Mental Well-Being of Older People in Finland during the First Year in Senior Housing and Its Association with Physical Performance.

Growing numbers of older people relocate to senior housing, when their physical or mental performance declines. The relocation is known to be one of the most stressful events in the life of older people and affect their mental and physical well-being. More information about the relationships between mental and physical parameters is required.

Social Environment of Older People during the First Year in Senior Housing and Its Association with Physical Performance.

Increasing numbers of older people relocate into senior housing when their physical performance declines. The change in social environment is known to affect their wellbeing, providing both challenges and opportunities, but more information on the relations between social and physical parameters is required. Thus, we elicited perceptions of the social environment of 81 older people (aged 59-93 years, living in northern Finland) and changes in it 3 and 12 months after relocation to senior housing.

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk.

Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the pathogenesis of Helicobacter pylori related gastroduodenal diseases in relation to gastric secretion and inflammation. Toll-like receptor 4 polymorphisms, serum gastrin-17 and pepsinogen I and II concentrations were determined, and gastroscopies with histopathological analyses were performed to 216 dyspeptic patients.

Interleukin 6 gene polymorphism -174 is associated with the diffuse type gastric carcinoma.

The aim of this study was to assess the significance of the interleukin 6 gene polymorphism -174 in gastric cancer risk. The interleukin 6 -174 G/C (rs1800795) gene polymorphisms was analyzed in gastric cancer, peptic ulcer, and nonulcer dyspepsia patients and in healthy control subjects and the data were correlated with the histopathological features of the patients' biopsies. The interleukin 6 -174 GG and GC genotypes have been previously associated with high interleukin 6 serum levels.

Leisure-time physical activity in midlife is related to old age frailty.

Background: There are scarce studies of the long-term associations between leisure-time physical activity (LTPA) in midlife and phenotypic frailty in old age.

Methods: We studied healthy Caucasian men of high socioeconomic status (N = 514), who had participated in health checkups during the 1960s (the Helsinki Businessmen Study, Finland). In 1974, they were examined with questionnaires and clinical examinations, and LTPA was collapsed into three categories: low (n = 87), moderate (n = 256), and high (n = 171).

Physical activity in midlife and telomere length measured in old age.

Physical activity has been associated with alterations in telomere length, a potential indicator of biological aging, but several inconsistencies exist. Our aim was to investigate the associations between physical activity in midlife and leukocyte telomere length (LTL) measured in old age in the Helsinki Businessmen Study, Finland. At entry, in 1974, 782 men (mean age 47) completed a questionnaire about their physical activity and this was collapsed into 3 categories: low (n=148), moderate (n=398) and high physical activity (n=236, 7 of whom had a competitive activity level).

Leisure-time physical activity, cardiovascular risk factors and mortality during a 34-year follow-up in men.

Unlabelled: The inverse relationship between physical activity and mortality may be confounded by socioeconomic factors, cardiovascular risk factors and inverse causality. We investigated long-term association between self-reported regular physical activity and mortality in a socioeconomically homogeneous, initially healthy middle-aged (mean age 47) male cohort (the Helsinki Businessmen Study). In 1974, the men were assessed with questionnaires, clinical and laboratory examinations.

Trends in health status and the use of services among the 80-84-year-old Finnish war veterans during 1992 and 2004.

Aim: The aim of this study was to compare the differences in health state, functional capacity and the use of social and health services among the 80-84-year-old Finnish Second World War veterans in 1992 and 2004 and to describe the possible effects of the improvements made based on the results after 1992.

Methods: The Veteran Projects were conducted among the veterans using a postal questionnaire. In 1992, the questionnaire was sent to all veterans (n = 242,720) living in Finland, and in 2004 to 5750 veterans who had participated in the study in 1992.

Pragmatic exercise-oriented prevention of falls among the elderly: a population-based, randomized, controlled trial.

Objectives: To assess the effectiveness of an intervention planned and implemented by regional geriatric care teams in order to prevent falls in an elderly population.

Methods: The study was conducted among 555 (67%) home-dwelling Finnish persons aged 85 years or older of a representative population sample (N=827) in 2000-2003. Altogether 486 subjects (88%) had a history of recurrent falls or at least one risk factor for disability in the activities of daily living or mobility and were randomly assigned to receive suggestions for a programme consisting of home exercise, walking exercise, group activities or self-care exercise or alternatively routine care.

Prevention of disability by exercise among the elderly: a population-based, randomized, controlled trial.

Objective: To assess the effectiveness of an intervention planned and implemented by regional geriatric care teams in order to prevent disability in an elderly population.

Design: Randomized, controlled trial with intention-to-treat and subgroup analyses. Subjects and setting.

Falls and injurious falls late in home-dwelling life.

Of the Finnish persons aged 85 years or older, living at home, 555 (67% of this age class) were monitored for two years to describe the circumstances and the frequency of falls and injury-causing falls. The incidence rates of falls, major soft tissue injuries and fractures were 1039 (95% confidence interval = CI: 974-1093), 74 (58-92) and 89 (72-108), respectively. The incidence of falls was higher among women 1127 (1055-1199) than among men 755 (651-870), but only among those younger than 90 years.