Evaluation of retinal ganglion cell function after intraocular pressure reduction measured by pattern electroretinogram in patients with primary open-angle glaucoma.

Background: To evaluate retinal ganglion cell (RGC) function after intraocular pressure (IOP) reduction measured by pattern electroretinogram (PERG) in patients with newly diagnosed, non-treated preperimetric and early stages of primary open-angle glaucoma (POAG).

Methods: Twenty-four eyes from 24 patients with POAG: 11 eyes with preperimetric glaucoma and 13 eyes with early glaucoma received Ganfort (bimatoprost + timolol) once a day for a period of 1 month. Before and after the treatment, following measurements were analyzed: IOP, mean ocular perfusion pressure (MOPP), peak time of P50 and amplitude of P50 and N95 waves in PERG (ISCEV standard 2012).

Photopic negative response of full-field electroretinography in patients with different stages of glaucomatous optic neuropathy.

Purpose: To evaluate photopic negative response (PhNR) discrimination ability between healthy and glaucomatous patients.

Methods: Ninety eyes of 50 patients with primary open angle glaucoma (POAG) and 45 eyes of 23 healthy age- and sex-matched controls were investigated. Based on European Glaucoma Society criteria, POAG patients were divided into three groups: early, moderate and advanced glaucoma.

Visual evoked potentials in a diagnosis of a visual pathway dysfunction of a child with an arachnoid cyst.

Purpose: The aim of this case report was to demonstrate the usefulness of the flash visual evoked potentials in monitoring the effects of intracranial hypertension in a preterm-born child with a congenital arachnoid cyst.

Methods And Results: At baseline, abnormalities were found in the right eye: exotropia and lack of foveal fixation. Visual acuity was not achieved.

Electrophysiological tests in evaluation of glaucoma and ocular hypertension treatment--up to date knowledge. A review.

Purpose: On the basis of the literature data to assess the efficacy of the electrophysiological tests (pattern electroretinogram, multifocal electroretinogram and multifocal visual evoked potentials) in evaluation of retinal ganglion cells function in glaucomatous and ocular hypertension eyes, after intraocular pressure reduction.

Material And Methods: Data published in the literature available at the Pub Med library between 1964-2012.

Results: Several results of studies suggest, that steady-state pattern electroretinogram reveals significant improvement of retinal ganglion cells function after treatment with timolol, acatazolamide, beta-blockers and prostaglandin analogues.

Evaluation of treatment efficacy of intravitreal ranibizumab injections in patients with wet type of AMD.

Purpose: To evaluate foveal function, retinal circulation and foveal thickness before and after intravitreal ranibizumab injections in eyes with wet type of age-related macular degeneration (AMD).

Material And Methods: The study group consisted of 21 eyes (20 patients) with choroidal neovascularisation (CNV) due to AMD. Inclusion criteria were based on fluorescein angiography (FA) and distance best corrected visual acuity (DBCVA)--log MAR scale.

The photopic negative response as a promising diagnostic tool in glaucoma. A review.

Purpose: Based on the available literature, the clinical usefulness of Photopic Negative Response (PhNR) of flash Electroretinogram (ERG) in detecting glaucoma has been described.

Materials And Methods: Data published in the literature available at the Pub Med library between 1999-2011. Different techniques of eliciting, assessing and measuring PhNR have been analyzed.

Topical dorzolamide treatment of macular cysts in the enhanced S-cone syndrome patient.

Purpose: The purpose of the study was to evaluate the efficacy of a topical form of a carbonic anhydrase inhibitor (dorzolamide) on the foveal function and thickness in the eye of a patient with enhanced S-cone syndrome (ESCS) associated with macular cysts.

Methods: Twenty-eight-year-old Polish man with ESCS and macular cysts appearance in the right eye was treated 3 times daily with 2.0 % dorzolamide drops for the period time equal to 6 months.

Retinal ganglion cells function measured by the PERG test in patients with ocular hypertension.

Purpose: To assess the retinal ganglion cells function in patients with ocular hypertension (OHT).

Material And Methods: In one hundred eyes of 50 patients with ocular hypertension [mean age: 48 +/- 13 years, intraocular pressure mean: 26 +/- 3.0 mmHg; Humphrey Field Analyzer (HFA) 24-2 W-W mean deviation (MD) > -2 decibels (dB), normal optic nerve fiber layer results in scanning laser polarimetry (GDX)], PERG recordings were performed according to the modified methodology described by Parisi V et al.

[Functional improvement of injured retina following the adjuvant stem cell-based therapy. Preliminary report].

Purpose: The purpose of this study was to appraise the functional response of damaged retina to the stem cell-based therapy in mice. The majority of disorders leading to the irreversible vision loss in the developed world is caused by retinal degeneration. Since, recent reports emphasized regenerative potential of bone marrow stem marrow stem/progenitor cells (SPCs), we investigated here the beneficial effect of intravenously administrated SPCs on regeneration of acutely injured retina.

Sodium iodate selectively injuries the posterior pole of the retina in a dose-dependent manner: morphological and electrophysiological study.

Sequential morphological and functional features of retinal damage in mice exposed to different doses (40 vs. 20 mg/kg) of sodium iodate (NaIO(3)) were analyzed. Retinal morphology, apoptosis (TUNEL assay), and function (electroretinography; ERG) were examined at several time points after NaIO(3) administration.

A 43-year-old man with reduced visual acuity and normal fundus: occult macular dystrophy--case report.

Purpose: Occult macular dystrophy (OMD) is an unusual, inherited macular dystrophy characterized by a slowly progressive decline of visual acuity with normal fundus and fluorescein angiography (FA). The authors present a 43-year-old man who was diagnosed as having OMD because of the results of electrophysiological, psychophysical, optical coherence tomography (OCT) tests.

Methods: Routine ophthalmological evaluation, FA, visual field tests, electroretinographic examinations (EOG, ERG, PERG and mfERG recordings according to ISCEV standards) and foveal thickness measurements (OCT) were performed.

[Computer fusion of the mfVEP and HVF images].

Introduction: The purpose of this paper is to show a method of data fusion from two different tests: the multifocal visual evoked potentials (mfVEP) and humphrey visual field (HVF). Fusing the results may lead to a better diagnosis of various diseases associated with changes of patient's field-of-view.

Material And Methods: Two methods were used: mfVEP and HVF.

[Improvement of the PERG parameters measurement accuracy in the continuous wavelet transform coefficients domain].

Purpose: To determine parameters of the pattern electroretinogram (PERG) waveforms in the continuous wavelet transform (CWT) coefficients domain important in more precise clinical assessment of the recordings.

Material And Methods: 102 normal PERG recordings were studied in two age groups (< or = 50 years, > 50 years). Continuous wavelet transform analysis was performed using the MatLab 7.

Retinal dysfunction in eyes of patients with BRCA1 gene mutation.

Purpose: To assess the retinal function in BRCA1 gene mutation carriers.

Material And Methods: Thirty unaffected patients (60 eyes) with constitutional BRCA1 gene mutation were studied. Flash ERG recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards.

Supernormal electro-oculograms in patients with neurofibromatosis type 1.

Purpose: To asses the retinal pigment epithelium (RPE) function measured by EOG testing in patients with neurofibromatosis type 1 (NF-1). Our preliminary EOG results suggested dysfunction of the RPE in individuals with NF-1. In order to confirm our initial results we performed EOG examination on a larger group of NF-1 patients.

Electro-oculographic and electroretinographic studies in HNPCC gene mutation carriers.

Purpose: To assess retinal function in HNPCC gene mutation carriers.

Patients: 19 carriers (38 eyes) of HNPCC genes and controls.

Methods: Electro-oculogram, standard flash electroretinogram and pattern electroretinogram (PERG) recordings were performed.

Retinal function in the von Hippel-Lindau disease.

Purpose: To assess the retinal function in patients with von Hippel-Lindau disease (VHL).

Patients: Studies were undertaken in 12 patients (17 eyes) with detected VHL gene mutation and 12 normal healthy controls (17 eyes).

Methods: Pattern ERG (PERG), standard flash electroretinogram (ERG) recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards.

Electroretinographic changes in eyes of patients with BRCA1 gene mutation.

Aim: To assess the retinal function in BRCA1 gene mutation carriers and to evaluate the clinical significance of its potential alterations.

Patients And Methods: Flash electroretinogram (ERG) was studied in 15 unaffected patients (30 eyes) with constitutional BRCA1 gene mutation. Routine ophthalmological examination was additionally performed in the oldest, unaffected 15 patients and in 15 breast cancer patients being carriers of BRCA1 mutation.

Electroretinographic changes in the inner retinal layers of the retained eyes of patients with sporadic unilateral retinoblastoma.

Purpose: Examination of retinal function as measured by flash electroretinogram (ERG) including oscillatory potentials (OPs) and pattern electroretinogram (PERG) in a series of patients with unilateral sporadic retinoblastoma.

Patients: Studies were undertaken in the retained eye (without clinical evidence of retinoblastoma) of 13 patients with sporadic unilateral retinoblastoma and in 13 healthy controls.

Methods: Standard flash ERG including scotopic OPs and PERG recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards.