An In-Plane Heterostructure NiN/MoSe Loaded on Nitrogen-Doped Reduced Graphene Oxide Enhances the Catalyst Performance for Hydrogen Oxidation Reaction.

Non-noble metal electrocatalysts for the hydrogen oxidation reaction (HOR) that are both highly active and low-cost are essential for the widespread use of fuel cells. Herein, a simple two-step method for creating an in-plane heterostructure of NiN/MoSe loaded on N-doped reduced graphene oxide (NiN/MoSe@N-rGO) as an effective electrocatalyst for the HOR is described. The process involves hydrothermal treatment of the Ni and Mo precursors with N-doped reduced graphene oxide, followed by the annealing with urea.

Pharmacokinetics and safety of pirfenidone in individuals with chronic kidney disease stage G2 and G3a: A single-dose, Phase I, bridging study.

Background And Objective: Pirfenidone is an inhibitor of transforming growth factor-beta 1 (TGF-β1) and is being developed for the treatment of diabetic kidney disease (DKD). We assessed the pharmacokinetics (PK) and safety of a single dose of pirfenidone in individuals with CKD stages G2/G3a.

Methods: In this phase I bridging study, patients with CKD stages G2 or G3a, aged 18-70 years, with a body mass index of 18-26 kg/m, and glomerular filtration rate (eGFR) ranging from 45 to 89 ml/min/1.

M6A Modification and Transcription Analysis of LncRNA in Cerebral Ischemia/Reperfusion Injury.

LncRNA is a major factor in the occurrence and development of many diseases. However, its mechanism in cerebral ischemia/reperfusion injury (CIRI) is yet unknown. In this study, the transcriptional level and methylation modification level of LncRNAs before and after mechanical thrombectomy were compared by high-throughput sequencing.

Bioinspired molecular catalysts with a unique tricopper architecture for highly efficient oxygen reduction reaction.

growth of intertwined trinuclear copper complexes (nCu) on a cellulose-derived carbon support (CMC) produced a high-performance electrocatalyst (CMC-nCu) for the oxygen reduction reaction (ORR), which demonstrated superior performance in zinc-air batteries compared to a commercial Pt/C catalyst. This work highlights the importance of copper-based molecular catalysts with rich and intertwined tricopper structures for boosting both ORR activity and stability.

Creating Asymmetric Fe-NC-N Sites in Single-Atom Catalysts Boosts Catalytic Performance for Oxygen Reduction Reaction.

Fine tuning of the metal site coordination environment of a single-atom catalyst (SAC) to boost its catalytic activity for oxygen reduction reaction (ORR) is of significance but challenging. Herein, we report a new SAC bearing Fe-NC-N sites with asymmetric in-plane coordinated Fe-NC and axial coordinated N atom for ORR, which was obtained by pyrolysis of an iron isoporphyrin on polyvinylimidazole (PVI) coated carbon black. The C@PVI-(NCTPP)Fe-800 catalyst exhibited significantly improved ORR activity ( = 0.

Enhancing oxygen reduction activity of dinuclear copper complexes loaded on an N-doped carbon support a low-temperature pyrolysis strategy.

Bioinspired by the active sites of multicopper oxidases (MCOs), bi/multinuclear copper complexes have attracted great attention in promoting catalytic activity for the oxygen reduction reaction (ORR). Herein, we report the preparation of a Cu-N-C electrocatalyst Cu-BPOZ@CNB-400 for efficient ORR, which was obtained by low temperature pyrolysis of a dinuclear 2,5-bis(2-pyridyl)-1,3,4-oxadiazole (BPOZ) copper complex loaded on a N-doped carbon support at 400 °C. Cu-BPOZ@CNB-400 exhibited a half-wave potential () of 0.

Coordination polymer derived Fe-N-C electrocatalysts with high performance for the oxygen reduction reaction in Zn-air batteries.

Developing high performance noble-metal-free electrocatalysts as an alternative to Pt-based catalysts for the oxygen reduction reaction (ORR) in energy conversion devices is highly desirable. We report herein the preparation of a coordination-polymer (CP)-derived Fe/CP/C composite as an electrocatalyst for the ORR with excellent activity and stability both in solution and in Zn-air batteries. The Fe/CP/C catalyst was obtained from the pyrolysis of an iron porphyrin Fe(TPP)Cl (5,10,15,20-tetraphenyl-21,23-porphyrin iron(III) chloride) grafted Zn-coordination polymer with dangling functional groups 4,4'-oxybisbenzoic acid and 4,4'-bipyridine ligands.

Vancomycin relieves tacrolimus-induced hyperglycemia by eliminating gut bacterial beta-glucuronidase enzyme activity.

Up to 40% of transplant recipients treated long-term with tacrolimus (TAC) develop post-transplant diabetes mellitus (PTDM). TAC is an important risk factor for PTDM, but is also essential for immunosuppression after transplantation. Long-term TAC treatment alters the gut microbiome, but the mechanisms of TAC-induced gut microbiota in the pathogenesis of PTDM are poorly characterized.

Intracellular tacrolimus concentration correlates with impaired renal function through regulation of the IS-AHR-ABC transporter in peripheral blood mononuclear cells.

Backgrounds: Tacrolimus (TAC) concentration in peripheral blood mononuclear cells (PBMCs) is regarded as a better predictor of its immunosuppressive effect than the TAC concentration in whole blood. However, whether the exposure of TAC in PBMCs or WB was altered in post-transplant recipients with renal impairment remains unclear.

Methods: We investigated the relationship of trough TAC concentration in WB and PBMCs with renal functions in post-transplant recipients.

Contracted Fe-N-C Sites in Single-Atom Catalysts Boosting Catalytic Performance for Oxygen Reduction Reaction.

Promoting the catalyst performance for oxygen reduction reaction (ORR) in energy conversion devices through controlled manipulation of the structure of catalytic active sites has been a major challenge. In this work, we prepared Fe-N-C single-atom catalysts (SACs) with Fe-N active sites and found that the catalytic activity of the catalyst with shrinkable Fe-N-C sites for ORR was significantly improved compared with the catalyst bearing normal Fe-N-C sites. The catalyst C@PVI-(TPC)Fe-800, prepared by pyrolyzing an axial-imidazole-coordinated iron corrole precursor, exhibited positive shifted half-wave potential ( = 0.

A P-doped PtNi alloy supported on N,C-doped TiO nanosheets as a stable electrocatalyst for the oxygen reduction reaction in an acidic electrolyte.

A P-doped PtNi alloy loaded on N,C-doped TiO nanosheets (P-PtNi@N,C-TiO) exhibited excellent activity and durability for the oxygen reduction reaction (ORR) in 0.1 M HClO solution with mass (4×) and specific (6×) activity several times higher than those of commercial 20 wt% Pt/C, respectively. The P dopant mitigated the dissolution of Ni and strong interactions between the catalyst and the N,C-TiO support inhibited catalyst migration.

Pharmacokinetics and bioequivalence evaluation of omeprazole and sodium bicarbonate dry suspensions in healthy Chinese volunteers.

Omeprazole and sodium bicarbonate dry suspension are effective treatments for acid-related disorders. This study compared the bioequivalence and safety of the two formulations of omeprazole and sodium bicarbonate powder and assessed how CYP2C19 gene polymorphisms affect pharmacokinetics (PK). A single-center, randomized, single-dose, 2-sequence and 2-period crossover method was performed in forty healthy Chinese subjects.

Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats.

Background: Intestinal microbiota has been confirmed to influencing the pharmacokinetic processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut microbiota on cyclosporine A, a drug with a narrow therapeutic window, remain to be studied.

Method: Twenty-one rats were randomly divided into three groups: (a) control group (CON), (b) antibiotic treatment group (ABT) and (c) fecal microbe transplantation group (FMT).

A Pharmacokinetic Drug-Drug Interactions Study between Entecavir and Hydronidone, a Potential Novel Antifibrotic Small Molecule, in Healthy Male Volunteers.

Introduction: Hepatic fibrosis is an inevitable process of hepatic sclerosis, malignancy, and insufficiency, and hydronidone is an innovative antifibrosis drug. This study focus on the pharmacokinetic interaction of hydronidone and entecavir in healthy Chinese male subjects.

Methods: An open-label, three-period, multiple-dosage, self-controlled clinical trial was executed in 12 healthy male subjects.

A novel, simple and reliable method for the determination of hydronidone and its metabolites M3 and M4 in human plasma and urine by HPLC-MS/MS and its application to a pharmacokinetic study in health Chinese subjects.

In this study, a novel, simple and reliable high-performance liquid chromatography with tandem mass spetrometry method (HPLC-MS/MS) was developed for the determination of hydronidone and its metabolites M3 and M4 in human plasma and urine so as to study the clinical pharmacokinetics of hydronidone. By effectively inhibiting the proliferation of hepatic stellate cells (HSC), hydronidone can reduce collagen synthesis and curbs the process of liver fibrosis, and is currently in the stage of clinical research for anti-liver fibrosis. Hydronidone and its metabolites M3, M4 were extracted from human plasma by protein precipitation, and the urine samples were directly diluted with acetonitrile and analyzed by HPLC-MS/MS.

Mechanism study of CoS/Fe(III)/peroxymonosulfate catalysis system: The vital role of sulfur vacancies.

Peroxymonosulfate (PMS) activation methods have attractive advantages in advanced oxidation process (AOPs) due to their powerful ability of directly or indirectly generating various reactive oxygen species (ROS). Herein, trace amount of Fe(III) ions were added into the commercial-CoS/PMS system to improve the CoS/PMS decomposition for organics removal. The organics removal efficiency could reach >90% towards methylene blue (MB), diclofenac sodium (DCF), sulfamethoxazole (SMX) and bisphenol A (BPA) in the CoS/Fe(III)/PMS system, with the kinetic apparent rate constant k of 0.

The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy.

Objective: Plant-derived cytotoxic transgene expression, such as trichosanthin (tcs), regulated by recombinant adeno-associated virus (rAAV) vector is a promising cancer gene therapy. However, the cytotoxic transgene can hamper the vector production in the rAAV producer cell line, human embryonic kidney (HEK293) cells. Here, we explored microRNA-122 (miR122) and its target sequence to limit the expression of the cytotoxic gene in the rAAV producer cells.

Axial Ligand Coordination Tuning of the Electrocatalytic Activity of Iron Porphyrin Electrografted onto Carbon Nanotubes for the Oxygen Reduction Reaction.

The oxygen reduction reaction (ORR) is essential in many life processes and energy conversion systems. It is desirable to design transition metal molecular catalysts inspired by enzymatic oxygen activation/reduction processes as an alternative to noble-metal-Pt-based ORR electrocatalysts, especially in view point of fuel cell commercialization. We have fabricated bio-inspired molecular catalysts electrografted onto multiwalled carbon nanotubes (MWCNTs) in which 5,10,15,20-tetra(pentafluorophenyl) iron porphyrin (iron porphyrin FeF TPP) is coordinated with covalently electrografted axial ligands varying from thiophene to imidazole on the MWCNTs' surface.

Non-symbolic and symbolic number lines are dissociated.

People use mental number lines for both symbolic numerals and numerosity, but little is known about how these two mental number lines are related. The current study investigated the association in effect size, directionality of the mental number line, and development between symbolic and non-symbolic mental number lines to determine if they were related to or independent from each other. We collected data from numerosity- and digit-matching tasks that used the following numbers: 11, 14, 17, 20, 23, 26, and 29.

Author Response to Comment on: Dynamic Adsorption of Sulfamethoxazole from Aqueous Solution by Lignite Activated Coke.

The authors would like to thank the comment by Diego M. Juela for contributing to helpful scientific discussions and correction suggestions, and to also express thanks to the editors.

[Empirical and experiential analysis of pre-hospital coronavirus disease 2019 epidemic emergency care resource allocation and usage in Jinan].

Objective: To find effective methods to improve the distribution and usage efficiency of pre-hospital epidemic emergency care resource (PEECR) by analyzing the PEECR allocation and usage in Jinan City during the coronavirus disease 2019 (COVID-19) epidemic.

Methods: Correlation significance test between the COVID-19 epidemiology sample and the PEECR allocation sample was conducted to estimate whether they came from the same population in Jinan from January 24 to June 30, 2020. The data used in empirical analysis were collected from the Health Commission of Shandong Province's daily epidemic information announcement (definite case increment, suspected case increment, suspected case stock, medical observation stock, close contact increment) and interview with some epidemic branch centers in Jinan City (vehicle using increment).

Dynamic Adsorption of Sulfamethoxazole from Aqueous Solution by Lignite Activated Coke.

In this paper, lignite activated coke was used as adsorbent for dynamic column adsorption experiments to remove sulfamethoxazole from aqueous solution. The effects of column height, flow rate, initial concentration, pH and humic acids concentration on the dynamic adsorption penetration curve and mass transfer zone length were investigated. Results showed penetration time would be prolonged significantly by increasing column height, while inhibited by the increasement of initial concentration and flow rate.

Stabilizing Effects on a Cd Polluted Coastal Wetland Soil using Calcium Polysulphide.

In this study, different dosages of calcium polysulphide (CaS) were used as an amendment to investigate effects on the immobilizing of Cd in a wetland soil by pot experiment. In addition to chemical analysis (pH and bioavailable Cd concentration), changes in soil enzyme activities, microbial carbon utilization capacity, metabolic and community diversity were examined to assess dynamic impacts on soil environmental quality and toxicity of Cd resulting from ameliorant dosing. Soil pH increased immediately upon CaS amendment compared to the unamended control (CK), and then declined slowly to a level lower than CK.

Extraction of Induces Liver Cancer Apoptosis.

HCC is one of the fastest-rising causes of cancer-related death. Novel therapeutic approaches for treatment are warranted. The goal of this study is to find effective components from Chinese herbal medicines, which is an important alternative source of anticancer medicine.

Liposome Lipid-Based Formulation Has the Least Influence on rAAV Transduction Compared to Other Transfection Agents.

Recombinant adeno-associated virus (rAAV) vectors are considered ideal vehicles for human gene therapy. Meanwhile, non-viral strategies, such as transfection agents (TAs), have also shown promise to deliver genetic materials, such as siRNA. Transduction with the rAAV vector is performed concurrently with transfection with plasmid DNA or RNA.