restoration efforts.

Checklist of the cecidomyiidae (Diptera) of Finland.

A list of the 356 species of Cecidomyiidae (Diptera) recorded from Finland is presented, which comprises 6 Lestremiinae, 156 Micromyinae, 16 Winnertziinae, 69 Porricondylinae, and 109 Cecidomyiinae. The faunistic knowledge of Finnish Winnertziinae, Porricondylinae and Cecidomyiinae is regarded as particularly poor. Based on species numbers known from other countries in Europe, a conservative estimate is 700-800 species of Cecidomyiidae actually occurring in Finland.

Recent noteworthy findings of fungus gnats from Finland and northwestern Russia (Diptera: Ditomyiidae, Keroplatidae, Bolitophilidae and Mycetophilidae).

New faunistic data on fungus gnats (Diptera: Sciaroidea excluding Sciaridae) from Finland and NW Russia (Karelia and Murmansk Region) are presented. A total of 64 and 34 species are reported for the first time form Finland and Russian Karelia, respectively. Nine of the species are also new for the European fauna: Mycomyashewelli Väisänen, 1984, Mycomyathula Väisänen, 1984, Acnemiatrifida Zaitzev, 1982, Coelosiagracilis Johannsen, 1912, Orfeliakrivosheinae Zaitzev, 1994, Mycetophilabiformis Maximova, 2002, Mycetophilamonstera Maximova, 2002, Mycetophilauschaica Subbotina & Maximova, 2011 and Trichontapalustris Maximova, 2002.

Development of a research dedicated archival system (TARAS) in a university hospital.

Recent healthcare policies have influenced the manner in which patient data is handled in research projects, and the regulations concerning protected health information have become significantly tighter. Thus, new procedures are needed to facilitate research while protecting the confidentiality of patient data and ensuring the integrity of clinical work in the expanding environment of electronic files and databases. We have addressed this problem in a university hospital setting by developing the Tampere Research Archival System (TARAS), an extensive data warehouse for research purposes.

Local extinction of dragonfly and damselfly populations in low- and high-quality habitat patches.

Understanding the risk of extinction of a single population is an important problem in both theoretical and applied ecology. Local extinction risk depends on several factors, including population size, demographic or environmental stochasticity, natural catastrophe, or the loss of genetic diversity. The probability of local extinction may also be higher in low-quality sink habitats than in high-quality source habitats.

Diagnosis and treatment of menorrhagia.

One-third of all women experience heavy menstrual bleeding at some point in their life. In western countries, about 5% of women of reproductive age will seek help for menorrhagia annually. Half of all women who consult for hypermenorrhea have some uterine abnormality, most often fibroids (among patients under 40 years of age) and endometrial polyps (above 40 years of age).

Surgical treatment of ovarian cancer in different hospital categories--a prospective nation-wide study in Finland.

This prospective nation-wide study was performed to evaluate the effect of hospital category and subspeciality training on surgical treatment of ovarian cancer. Data were obtained from a questionnaire filled in by the operating unit, and from the surgical and histopathology reports. The survey included 307 patients.

Deramciclane in the treatment of generalized anxiety disorder: a placebo-controlled, double-blind, dose-finding study.

Deramciclane, a camphor derivative, is a novel anxiolytic agent with a unique mechanism of action. It acts as a potent and specific antagonist at serotonin 5-HT2A/2C receptors, and exhibits anxiolytic efficacy in animal models. The aim of this double-blind, placebo-controlled, parallel-group study was to evaluate the efficacy, safety, and tolerability of a range of doses of deramciclane in patients with generalized anxiety disorder (GAD).