Publications by authors named "Pengjie Yu"
Article Synopsis
- - Gastric cancer (GC) is a common and serious condition that affects the stomach lining and has high rates of illness and death, making effective diagnosis and treatment crucial.
- - This study evaluated the treatment efficacy and safety of a chemotherapy regimen combining nab-paclitaxel with oxaliplatin and S-1 (P-SOX) compared to the standard SOX regimen in 219 patients with advanced GC over three years.
- - The results indicated that the P-SOX regimen provided better short-term and long-term outcomes than SOX, with manageable side effects, suggesting it could become a preferred first-line treatment for GC patients.
To explore the efficacy and safety of paclitaxel+oxaliplatin+S-1 (PSOX), docetaxel+oxaliplatin+fluorouracil (DOF) and oxaliplatin+S-1 (SOX) regimens as neoadjuvant chemotherapy for advanced gastric cancer (GC). A retrospective analysis was used in 306 patients with GC who underwent neoadjuvant chemotherapy, consisting of 102 from the PSOX group, 100 from the DOF group and 104 from the SOX group. The total effective rates and disease control rates for the PSOX, DOF and SOX groups were 31.
View Article and Find Full Text PDFGastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. In this study, we compared the clinicopathological features and prognosis of GC between young and old patients after curative resection. Six hundred and eighty-six patients with GC resected were divided two groups according to patient age: Younger GC patients ≤40 years of age (YGC, n = 52) and older GC patients >40 years of age (OGC, n = 634).
View Article and Find Full Text PDFObjective: To explore the application value of circulating tumor cells (CTCs) and circulating free DNA (cfDNA) from peripheral blood in the prognosis of advanced gastric cancer (AGC). Here, we measured CTCs and cfDNA quantity for predicting the outcome of patients. .
View Article and Find Full Text PDFPurpose: To explore the effects of WW domain-containing oxidoreductase (WWOX) gene methylation on proliferation and apoptosis of osteosarcoma cells.
Methods: A total of 51 patients with osteosarcoma confirmed by pathological examinations were enrolled as the observation group, while 49 cases with non-osteosarcoma diagnosed and treated in our hospital were randomly selected as the control group. Osteosarcoma cell lines MG63 and HOS were selected as observation group, while those added with methylation inhibitor were set as control group, of which genomic methylation level was determined via HPLC.
Inhibitory Effect of Crocin Against Gastric Carcinoma via Regulating TPM4 Gene.
Onco Targets Ther
January 2021
Background: Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities.
Methods: In this study, we investigated the inhibitory effect of crocin on gastric cancer AGS cells proliferation and explored the underlying mechanism.
Malignant acanthosis nigricans with Leser-Trélat sign and tripe palms: A case report.
World J Clin Cases
November 2020
Article Synopsis
- Acanthosis nigricans (AN), Leser-Trélat sign, and tripe palms are skin conditions that can indicate underlying health issues, particularly cancer.
- A case study details a 61-year-old man who developed these skin disorders alongside gastric cancer symptoms after treatment for Riehl's melanosis.
- The report highlights the importance of monitoring skin changes in patients, as they may signal serious conditions like cancer, emphasizing a connection between these skin diseases and malignant conditions.
Gastric cancer (GC) is the fourth most common cancer in the world and the second most common cancer in China. The aim of this study was to investigate the clinicopathologic profiles and prognosis of GC in the upper third (UT), middle third (MT) and low third (LT) of the stomach.Five hundred and forty-two patients with GC resected between January 2010 and January 2014 were retrospectively studied and divided in 3 groups according to cancer location: upper third gastric cancer (UTGC) (n = 62); MTGC (n = 131) and LTGC (n = 349).
View Article and Find Full Text PDFGastric cancer is the fourth most common cause of cancer death globally and the second most common in Asia. Many studies suggest that Crocin has the potential for gastric cancer antineoplastic combined chemotherapy protocols. Here we investigated genomic changes related to the inhibitory effect of Crocin, and elucidated the molecular mechanism of this inhibition in gastric carcinoma cells.
View Article and Find Full Text PDFBackground: Melanotic Xp11-associated tumors are rare mesenchymal-derived tumors. So far, most primary melanotic Xp11-associated tumors have been reported in the kidney, and reports of this tumor in the gastrointestinal tract are rare.
Case Summary: Here we describe the case of a 25-year-old woman who presented with a melanotic Xp11-associated tumor in the sigmoid colon.
Objective: The incidence of gastric cancer is high in Chinese Tibetan. This study aimed to identify the differentially expressed microRNAs (miRNAs) and further explore their potential roles in Tibetan with gastric cancer so as to predict potential therapeutic targets.
Methods: A total of 10 Tibetan patients (male:female = 6:4) with gastric cancer were enrolled for isolation of matched gastric cancer and adjacent non-cancerous tissue samples.