Curing simulation and data-driven curing curve prediction of thermoset composites.

Molding has been widely used to manufacture thermoset composite structures in the aerospace and automotive industries owing to its efficiency in reducing the number of parts and the manufacturing cost. For such molded composite parts, the degree-of-cure curve is generally used to evaluate the solidification of the resin. Nevertheless, in simulation of cure is not the cure model itself, but rather knowing the initial conditions such as fiber volume fraction, initial curing degree, convective boundary conditions etc.

Duhuo Jisheng Decoction in reduction of inflammatory response via Transforming growth factor-β/Smad signaling pathway for repairing rabbit articular cartilage Injury: A Randomized Controlled Trial.

Objective: This study aims to investigate the mechanism underlying the effect of Duhuo Jisheng Decoction on the repair of rabbit articular cartilage injury through a reduction in the inflammatory response mediated by the Transforming growth factor (TGF)-β/Smad signaling pathway.

Methods: A rabbit articular cartilage injury model was constructed using a ring bone extraction drill. Twenty-four Japanese white rabbits were randomly divided into six groups, namely Sham operation, model, low-dose Duhuo Jisheng Decoction, medium-dose Duhuo Jisheng Decoction, high-dose Duhuo Jisheng Decoction, and positive control groups.

Antioxidative hydrogel based on hyaluronic acid/polyethylene glycol loaded with shikonin-coated flexible liposome and evaluation of its therapeutic effect on eczema.

Eczema, a common skin condition, is gaining attention due to its increasing annual prevalence and severe influence on both bodily and mental health. Existing treatments for this disease often have significant side effects and safety concerns. Comfrey, a traditional Chinese herbal remedy, is commonly used to treat skin conditions.

Exploring m6A methylation in skin Cancer: Insights into molecular mechanisms and treatment.

N6-methyladenosine (m6A) is the most common and prevalent internal mRNA modification in eukaryotes. m6A modification is a dynamic and reversible process regulated by methyltransferases, demethylases, and m6A binding proteins. Skin cancers, including melanoma and nonmelanoma skin cancers (NMSCs), are among the most commonly diagnosed cancers worldwide.

Exploring the roles and potential therapeutic strategies of inflammation and metabolism in the pathogenesis of vitiligo: a mendelian randomization and bioinformatics-based investigation.

Introduction: Vitiligo, a common autoimmune acquired pigmentary skin disorder, poses challenges due to its unclear pathogenesis. Evidence suggests inflammation and metabolism's pivotal roles in its onset and progression. This study aims to elucidate the causal relationships between vitiligo and inflammatory proteins, immune cells, and metabolites, exploring bidirectional associations and potential drug targets.

Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study.

Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects the elderly. However, the relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, which included only European populations, was to assess the potential causative link between BP and 13 types of malignant tumors in a two-sample Mendelian randomization (MR) study.

Hypervalent Fluoro-iodane-Triggered Semipinacol Rearrangements: Synthesis of α-Fluoro Ketones.

Hypervalent fluoro-λ-iodanes have emerged as versatile reagents that provide unusual fluorination selectivities under mild reaction conditions. Here, we report on adding a semipinacol rearrangement, fluorination, and aryl migration cascade reaction of styrene derivatives. Thus, various cyclopentanones became accessible in up to 96% yield, all bearing tertiary ,-carbon centers adjacent to the ketone group.

Exosomal lncRNA HOTAIR induces PDL1 B cells to impede anti-tumor immunity in colorectal cancer.

Regulatory B cells (Bregs) contribute to tumor immunosuppression. However, how B cells acquire their regulatory features in tumors remain unclear. Exosomes are important messengers that transmit tumor information to remodel tumor immunity.

Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion.

Immunoregulatory B cells impede antitumor immunity through unknown features and mechanisms. We report the existence of leucine-tRNA-synthase-2 (LARS2)-expressing B cell (LARS B) subset with a transforming growth factor-β1 (TGF-β1)-dominant regulatory feature in both mouse and human progressive colorectal cancer (CRC). Of note, LARS B cells exhibited a leucine nutrient preference and displayed active mitochondrial aminoacyl-tRNA biosynthesis.

Alveolar soft tissue sarcoma: a report of 50 cases at a single institution.

Background: Alveolar soft-part sarcoma (ASPS) is a rare soft tissue sarcoma subtype, occurring mainly in young people, with poor prognosis.

Materials And Methods: We conducted a retrospective analysis of localized or metastatic ASPS patients admitted to the First Affiliated Hospital of Zhengzhou University (China) from 2012 to 2020, focusing on treatment and prognosis.

Results: The median age at diagnosis was 24 years (range: 1.

Complete chloroplast genome sequence of an important medicinal plant.

is a perennial herbaceous plant belonging to the genus Peganum, Nitrariaceae and is mainly distributed in dry areas in the Mediterranean and many Asia countries. This plant species has high medicinal value and considerable ecological value. This article reports the first chloroplast genome of species in Peganum.

Dechlorane Plus Biomagnification and Transmission through Prairie Food Webs in Inner Mongolia, China.

Dechlorane Plus (DP) is found widely in the environment. It is important to study DP enrichment and biomagnification in terrestrial ecosystems to improve our understanding of the possible effects of DP on the environment and human health. A total of 90 samples, including plant and animal tissues, were collected from Xilingol Prairie in Inner Mongolia, China.

Distributions and biomagnification of polybrominated diphenyl ethers in a grassland ecosystem food chain.

The concentrations, distributions, and biomagnification of polybrominated diphenyl ethers (PBDEs) in environmental and biological media in a terrestrial grass ecosystem were studied, The total PBDE concentrations in grasses were 4.00 × 10 to 4.28 ng·g.

TRAF4, a new substrate of SIAH1, participates in chemotherapy resistance of breast cancer cell by counteracting SIAH1-mediated downregulation of β-catenin.

Purpose: TRAF4 plays an important role in the development and progression of breast cancer, but its impact on chemotherapy resistance is as yet, however, poorly understood.

Methods: Western blotting, immunoprecipitation, and immunofluorescence staining were used to identify and verify that TRAF4 was a novel substrate of SIAH1 and prevented SIAH1-mediated β-catenin degradation. Cell proliferation analysis and Flow cytometry analysis were utilized to detect TRAF4's function on the growth-inhibitory effect of etoposide.

Competitive Adsorption as a Route to Area-Selective Deposition.

In this work, we have explored the use of a third species during chemical vapor deposition (CVD) to direct thin-film growth to occur exclusively on one surface in the presence of another. Using a combination of density functional theory (DFT) calculations and experiments, including in situ surface analysis, we have examined the use of 4-octyne as a coadsorbate in the CVD of ZrO thin films on SiO and Cu surfaces. At sufficiently high partial pressures of the coadsorbate and sufficiently low substrate temperatures, we find that 4-octyne can effectively compete for adsorption sites, blocking chemisorption of the thin-film precursor, Zr[N(CHCH)], and preventing growth on Cu, while leaving growth unimpeded on SiO.

Polychlorinated biphenyls in a grassland food network: Concentrations, biomagnification, and transmission of toxicity.

The production of polychlorinated biphenyls (PCBs) is prohibited by the Stockholm Convention in 2001, but the unintentionally produced PCBs are still continuously discharged into the environment. In this study, the distributions, biomagnification and toxicity amplification in a grassland food network (including inorganic environment, animals and vegetation) were investigated. PCB concentrations in various samples were determined, and PCBs appeared to be enriched as the trophic level increased.