Publications by authors named "Pengyan Xu"
Liver metastasis occurs frequently in patients with pancreatic cancer. We analyzed the molecular profiling in liver metastatic lesions aiming to uncover novel genes responsible for tumor progression. Bioinformatics analysis was applied to identify genes directing liver metastasis.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers used CRISPR/Cas9 screening to identify key genes affecting gemcitabine resistance in pancreatic cancer cells, pinpointing deoxycytidine kinase (DCK) and cyclin L1 (CCNL1) as significant factors.
- * Knockout experiments showed that loss of DCK or CCNL1 increases gemcitabine resistance, with a focus on CCNL1 revealing that its absence activates the ERK/AKT/STAT3 survival pathway, further complicating treatment.
Recurrent metastasis is a major fatal cause of breast cancer. Regretfully, the driving force and the molecular beneath have not been fully illustrated yet. In this study, a cohort of breast cancer patients with locoregional metastasis was recruited.
View Article and Find Full Text PDFPlant phenological records are crucial for predicting plant responses to global warming. However, many historical records are either short or replete with data gaps, which pose limitations and may lead to erroneous conclusions about the direction and magnitude of change. In addition to uninterrupted monitoring, missing observations may be substituted via modeling, experimentation, or gradient analysis.
View Article and Find Full Text PDF