Protocol for iron-catalyzed cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides.

Organochlorides are a crucial class of electrophiles in organic synthesis. Here, we present a protocol for the cross-electrophile coupling of aryl chlorides with unactivated alkyl chlorides, facilitated by an iron/Bpin catalytic system. We describe steps for the coupling of aryl chlorides with alkyl chlorides, followed by purification of products.

Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities.

The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species.

A new fusicoccane diterpene and a new polyene from the plant endophytic fungus and their antimicrobial activities.

A new fusicoccane diterpene, pinophicin A (, and a new polyene, pinophol A (), were isolated from the plant endophytic fungus obtained from the aerial parts of . The structures and relative configurations of - were determined by the analysis of extensive spectroscopic data, chemical method, and comparison with known compounds. Compound exhibited weak antibacterial activity against B with an MIC value of 50 μg/mL.

Two New Prenylated Indole Diterpenoids from Tolypocladium sp. and Their Antimicrobial Activities.

Two new prenylated indole diterpenoids, tolypocladins K and L (1 and 2), together with a known analog terpendole L (3), were isolated from the solid fermentation culture of a mine soil-derived fungus Tolypocladium sp. XL115. Their structures and relative configurations were determined by comprehensive spectroscopic data analysis, as well as by comparison of their NMR data with those related known compounds.

Emericellins A and B: Two sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold from the liquid cultures of endophytic fungus Emericella sp. XL 029.

Two novel sesquiterpenoids with an unprecedented tricyclo[4,4,2,1]hendecane scaffold, namely emericellins A (1) and B (2) representing a new skeleton, were isolated from the liquid cultures of an endophytic fungus Emericella sp. XL 029 associated with the leaves of Panax notoginseng. Their structures and relative configurations were characterized by extensive spectroscopic methods.

Genome-wide identification and characterization of odorant-binding protein (OBP) genes in the malaria vector Anopheles sinensis (Diptera: Culicidae).

Anopheles sinensis is a major malaria vector. Insect odorant-binding proteins (OBPs) may function in the reception of odorants in the olfactory system. The classification and characterization of the An.