Angucyclinones with IDO and TDO inhibitory activities isolated from the actinomycetes Umezawaea beigongshangensis.

Four previously undescribed angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined by spectroscopic analyses, single crystal X-ray diffraction, quantum chemical C NMR and electronic circular dichroism calculations. All compounds displayed strong inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assay, especially compound 2.

Epicoccanes A-D, Four Oxidative Dimers of Pyrogallol Analogues from .

Epicoccanes A-D (-) are four novel metabolites of an endophytic fungus . Their distinct unprecedented structures are hypothesized as oxidative dimers of pyrogallol analogues. Compounds and possess a novel spirobicyclo[3.

Beetleane A and Epicoane A: Two Carbon Skeletons Produced by .

Two novel natural products, beetleane A () and epicoane A (), were obtained from the metabolites of an endophytic . Compound has a unique beetlelike structure that is constructed by the fusion and further fold of an unusual [5.5.

Chemical constituents and coagulation activity of Lindl flowers.

The leaves and bark of Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of because of its abundant resource, however, less reports about the components of flowers. The previous studies on flowers were mainly focused on the volatile components and its traditional pharmacological activity.

Chemical constituents and coagulation activity of Agastache rugosa.

Background: In the Chinese traditional medicine, plant of Agastache rugosa (Fisch. & C.A.

Analysis of tilianin and acacetin in by high-performance liquid chromatography with ionic liquids-ultrasound based extraction.

Ionic liquid 1-butyl-3-methylimidazolium bromide-methanol-based ultrasonic-assisted extraction (ILUAE) was used to extract tilianin and acacetin from the aerial parts of (), and simultaneously determined by reversed phase high performance liquid chromatographic (RP-HPLC) method with ultraviolet detection (RP-HPLC-UV). An InertSustain RP-C column was used with the mobile phase consisting of methanol and 0.2% acetic acid as gradient elution at the detection wavelength of 332 nm.