Publications by authors named "Pengxi Zheng"
Acute kidney injury (AKI) is a complex renal disease. Long non-coding RNAs (lncRNAs) have frequently been associated with AKI. In the present study, we aimed to investigate the molecular mechanism(s) of LINC00052 in AKI.
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- Diabetic nephropathy (DN) is a serious kidney disease linked to diabetes, where abnormal processes in mesangial cells worsen the condition.
- The study found that MIAT is up-regulated in DN patients and high glucose-treated mesangial cells, and silencing MIAT reduces abnormal cell growth and fibrosis triggered by high glucose levels.
- MIAT acts as a sponge for miR-147a, which is reduced in DN, and the loss of MIAT rescues the effects of high glucose, highlighting a pathway where MIAT promotes harmful cell behavior by regulating miR-147a and its target, E2F transcription factor 3 (E2F3).
The current study aimed to investigate the role and underlying mechanisms of circ_LARP4 in diabetic nephropathy (DN). Here, mouse mesangial cells (SV40-MES13) were cultured with 30 mM glucose to establish a DN cellular model. The qRT-PCR results indicated that circ_LARP4 expression was downregulated in the DN cellular model compared to that in the control cells.
View Article and Find Full Text PDFRecently, microRNAs have been recognized as crucial regulators of diabetic nephropathy (DN) development. Epithelial-to-mesenchymal transition (EMT) can play a significant role in tubulointerstitial fibrosis, and it is a hallmark of diabetic nephropathy progression. Nevertheless, the function of miR-98-5p in the modulation of EMT and renal fibrosis during DN remains barely investigated.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) play vital roles in diabetic nephropathy (DN). This research aimed to study the potential role and underlying molecular mechanisms of long non-coding RNA MEG3 in DN. We found that MEG3 was upregulated in DN in vivo and in vitro and could enhance cell fibrosis and inflammatory response in DN.
View Article and Find Full Text PDFDiabetic nephropathy (DN) is serious diabetic complication with capillary injury. Podocyte injury exerts a crucial effect on DN pathogenesis. MicroRNA-503 (miR-503) has been reported in various diseases including DN.
View Article and Find Full Text PDFCoexistence of Graves' Disease in a 14-year-old young girl with Gitelman Syndrome.
Clin Endocrinol (Oxf)
December 2015