Defining patient-centered, multidimensional success criteria for treatment of chronic spine pain.

Objective: This study aimed to define patient-determined success criteria for treatment of chronic spine pain across four domains: pain, fatigue, emotional distress, and interference with daily activities.

Patients: Seventy chronic spine pain patients were recruited from university-affiliated pain clinics.

Design: The study design was longitudinal, with pretreatment and post-treatment assessments.

Multidimensional success criteria and expectations for treatment of chronic pain: the patient perspective.

Objective: The study's primary objective is to define treatment success from the patient perspective across four domains (pain, fatigue, emotional distress, interference with daily activities) using the Patient Centered Outcomes Questionnaire (PCOQ). Secondary objectives include examination of patient expectations for treatment across domains and derivation of patient subgroups based on PCOQ responses.

Design: Cross-sectional.

AGTR2 mutations in X-linked mental retardation.

Two angiotensin II (Ang II)-specific receptors, AGTR1 and AGTR2, are expressed in the mammalian brain. Ang II actions on blood pressure regulation, water electrolyte balance, and hormone secretion are primarily mediated by AGTR1. The function of AGTR2 remains unclear.