Proc AAAI Conf Artif Intell
March 2024
Utilizing electronic health records (EHR) for machine learning-driven clinical research has great potential to enhance outcome predictions and treatment personalization. Nonetheless, due to privacy and security concerns, the secondary use of EHR data is regulated, constraining researchers' access to EHR data. Generating synthetic EHR data with deep learning methods is a viable and promising approach to mitigate privacy concerns, offering not only a supplementary resource for downstream applications but also sidestepping the privacy risks associated with real patient data.
View Article and Find Full Text PDFExpert Opin Drug Metab Toxicol
September 2024
Background: The gene polymorphisms of the CYP2C9, as well as the substrate specificity of the enzyme, result in different clearances for different substrates by CYP2C9 variants.
Research Designand Methods: The CYP2C9 wild type and 38 CYP2C9 variants, expressed in insectmicrosomes, were incubated with azilsartan. The resulting metabolite,O-desethyl azilsartan, was determined by HPLC-MS/MS.
NLRP3 inflammasome plays an important role in autoimmunity and the dysregulation of NLRP3 inflammasome can lead to various human diseases. Natural products are an important source for the discovery of safe and effective inflammatory inhibitors. Chloranthalactone B (CTB), a lindenane sesquiterpenoid (LS) from a common traditional Chinese medicine (TCM) (Sarcandra glabra), could significantly inhibit the level of IL-1β.
View Article and Find Full Text PDFThe adsorption of per- and polyfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), is currently a critical issue in the environmental domain, yet it is not fully understood. Diamane, as a stable monolayer adsorbent, has garnered significant research interest. Defects and strain are reported to play a crucial role in regulating its electronic structure.
View Article and Find Full Text PDFThe Qinghai-Tibet Plateau (QTP) holds significance for investigating Earth's surface processes. However, due to rugged terrain, forest canopy, and snow accumulation, open-access Digital Elevation Models (DEMs) exhibit considerable noise, resulting in low accuracy and pronounced data inconsistency. Furthermore, the glacier regions within the QTP undergo substantial changes, necessitating updates.
View Article and Find Full Text PDFThe power transformer is the core equipment of the power system, a sudden failure of which will seriously endanger the safety of the power system. In recent years, artificial intelligence techniques have been applied to the dissolved gas analysis evaluation of power transformers to improve the accuracy and efficiency of power transformer fault diagnosis. However, most of the artificial intelligence techniques are data-driven algorithms whose performance decreases when the data are limited or significantly imbalanced.
View Article and Find Full Text PDFAccumulation of persistent organic pollutants polycyclic aromatic hydrocarbons (PAHs) in soil has become a global problem. Composting is considered one of the more economical methods of soil remediation and is important for the resourceful use of wastes. Agroforestry waste is produced in huge amounts and is utilized at low rates, hence there is an urgent need to manage it.
View Article and Find Full Text PDFSustainable elastomers derived from renewable biobased resources with excellent mechanical properties and varied functions are highly pursued to substitute traditional petroleum-based polymers yet challenging due to their limited macroscopic performance. In this work, we designed a series of wholly biobased cellulose-graft-poly(vanillin acrylate-co-tetrahydrofurfuryl acrylate) (Cell-g-P(VA-co-THFA) copolymer elastomers with cellulose as the rigid backbone, sustainable VA derived from lignin and soft THFA derived from hemicellulose as the hard and soft segments in the rubbery side chains. Moreover, the grafted side chains can be cross-linked to introduce an additional dynamic network structure via Schiff-base chemistry between the aldehyde and amino groups.
View Article and Find Full Text PDFCovering: 1925 to July 2023Among the sesquiterpenoids with rich structural diversity and potential bioactivities, lindenane sesquiterpenoids (LSs) possess a characteristic , -3,5,6-carbocyclic skeleton and mainly exist as monomers and diverse oligomers in plants from the genus and Chloranthaceae family. Since the first identification of lindeneol from in 1925, 354 natural LSs and their oligomers with anti-inflammatory, antitumor, and anti-infective activities have been discovered. Structurally, two-thirds of LSs exist as oligomers with interesting skeletons through diverse polymeric patterns, especially Diels-Alder [4 + 2] cycloaddition.
View Article and Find Full Text PDFSince the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-desmethyltramadol in Sprague-Dawley (SD) rats and the inhibitory effects of apatinib on tramadol in rat liver microsomes (RLMs), human liver microsomes (HLMs) and recombinant human CYP2D6.1.
View Article and Find Full Text PDFThe mineralization of organic components releases CO during composting, which not only leads to the loss of organic carbon, but has a direct negative impact on the environment. Malonic acid as a competitive inhibitor of succinate dehydrogenase could affect the tricarboxylic acid (TCA) cycle and reduce CO emissions. However, the bacterial interaction and organic component transformation has less known how to malonic acid reduce CO and improve of humus synthesis in complex composting.
View Article and Find Full Text PDFBackground: This study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and isavuconazole in rats.
Methods: A protein precipitation method using acetonitrile was used to prepare plasma samples using ibrutinib as an internal standard. Chromatographic separation and mass spectrometric detection of the analytes and internal standards were performed on a Shimadzu 8040 UHPLC‒MS/MS equipped with a Shim-pack velox C18 column (2.
Photosensitive materials, such as energetic complexes, usually have high sensitivity and cause heavy-metal pollution, whereas others, like carbon black and dye, do not contain energy, which affects energy output and mechanical properties. In this work, donor-acceptor π-conjugated energetic catalysts, denoted as D-n, are designed and synthesized. Nonmetallic hybrid energetic composites are prepared by assembling the as-synthesized catalysts into multiscale ammonium perchlorate (AP).
View Article and Find Full Text PDFPolycyclic aromatic hydrocarbons (PAHs) are a cluster of highly hazardous organic pollutants that are widespread in ecosystems and threaten human health. Composting has been shown to be an effective strategy for PAHs degredation. Here, we used Comamonas testosteroni as an inoculant in composting and investigated the potential mechanisms of PAHs degradation by co-occurrence network and structural equation modelling analysis.
View Article and Find Full Text PDFSolar water purification technology is one of the most potent methods to obtain freshwater due to its low cost and non-polluting characteristics. However, the purification efficiency is limited by the high ion concentration, organic pollution, and biological pollution during the actual water purification process. Here, we report a porous hydrogel membrane (Fe/TA-TPAM) for the purification of high ion concentration and contaminated water.
View Article and Find Full Text PDFThe penetration of external stimuli (microorganisms, ions, etc.) following to the pore is the key reason for the deterioration of cement and concrete structures. Although the traditional methods such as improving the chemical composition of cement and concrete materials can delay the erosion rate, the inevitable pore structure still makes its deterioration a challenge.
View Article and Find Full Text PDFCompared to the widely concerned azo bridges (-NN-), triazene bridges (-NN-NH-) with longer nitrogen chains are also favorable linking units leading to novel energetic materials. In this work, a new family of nitrogen-rich nitrotriazolate-based energetic compounds with a triazene bridge were synthesized and well characterized. The experimental results indicated that most of these new compounds have good thermal stabilities and low sensitivities.
View Article and Find Full Text PDFWith the dramatically increased environmental problems, the rational design of sustainable polymers from renewable feedstocks opens new avenues to reduce the huge pollution impact. The major challenge for sustainable polymers is the decreased mechanical performance compared to that of petroleum-based materials. In this work, fully biobased sustainable elastomers were developed by integrating renewable chitin, lignin, and plant oil into one macromolecule, in which chitin was chosen as the rigid backbone, while a lignin-derived monomer vanillin acrylate (VA) and a plant oil-based monomer lauryl acrylate (LA) were selected as the hard and soft segments for the grafted side chains.
View Article and Find Full Text PDFBladder cancer, one of the most prevalent malignant cancers, has high rate of recurrence and metastasis. Owing to genomic instability and high-level heterogeneity of bladder cancer, chemotherapy and immunotherapy drugs sensitivity and lack of prognostic markers, the prognosis of bladder cancer is unclear. Necroptosis is a programmed modality of necrotic cell death in a caspase-independent form.
View Article and Find Full Text PDFBladder cancer (BC) ranks the tenth in the incidence of global tumor epidemiology. LncRNAs and cuproptosis were discovered to regulate the cell death. Herein, we downloaded transcriptome profiling, mutational data, and clinical data on patients from The Cancer Genome Atlas (TCGA).
View Article and Find Full Text PDFBackground: Bladder cancer (BC) is one of the most common malignancies of the genitourinary system. Animal models offer an important tool to explore tumour initiation, progression, and therapeutic mechanisms. Our aim is to construct an optimized orthotopic BC model which is predictable, reproducible, and convenient.
View Article and Find Full Text PDFHydrogels with soft and wet properties have been intensively investigated for chronic disease tissue repair. Nevertheless, tissue engineering hydrogels containing high water content are often simultaneously suffered from low porous size and low water-resistant capacities, leading to undesirable surgery outcomes. Here, a novel sponge-like macro-porous hydrogel (SM-hydrogel) with stable macro-porous structures and anti-swelling performances is developed via a facile, fast yet robust approach induced by Ti C MXene additives.
View Article and Find Full Text PDFAlmonertinib was approved for the first-line treatment of advanced NSCLC patients with EGFR-TKI-sensitive genetic mutations by National Medical Products Administration (NMPA) in 2021.The purpose of this study was to establish and validate a fast, accurate, stable and facile ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of almonertinib in rat plasma, it was employed to explore the effect of Paxlovid on the pharmacokinetics of almonertinib in rats. Zanubrutinib was used as an internal standard (IS), and the plasma samples were prepared by the protein precipitation method using acetonitrile.
View Article and Find Full Text PDFA phytochemical investigation on the roots of Hypericum beanii resulted in the isolation of six new polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperberlones A-F, along with fourteen known analogues. The structural characterization of these compounds was carried out by analyzing the HRESIMS data, 1D and 2D NMR spectroscopic data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations. Hyperberlone A (1) was a caged PPAP with a rare tricyclo[4.
View Article and Find Full Text PDF