Bioinformatics Approach to Identify the Pathogenetic Link of Gut Microbiota-Derived Short-Chain Fatty Acids and Ischemic Stroke.

Stroke is a life-threatening condition that impairs the arteries and causes neurological impairment. The incidence of stroke is increasing year by year with the arrival of the aging population. Thus, there is an urgent need for early stroke diagnosis.

Hispidulin exhibits neuroprotective activities against cerebral ischemia reperfusion injury through suppressing NLRP3-mediated pyroptosis.

Aim: Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function.

Hispidulin Protects Against Focal Cerebral Ischemia Reperfusion Injury in Rats.

Focal cerebral ischemia is associated with ischemia/reperfusion (I/R) injury. Hispidulin is a flavonoid compound with a variety of pharmacological properties. The neuroprotective effects of hispidulin have not been fully elucidated.

Milk fatty acid profiles in Holstein dairy cows fed diets based on corn stover or mixed forage.

In this study the influence of modulated concentrate-to-roughage ratio on the fatty acid profile of milk fat was investigated in dairy cows. Therefore, corn stover was compared with better-quality roughages. Two groups of in total 24 Holstein dairy cows (136 ± 37 days in milk) received either a high-forage diet (Diet MF, forage-to-concentrate ratio [F:C] = 60:40) with alfalfa hay, corn silage and Chinese wild rye as forage sources, or a low-forage diet with corn stover as forage source (Diet CS, F: C = 40:60) for an experimental period of nine weeks.