Publications by authors named "Penson D"
Objectives: Compare functional outcomes and treatment-related regret over 10 years in Spanish- and English-speaking Hispanic men compared to non-Hispanic men following treatment of localized prostate cancer.
Methods And Materials: Data from a prospective cohort study of men with localized prostate cancer treated with active surveillance, radical prostatectomy or radiotherapy were used to examine the effect of survey language (Spanish speaking vs. English speaking) and ethnicity (Hispanic vs.
Article Synopsis
- The study investigates the impact of tobacco smoking on the quality of life and function of prostate cancer survivors, highlighting the need to explore modifiable risk factors like smoking.
- The research utilized data from the CEASAR study involving 2,426 localized prostate cancer patients, categorizing them by their smoking status and analyzing its effect on various health assessments over 5 and 10 years.
- Results indicate that while smoking status had no significant effect on prostate cancer-specific functional outcomes, current smokers exhibited significantly worse physical functioning compared to non-smokers, underlining the negative health impacts of continued smoking during survivorship.
Introduction: Patient preference assessment is key to high-quality decision-making in men with prostate cancer. We aimed to determine if "phenotypes" could be identified among men with prostate cancer, with each phenotype representing a cohort with a distinct combination of preferences. We wished to learn if there was an association between phenotype and treatment selection.
View Article and Find Full Text PDFIntroduction: Financial toxicity associated with treatments for metastatic prostate cancer remains poorly defined. We sought to understand aspects of financial toxicity not captured in a commonly employed financial toxicity questionnaire and identify potential interventions to help alleviate financial toxicity through a convergent mixed methods approach.
Methods: Patients seen at our institution's advanced prostate cancer clinic were approached for completion of the Comprehensive Score for Financial Toxicity (COST-FACIT) questionnaire (quantitative analysis).
Objective: Understand the patient's decision-making process regarding colectomy for recurrent diverticulitis.
Background: The decision to pursue elective colectomy for recurrent diverticulitis is highly preference-sensitive. Little is known about the patient's perspective in this decision-making process.
Importance: Adverse outcomes associated with treatments for localized prostate cancer remain unclear.
Objective: To compare rates of adverse functional outcomes between specific treatments for localized prostate cancer.
Design, Setting, And Participants: An observational cohort study using data from 5 US Surveillance, Epidemiology, and End Results Program registries.
Article Synopsis
- The increase in Grade Group 1 (GG1) prostate cancer cases is largely due to the widespread use of prostate-specific antigen screening, leading to more diagnoses.
- Historically, many GG1 patients underwent unnecessary treatments that negatively impacted their quality of life, as this type of cancer is often very slow-growing and less harmful.
- Active surveillance has emerged as a preferred management approach, focusing on monitoring rather than immediate treatment, and this overview discusses GG1's characteristics and supports the idea of reclassifying it as a non-cancerous condition.
Background: Previsit decision aids (DAs) have promising outcomes in improving decisional quality, however, the cost to deploy a DA is not well defined, presenting a possible barrier to health system adoption.
Objectives: We aimed to define the cost from a health system perspective of delivery of a DA.
Research Design: Observational cohort.
Purpose: Assessments of financial toxicity among patients with metastatic prostate cancer are lacking. Using patient surveys, we sought to identify coping mechanisms and assess characteristics associated with lower financial toxicity.
Materials And Methods: Surveys were administered to all patients seen at a single center's Advanced Prostate Cancer Clinic over a 3-month period.
Article Synopsis
- Combination therapy for advanced prostate cancer improves survival rates, but costs are high, creating financial barriers for patients.
- The Inflation Reduction Act introduces a $2,000 cap on out-of-pocket spending for Medicare prescription drugs starting in 2025, potentially lowering expenses for patients.
- The study found that while some regimens maintain costs, innovative therapies could see significant reductions, with savings up to 79% for certain treatments, benefiting around 25,000 Medicare beneficiaries.
Purpose: Self-administered oncology drugs contribute disproportionately to Medicare Part D spending; prices often remain high even after generic entry. Outlets for low-cost drugs such as Mark Cuban Cost Plus Drug Company (MCCPDC) offer opportunities for decreased Medicare, Part D, and beneficiary spending. We estimate potential savings if Part D plans obtained prices such as those offered under the MCCPDC for seven generic oncology drugs.
View Article and Find Full Text PDFImportance: Specialist palliative care benefits patients undergoing medical treatment of cancer; however, data are lacking on whether patients undergoing surgery for cancer similarly benefit from specialist palliative care.
Objective: To determine the effect of a specialist palliative care intervention on patients undergoing surgery for cure or durable control of cancer.
Design, Setting, And Participants: This was a single-center randomized clinical trial conducted from March 1, 2018, to October 28, 2021.
Purpose: The purpose of this work is to describe the association between body mass index (BMI) and (1) management option for localized prostate cancer (PCa) and (2) disease-specific quality of life (ds-QoL) after treatment or active surveillance.
Subjects/patients And Methods: We analysed data from men with localized PCa managed with radical prostatectomy (RP), radiation therapy (RT), or active surveillance (AS) in a prospective, population-based cohort study. We evaluated the association between BMI and management option with multivariable multinomial logistic regression analysis.
Background: Benign prostatic hyperplasia, lower urinary tract symptoms, and prostate cancer often co-occur. Their effect on urinary function is an important consideration regarding prostate cancer treatment choices. While prostate volume (PV) and urinary symptoms are commonly used in treatment choice decision making, their association with post-treatment urinary function is unknown.
View Article and Find Full Text PDFBackground: Financial toxicity is emerging as an important patient-centered outcome and is understudied in prostate cancer patients. We sought to understand the association between financial burden and treatment regret in men with localized prostate cancer to better evaluate the role of financial discussions in patient counseling.
Methods: Utilizing the Comparative Effectiveness Analysis of Surgery and Radiation dataset, we identified all men accrued between 2011 and 2012 who underwent surgery, radiation, or active surveillance for localized prostate cancer.
Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal carcinoma (IDC), is an aggressive histological subtype that is associated with progression to lethal disease. To delineate the molecular and cellular underpinnings of ICC/IDC aggressiveness, this study examines paired ICC/IDC and benign prostate surgical samples by single-cell RNA-sequencing, TCR sequencing, and histology. ICC/IDC cancer cells express genes associated with metastasis and targets with potential for therapeutic intervention.
View Article and Find Full Text PDFWhat Is This Summary About?: This is a summary of a research article originally published in . The PROSPER study involved men who had a type of advanced prostate cancer called nonmetastatic castration-resistant prostate cancer (nmCRPC). In men with nmCRPC, their cancer has progressed on traditional hormone therapy but scans show that it has not spread to other parts of the body.
View Article and Find Full Text PDFPurpose: Out-of-pocket costs represent an important component of financial toxicity and may impact patients' receipt of care. Herein, we evaluated patient-level factors associated with out-of-pocket costs for contemporary advanced prostate cancer treatment options.
Materials And Methods: We identified all commercially insured men receiving treatment for advanced prostate cancer between 2007 and 2019 within the OptumLabs Data Warehouse®.
Purpose: Data comparing radical prostatectomy and external beam radiation therapy with low dose rate brachytherapy boost are lacking. To better guide shared decision making regarding treatment, we compared patient reported outcomes through 5 years following radical prostatectomy or external beam radiation therapy with low dose rate brachytherapy boost for localized prostate cancer.
Materials And Methods: From 2011-2012, men aged <80 years with localized prostate adenocarcinoma were enrolled and followed longitudinally.
Objective: This study employs qualitative methodology to assess surgeons' perspective on decision making in management of recurrent diverticulitis to improve patient-centered decision making.
Summary Background Data: The decision to pursue colectomy for patients with recurrent diverticulitis is nuanced. Strategies to enact broad acceptance of guidelines for surgery are hindered because of a knowledge gap in understanding surgeons' current attitudes and opinions.