Publications by authors named "Pengtao Lin"
Postoperative cognitive dysfunction (POCD) is a common complication with no effective treatment in elderly patients. POCD, Alzheimer disease (AD), and many other cognitive diseases mostly involve neurotoxic microglia response, and recently, β2-microglobulin (B2M) has been suggested to play a pivotal role. A novel pyromeconic acid-styrene hybrid compound D30 was synthesized by our team and shown to be safe and effective in some neurodegenerative mouse models.
View Article and Find Full Text PDFVague-Segment Technique: Automatic Computation of Tumor Stroma Ratio for Breast Cancer on Whole Slides.
IEEE J Biomed Health Inform
February 2024
The calculation of Tumor Stroma Ratio (TSR) is a challenging medical issue that could improve predictions of neoadjuvant chemotherapy benefits and patient prognoses. Although several studies on breast cancer and deep learning methods have achieved promising results, the drawbacks that pixel-level semantic segmentation processes could not extract core tumor regions containing both tumor pixels and stroma pixels make it difficult to accurately calculate TSR. In this paper, we propose a Vague-Segment Technique (VST) consisting of a designed SwinV2UNet module and a modified Suzuki algorithm.
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- The study aimed to evaluate and rank various non-pharmacological methods for relieving pain after cardiac surgery, focusing on comprehensive comparisons among those interventions.
- Previous reviews showed non-pharmacological treatments reduce pain, but this research quantitatively compared their effectiveness for the first time.
- Results indicated that transcutaneous electrical nerve stimulation is the most effective method, followed by acupressure and music therapies, but none of the interventions significantly reduced opioid use or anxiety levels.
Metal-oxide (MO) semiconductor gas sensors based on chemical resistivity necessarily involve making electrical contacts to the sensing materials. These contacts are imperfect and introduce errors into the measurements. In this paper, we demonstrate the feasibility of using contactless broadband dielectric spectroscopy (BDS)-based metrology in gas monitoring that avoids distortions in the reported resistivity values due to probe use, and parasitic errors (i.
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- Coronary artery disease (CAD) is linked to the buildup of atherosclerotic plaques in coronary arteries, driven by the abnormal growth and death of vascular smooth muscle cells (VSMCs).
- MicroRNA-574-5p (miR-574-5p) levels are significantly increased in patients with CAD, suggesting a connection to disease severity, yet the exact role of miR-574-5p in CAD remains unclear.
- Research findings indicate that miR-574-5p enhances VSMC proliferation and reduces apoptosis by targeting the ZDHHC14 gene, positioning it as a potential therapeutic target for CAD.
Article Synopsis
- The study aimed to determine if monitoring end-tidal sevoflurane (ETS) could lower the risk of intraoperative awareness during general anesthesia in endoscopic surgery.
- Approximately 2500 patients were split into two groups: one with ETS monitoring (Group E) and one with routine care (Group R).
- Results showed that group E had significantly fewer instances of intraoperative awareness (2 cases) compared to group R (14 cases), suggesting that ETS monitoring effectively reduces awareness without impacting other anesthesia parameters.
Background: our research aim to study the role of AQP1 in the cardioprotective effect of remifentanil post-conditioning for myocardial ischemia/reperfusion injury.
Methods: Ninety Sprague-Dawley (SD) rats were divided into 6 groups: sham operation group (Sham group), myocardial ischemia and reperfusion group (I/R group), postconditioning of remifentanil group (R-post), postconditioning of remifentanil plus AQP1 inhibitor acetazolamide group (R-post +Ace), postconditioning of remifentanil plus opioid-receptor antagonist compounds (R-post +AC), postconditioning of remifentanil plus AQP1 enhancer arginine vasopressin (R-post +AV). All groups except the sham operation group were given 30 min ischemia in left anterior descending (LAD) coronary arteries.
[Effects of sevoflurane preconditioning on cardiomyocyte apoptosis and myocardial inflammation in rats with sepsis].
Nan Fang Yi Ke Da Xue Xue Bao
November 2014
Article Synopsis
- The study investigates the impact of sevoflurane preconditioning on heart cell death and inflammation in rats with sepsis.
- Forty rats were divided into four groups, with varying treatments including a control and two sevoflurane concentration levels.
- Results showed that sevoflurane reduced heart injury by lowering the levels of markers related to cell death and inflammation, particularly at higher concentrations.
Purpose: Remifentanil is known to cause vasodilation at standard anesthetic concentrations. The intracellular mechanisms underlying its vasodilator action may involve the activation of ion channels. The purpose of this study was to examine whether remifentanil inhibits L-type calcium channels (Ca.
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