Clinical Value of lncRNA CASC19 in Myocardial Infarction and its Role in Myocardial Infarction-Induced Cardiomyocyte Apoptosis.

To explore the effect of long non-coding RNA cancer susceptibility 19 (lncRNA CASC19) on the activity, apoptosis, and oxidative stress response of cardiomyocytes, so as to assess the clinical relevance and molecular mechanism of CASC19 in myocardial infarction (MI). CASC19 level was determined by using real-time quantitative polymerase chain reaction (RT-qPCR). MI model was constructed using hypoxia induction, and rat cardiomyocytes H9c2 were divided into control group, MI group, MI small interference negative control (MI-si-NC) group, MI-si-CASC19 group, MI-si-CASC19+microRNA-NC (miR-NC) group, and MI-si-CASC19+miR-218-5p inhibitor group.

Strategies for improving the superconductivity of hydrides under high pressure.

The successful prediction and confirmation of unprecedentedly high-temperature superconductivity in compressed hydrogen-rich hydrides signify a remarkable advancement in the continuous quest for attaining room-temperature superconductivity. The recent studies have established a broad scope for developing binary and ternary hydrides and illustrated correlation between specific hydrogen motifs and high-s under high pressures. The analysis of the microscopic mechanism of superconductivity in hydrides suggests that the high electronic density of states at the Fermi level (E), the large phonon energy scale of the vibration modes and the resulting enhanced electron-phonon coupling are crucial contributors towards the high-phonon-mediated superconductors.

High-temperature superconductivities and crucial factors influencing the stability of LaThH under moderate pressures.

The recent discovery of high-temperature superconductivity in compressed hydrides has reignited the long-standing quest for room-temperature superconductors. However, the synthesis of superconducting hydrides under moderate pressure and the identification of crucial factors that affect their stability remain challenges. Here, we predicted the ternary clathrate phases of LaThH with potential superconductivity under high pressures and specifically proposed a novel 3̄-LaThH phase exhibiting a remarkable of 54.

Structural predictions of three medium-sized thiolate-protected gold nanoclusters Au(SR), Au(SR), and Au(SR).

The knowledge of structural evolution among thiolate-protected gold nanoclusters is not only helpful for understanding their structure-property relationship but also provides scientific evidence to rule-guided structure predictions of gold nanoclusters. In this paper, three new atomic structures of medium-sized thiolate-protected gold nanoclusters, Au(SR), Au(SR), and Au(SR), are predicted based on the grand unified model and ring model. Two structural evolution rules, , Au(SR) + [Au(SR)] → Au(SR) + [Au(SR)] → Au(SR) and Au(SR) + [Au(SR)] → Au(SR) + [Au(SR)] → Au(SR) + [Au(SR)] → Au(SR), are explored.

Isomerism effects in relaxation dynamics of Au(SR)thiolate-protected gold nanoclusters.

Understanding the excited state behavior of isomeric structures of thiolate-protected gold nanoclusters is still a challenging task. In this paper, based on grand unified model and ring model for describing thiolate-protected gold nanoclusters, we have predicted four isomers of Au(SR)nanoclusters. Density functional theory calculations show that the total energy of one of the predicted isomers is 0.

[Au(SR)] Ring as a New Type of Protection Ligand in a New Atomic Structure of Au(SR) Nanocluster.

We present a [Au(SR)] ring as a new type of protection ligand in a new atomic structure of Au(SR) nanocluster for the first time based on the ring model developed to understand how interfacial interaction dictates the structures of protection motifs and gold cores in thiolate-protected gold nanoclusters. This new Au(SR) model shows a tetrahedral Au core protected by one [Au(SR)] ring and two [Au(SR)] "staple" motifs. Density functional theory (DFT) calculations show that the newly predicted Au(SR) (R = CH/Ph) has a lower energy of 0.

Unraveling the Atomic Structures of 10-Electron (10e) Thiolate-Protected Gold Nanoclusters: Three Au(SR) Isomers, One Au(SR), and One Au(SR).

The atomic structures of 10-electron (10e) thiolate-protected gold nanoclusters have not received extensive attention both experimentally and theoretically. In this paper, five new atomic structures of 10e thiolate-protected gold nanoclusters, including three Au(SR) isomers, one Au(SR), and one Au(SR), are theoretically predicted. Based on grand unified model (GUM), four Au cores with different morphologies can be obtained via three different packing modes of five tetrahedral Au units.

Ring Model for Understanding How Interfacial Interaction Dictates the Structures of Protection Motifs and Gold Cores in Thiolate-Protected Gold Nanoclusters.

Understanding the effect of interfacial interactions between the protection motifs and gold cores on the stabilities of thiolate-protected gold nanoclusters is still a challenging task. Based on analyses of 95 experimentally crystallized and theoretically predicted thiolate-protected gold nanoclusters, we present a ring model to offer a deeper insight into the interfacial interactions for this class of nanoclusters. In the ring model, all the gold nanoclusters can be generically viewed as a fusion or interlocking of several [Au(SR)] ( = 4-8, 10, and 12 and 0 ≤ ≤ ) rings.

Two-dimensional growth mode of thiolate-protected gold nanoclusters Au(SR) ( = 0-8): compared with their one-dimensional growth mode.

In this paper, six new atomic structures of thiolate-protected gold nanoclusters, i.e. Au32(SR)20, Au40(SR)26, Au48(SR)30, two Au56(SR)34, and Au60(SR)36, are predicted.