Quorum Sensing Mediates Interaction with In Vitro.

and are opportunistic pathogens that cause severe infections in hospitals, and their co-infections are increasingly reported. The interspecies interactions between these two bacterial species and their potential impacts on infections are largely unexplored. In this study, we first demonstrated that inhibits the growth of by iron chelating via quorum sensing.

The AhR ligand phthiocol and vitamin K analogs as quorum sensing inhibitors.

The aryl hydrocarbon receptor (AhR) protein senses microbial-secreted metabolites to trigger the host's innate immune system. The quinolone signal (PQS) and (MTb) metabolite phthiocol (Pht) are both ligands of AhR with similar chemical structures. As PQS is an essential quorum-sensing molecule that regulates a wide range of virulence factors in , we hypothesized that Pht and its analogs are potential quorum-sensing inhibitors (QSIs) with immune-modulating functions.