Evidence against a role for ovarian hormones in the regulation of blood flow.

Objective: To determine the effect of ovarian hormone deficiency on peripheral vascular function.

Design: Randomized, single-blind, placebo-controlled.

Setting: General clinical research center.

The effect of hormone replacement therapy on body composition, body fat distribution, and insulin sensitivity in menopausal women: a randomized, double-blind, placebo-controlled trial.

Purpose: After menopause, women gain abdominal fat and become less sensitive to insulin. We sought to determine whether hormone replacement therapy (HRT) reduced intraabdominal and sc abdominal fat and improved insulin sensitivity in early menopausal women.

Methods: Seventy-six postmenopausal women, age 51.