Publications by authors named "Penghe Wang"

Background: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disorder. Diet is recognized as a modifiable factor that may influence inflammation and potentially accelerate RA progression. Nevertheless, the effects of diverse dietary patterns and their combined impact on RA progression and long-term mortality remain inadequately understood.

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In the genesis and progression of cardiovascular and metabolic diseases (CVMDs), adipose tissue plays a pivotal and dual role. Complement factor D (CFD, also known as adipsin), which is mainly produced by adipocytes, is the rate-limiting enzyme of the alternative pathway. Abnormalities in CFD generation or function lead to aberrant immune responses and energy metabolism.

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Doxorubicin (DOX) is an effective anticancer agent, but its clinical utility is constrained by dose-dependent cardiotoxicity, partly due to cardiomyocyte ferroptosis. However, the progress of developing cardioprotective medications to counteract ferroptosis has encountered obstacles. Protosappanin A (PrA), an anti-inflammatory compound derived from hematoxylin, shows potential against DOX-induced cardiomyopathy (DIC).

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The treatment of sepsis caused by multidrug-resistant (MDR) Gram-negative bacterial infections remains challenging. With these pathogens exhibiting resistance to carbapenems and new generation cephalosporins, the traditional antibiotic polymyxin B (PMB) has reemerged as a critical treatment option. However, its severe neurotoxicity and nephrotoxicity greatly limit the clinical application.

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  • Polymyxin B and E (colistin) are critical last-resort antibiotics against multidrug-resistant Gram-negative bacteria, but resistance to them is escalating, posing a significant public health risk.
  • A new polymyxin S has been developed, showing stronger antibacterial effects and lower toxicity compared to existing options.
  • Research on a resistant mutant (Mut-S) revealed a large-scale genomic inversion as a mechanism for resistance, similar to those observed in mutants resistant to polymyxin B and colistin, highlighting bacterial adaptability to antibiotics.
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  • Sepsis is a serious global health issue with high mortality rates, prompting research into the novel drug candidate ASK0912 for its protective effects during sepsis caused by Acinetobacter baumannii in mice.!
  • The study found that ASK0912 significantly improved survival rates, maintained body temperature, reduced bacterial loads, and prevented organ damage in septic mice administered a low dose of 0.6 mg/kg.!
  • Additionally, ASK0912 reduced elevated cytokine levels, thereby mitigating inflammation and supporting better immune response in sepsis-affected mice, highlighting its potential as a treatment option.!
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Objectives: Contezolid acefosamil is a novel O-acyl phosphoramidate prodrug of contezolid. In the current study, we aimed to systemically evaluate the efficacy of contezolid acefosamil against infections caused by multiple Gram-positive pathogens, and compare the efficacy of the prodrug by oral and intravenous administrations.

Methods: The in vivo pharmacodynamic efficacy of contezolid acefosamil was evaluated in mouse models of systemic (with five S.

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The ability to maintain redox homeostasis is critical for Mycobacterium tuberculosis () to survive the redox stress of the host. There are many antioxidant systems in to ensure its normal replication and survival in the host, and cysteine thiols are one of them. S-sulfenylation is one of the reversible modifications of cysteine thiols to resist oxidative stress.

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Antivirulence strategy has been developed as a nontraditional therapy which would engender a lower evolutionary pressure toward the development of antimicrobial resistance. However, the majority of the antivirulence agents currently in development could not meet clinical needs due to their narrow antibacterial spectrum and limited indications. Therefore, our main purpose is to develop broad-spectrum antivirulence agents that could target on both Gram-positive and Gram-negative pathogens.

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Isoproterenol (ISO) is widely used to treat bronchial asthma, cardiogenic or septic shock, complete atrioventricular block, and cardiac arrest. However, it can also cause myocardial damage owing to infarct-like necrosis. Curdione, an extract of the Chinese herb , has a variety of pharmacological activities, including cardioprotective effects.

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Background: Haemophilic arthropathy (HA), a common complication of haemophilia, is secondary to recurrent joint bleeding and increases the prevalence of end-stage osteoarthritis (OA). Total knee arthroplasty (TKA) is a reliable treatment for haemophilia patients. This study was performed to evaluate the mid-term outcomes of TKA for end-stage HA.

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Article Synopsis
  • The study aimed to compare the outcomes of unilateral total knee arthroplasty (TKA) performed in two different time periods: the "Si hour-period" (9:00 a.m. to 11:00 a.m.) and the "Wei hour-period" (1:00 p.m. to 3:00 p.m.).
  • Results indicated that surgeries conducted during the Si hour-period resulted in significantly lower total blood cell loss, hidden blood loss, visible blood loss, and maximum hemoglobin drop compared to the Wei hour-period.
  • The findings suggest that performing TKA in the Si hour-period may enhance platelet counts and reduce blood loss, although other postoperative complications and secondary outcomes were
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  • Femorotibial mechanical axis (FTMA) is crucial for successful total knee arthroplasty (TKA), with the ideal alignment considered to be neutral FTMA ± 3°, which improves joint function and longevity of prosthesis.
  • * Recent advancements in surgical technology have improved the accuracy of FTMA alignment, but there hasn't been a significant enhancement in clinical outcomes post-surgery.
  • * Some researchers argue that achieving neutral FTMA may not be necessary for better results, suggesting alternative alignment methods that consider patient-specific factors and other joint interactions can lead to improved clinical effects.
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Background: Infections caused by drug-resistant Staphylococcus aureus, especially vancomycin-intermediate Staphylococcus aureus (VISA), leave clinicians with limited therapeutic options for treatment. Persister cells is a leading cause of recalcitrant infection and antibiotic treatment failure, and there is no drug in clinical use that specifically targets persister cells currently. Here, we report a promising combination therapy of sodium new houttuyfonate (SNH) and berberine chloride (BBR) which is able to eradicate both growing and persistent drug-resistant Staphylococcus aureus.

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  • The study focused on the effectiveness of a specific macrophyte, (Blume) DC., in improving nitrogen removal in constructed wetlands, especially in cold temperatures below 10 °C.
  • Results showed that the presence of macrophytes increased ammonia nitrogen removal rates by 65%-71% and total nitrogen by 41%-48%, while also leading to a significant rise in chemical oxygen demand concentrations.
  • Planted systems demonstrated higher microbial diversity and abundance, including key nitrogen metabolism genes, suggesting that these microorganisms play a crucial role in enhancing nitrogen removal in wastewater treatment during winter.
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  • Hexokinase 2 (HK2) is an enzyme crucial for glycolysis that has higher levels in cancer cells, making it a significant target for cancer treatments.
  • Researchers used virtual screening to identify a new steroid from Ganoderma sinense, (22E,24R)-6β-methoxyergosta-7,9(11),22-triene-3β,5α-diol (compound 2), which showed strong binding affinity to HK2.
  • Compound 2, along with 12 related steroid analogues, underwent various tests and was confirmed as the first natural inhibitor of HK2, suggesting it could be a promising candidate for new cancer therapies.
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Numerous drought indices have been developed over the past several decades. However, few studies have focused on the suitability of indices for studies of ephemeral wetlands. The objective is to answer the following question: can the traditional large-scale drought indices characterize drought severity in shallow water wetlands such as the Everglades? The question was approached from two perspectives: the available water quantity and the response of wetland ecosystems to drought.

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  • The study investigates the impact of different plant species (Iris pseudacorus and Typha orientalis) on bacterial communities in subsurface flow constructed wetlands during winter in Eastern China.
  • It found that I. pseudacorus enhanced bacterial richness and diversity, especially increasing the abundance of nitrifying bacteria, while CWT showed less effectiveness.
  • The research concluded that I. pseudacorus significantly improved nitrogen removal rates compared to unplanted controls, likely due to root oxygen release even in low temperatures.
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  • The study examines the role of the cold-season aquatic plant Oenanthe clecumbens in enhancing effluent purification in constructed floating wetlands (CFWs) during winter.
  • Despite some leaf die-off, the plant's roots maintained high activity levels, contributing to nutrient removal even at low temperatures.
  • Although nitrogen (N) and phosphorus (P) removal efficiencies declined in winter compared to autumn, the presence of the cool-season macrophytes still improved N and P removal rates significantly.
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  • * An experiment was conducted to assess the impact of varying levels of sediment Cu and ammonia-N on the growth and health of Vallisneria natans, measuring factors like growth rate, biomass, and chlorophyll content.
  • * Results showed that increased sediment Cu reduced below-ground biomass, while higher ammonia-N levels significantly affected above-ground biomass, indicating that ammonia-N is more harmful than Cu. Additionally, elevated Cu levels worsened the negative effects of ammonia-N on these plants.
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