Publications by authors named "Pengyan He"
Adult hippocampal neurogenesis (AHN), the process of generating new neurons from adult neural stem/progenitor cells (NSPCs), is crucial for cognitive functions and is influenced by numerous factors, including metabolic processes. Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme in glycolysis, catalyzes the production of pyruvate, which undergoes either oxidative phosphorylation or anaerobic oxidation. We observed that PKM2 is highly expressed in NSPCs, but its significance remains unclear for AHN and cognition.
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- * A study found a significant correlation between levels of C3a, a breakdown product of complement C3, and cognitive impairments in NMO patients, indicating that C3a may negatively impact neuronal development.
- * Reducing C3 levels in astrocytes improved cognitive functions and neuronal development in mouse models of NMO, suggesting that targeting the C3-C3aR signaling pathway could be a viable treatment strategy for cognitive impairments associated with autoimmune diseases like NMO.
Objective: Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin and doxorubicin on mouse macrophages.
Methods: RAW 264.