A Modified Critical Nitrogen Dilution Curve for Winter Wheat to Diagnose Nitrogen Status Under Different Nitrogen and Irrigation Rates.

The accuracy of nitrogen (N) diagnosis is essential to improve N use efficiency. The standard critical N concentration (standard N) dilution curves, an expression of the dynamics of N uptake and dry matter accumulation in plants, are widely used to diagnose the N status of crops. Several standard N dilution curves were proposed and validated for several crops, based on experiments involving different N fertilizer treatments.

Multidimensional intervention in individuals with mild cognitive impairment: a pilot nonrandomized study.

Background: There is an increasing need for non-pharmacological treatments that can enhance the cognitive function of individuals with mild cognitive impairment. We firstly performed multidimensional intervention based on the concept of the International Classification of Functioning, Disability and Health, and aimed to explore its short-term effect on the improvement of cognitive function in individuals with mild cognitive impairment.

Methods: Twenty-four individuals with mild cognitive impairment in this pilot study were recruited from the memory clinic and neurology ward in Shanghai Tenth People's Hospital from August 2018 to August 2019.

New insights into trace elements in the water cycle of a karst-dominated glacierized region, southeast Tibetan Plateau.

Trace elements (TEs) in water are crucial parameters for assessing water quality. However, detailed studies are limited on TEs in the hydrological system of the Tibetan plateau (TP). Here, we sampled snow, river water, and groundwater in Yulong Snow Mountain (Mt.

Flame-Retardant Textile-Based Triboelectric Nanogenerators for Fire Protection Applications.

Textile-based triboelectric nanogenerators (T-TENGs), combining the functions of energy harvesting and self-powered sensing with advantages of breathability and flexibility, have received intensive attention, which is vital to the rapid advancements in smart textiles. However, there exists few reports of T-TENGs applied to fires under the intelligent era of high requirements for devices with versatility and multiscenario practicability. Here, in combination with flame-retardant conductive cotton fabric, polytetrafluoroethylene-coated cotton fabric, and a divider, a low-cost and environmentally friendly flame-retardant textile-based triboelectric nanogenerator (FT-TENG) is developed, which is endowed with excellent fire resistance and outstanding energy harvesting capabilities.

Flexural Properties and Microstructure Mechanisms of Renewable Coir-Fiber-Reinforced Magnesium Phosphate Cement-Based Composite Considering Curing Ages.

As a renewable natural plant fiber, Coir fiber (CF) can be used to as an alternative to improve poor toughness and crack resistance of magnesium phosphate cement (MPC), replacing such artificial fibers as steel fiber and glass fiber and thereby reducing huge energy consumptions and large costs in artificial fibers' production and waste treatment. Aiming at examining the effects of CF volume concentrations on MPC flexural properties, this study employed a typical three-point bending test, including thirty cuboid specimens, to investigate the flexural strength, load-deflection behavior, and flexural toughness of MPC with different CF volume concentrations from 0% to 4% at the curing age of seven days and 28 days. Results demonstrated that CF presented similar effects on MPC's properties at two curing ages.

A Spatiotemporal Deep Learning Approach for Unsupervised Anomaly Detection in Cloud Systems.

Anomaly detection is a critical task for maintaining the performance of a cloud system. Using data-driven methods to address this issue is the mainstream in recent years. However, due to the lack of labeled data for training in practice, it is necessary to enable an anomaly detection model trained on contaminated data in an unsupervised way.

Smart Nanosacrificial Layer on the Bone Surface Prevents Osteoporosis through Acid-Base Neutralization Regulated Biocascade Effects.

Osteoporosis is a global chronic disease characterized by severe bone loss and high susceptibility to fragile fracture. It is widely accepted that the origin acidified microenvironment created by excessive osteoclasts causes irreversible bone mineral dissolution and organic degradation during osteoclastic resorption. However, current clinically available approaches are mainly developed from the perspective of osteoclast biology rather than the critical acidified niche.

Immunosuppressive and metabolic agents that influence allo- and xenograft survival by in vivo expansion of T regulatory cells.

The transplanted organs or cells survive if the recipient receives adequate long-term immunosuppressive therapy. Immunosuppressive therapy combined with cell-based strategies (eg, regulatory T cell [Treg]-based therapy) promotes graft survival. A combination of Treg-based therapy and minimal or no immunosuppressive drug therapy would have the potential to minimize the risks of the complications and side effects of these drugs.

Evaluation of immune efficacy of recombinant PRRSV vectored vaccine rPRRSV-E2 in piglets with maternal derived antibodies.

Currently live attenuated porcine reproductive and respiratory syndrome (PRRS) and classical swine fever (CSF) vaccines are widely used in Chinese swine herds. However, the mutual effects of vaccination procedures and severe stress caused by successive vaccinations harm piglets and make it difficult to stimulate robust and effective immune responses. In our previous study, a recombinant PRRS virus (PRRSV) vectored vaccine candidate rPRRSV-E2, which expresses CSF virus (CSFV) E2 protein, has been demonstrated being able to protect piglets against lethal challenge of highly-pathogenic (HP)-PRRSV and CSFV.

Post-Procedural Anticoagulation After Primary Percutaneous Coronary Intervention for Anterior Acute Myocardial Infarction With Severe Left Ventricular Dysfunction.

Background: Patients with anterior acute myocardial infarction (AMI) and left ventricular (LV) dysfunction have an increased risk of LV thrombus (LVT). In the thrombolytic era, short-term anticoagulation using low-molecular-weight heparin during hospitalization proved to significantly reduce LVT formation, but, the effect of this prophylactic approach remains unclear in the current era. Therefore, we conducted a study to evaluate the effects of post-procedural anticoagulation (PPAC) using enoxaparin in addition to dual antiplatelet therapy (DAPT) after primary percutaneous coronary intervention (PCI) in such patients.

The efficacy and safety of pioglitazone in psoriasis vulgaris: A meta-analysis of randomized controlled trials.

Pioglitazone may have potential benefits in the treatment of cutaneous and metabolic derangements of psoriasis, but its role in the treatment of psoriasis remains in debate. We therefore conducted a meta-analysis to evaluate the clinical efficacy and safety of pioglitazone in psoriasis vulgaris (PsV).We performed a comprehensive search in database of PubMed, Web of Science, Cochrane library, Embase and China National Knowledge Infrastructure (CNKI), and Wan fang database through March 2019 to identify eligible studies.

3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects.

Background: Osteoarthritis is the leading cause of disability worldwide; cartilage degeneration and defects are the central features. Significant progress in tissue engineering holds promise to regenerate damaged cartilage tissue. However, a formidable challenge is to develop a 3-dimensional (3D) tissue construct that can regulate local immune environment to facilitate the intrinsic osteochondral regeneration.

Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation.

Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells. A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs. Therefore, to achieve a transplantable organ in animals without rejection, creation of vascular endothelial cells derived from humans within the organ is necessary.

Sedimentary ancient DNA metabarcoding delineates the contrastingly temporal change of lake cyanobacterial communities.

Harmful cyanobacterial blooms consisting of toxic taxa can produce a wide variety of toxins to threaten water quality, ecosystem functions and services. Of greater concern was the changing patterns of cyanobacterial assemblage were not well understood due to the lack of long-term monitoring data over the temporal scale. Biodiversity change in cyanobacterial community and paleoenvironmental variables over the past 170 years in Lake Chenghai were investigated based on sedimentary ancient DNA metabarcoding and traditional paleolimnological analysis.

Association between admission systolic blood pressure and major adverse cardiovascular events in patients with acute myocardial infarction.

Background: Several studies have previously demonstrated that higher systolic blood pressure level means lower risk of adverse cardiovascular outcomes. However, there is a lack of further investigation into the nonlinear relationship between admission systolic blood pressure (SBP) and adverse outcomes of acute myocardial infarction (AMI) patients.

Objectives: The aim of this study was to investigate the specific relationship between admission SBP and incidence of major adverse cardiovascular events (MACE) in 30 days for AMI patients.

Alterations in the Ocular Surface Microbiome in Traumatic Corneal Ulcer Patients.

Purpose: Corneal ulcers are a common eye inflammatory disease that can cause visual impairment or even blindness if not treated promptly. Ocular trauma is a major risk factor for corneal ulcers, and corneal trauma in agricultural work can rapidly progress to corneal ulcers. This study aims to evaluate the changes in the ocular surface (OS) microbiome of patients with traumatic corneal ulcer (TCU).

Prediction of future carbon footprint and ecosystem service value of carbon sequestration response to nitrogen fertilizer rates in rice production.

There is concern for variations of the carbon footprint (CF) and ecosystem service value of carbon sequestration (ESVCS) related to nitrogen (N) fertilizer rate in rice production under future climate change. To explore possible future ecological effects of N fertilizer rate, a DeNitrification-DeComposition (DNDC) model combined with Representative Concentration Pathway (RCP) projections (RCP 4.5 and RCP 8.

A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer.

Our previous study indicated that intravenous vitamin C (IVC) treatment concurrent with modulated electrohyperthermia (mEHT) was safe and improved the quality of life (QoL) of non-small-cell lung cancer (NSCLC) patients. The aim of this trial was to further verify the efficacy of the above combination therapy in previously treated patients with refractory advanced (stage IIIb or IV) NSCLC. A total of 97 patients were randomized to receive IVC and mEHT plus best supportive care (BSC) (n = 49 in the active arm, receiving 1 g/kg * d IVC concurrently with mEHT, three times a week for 25 treatments in total) or BSC alone (n = 48 in the control arm).

Development of recycled polylactic acid/oyster shell/biomass waste composite for green packaging materials with pure natural glue and nano-fluid.

In this study, a diversified waste recycling system and a green processing technology are proposed. This research not only finds feasible solutions to alleviate environmental problems of plastic pollution and straw burning but also provides new reuse methods for oyster shell waste and hogwash oil. The developed noval biocomposite material is conducive to the green development of express industry.

Surgical or nonsurgical treatment for nontraumatic rotator cuff tears: Study protocol clinical trial.

Background: The optimal treatment for symptomatic, nontraumatic rotator cuff tear is unknown. The primary aim of this randomized controlled trial is to compare functional improvement after surgical and conservative treatment of nontraumatic rotator cuff tears.

Methods: This is a single-centre, randomized clinical trial with a follow-up of 12 months.

Association between Dix-Hallpike test parameters and successful repositioning maneuver in posterior semicircular canal benign paroxysmal positional vertigo: a case-control study.

Background: Nystagmus (i.e., involuntary eye movement) provoked by the Dix-Hallpike test (DHT) is considered the gold standard for diagnosing posterior semicircular canal benign paroxysmal positional vertigo (psc-BPPV).

Percutaneous coronary intervention in diabetic versus non-diabetic patients with prior coronary artery bypass grafting: a propensity score matching study.

Background: The target of this study was to explore the outcomes of percutaneous coronary intervention (PCI) in diabetic versus non-diabetic patients with prior coronary artery bypass grafting (CABG) surgery.

Methods: Seven hundred and twenty four patients who had previously received CABG and had been treated using PCI combined with drug-eluting stents (DES) between 2009 and 2017 were selected for a retrospective study and allocated into either a diabetes mellitus (DM) or non-diabetes mellitus (No DM) group. A 1:1 propensity score-matched evaluation was conducted and risk adjusted for analysis.

Design of double-slot antennas for terahertz array detectors in flip chip packaging.

In flip chip packaging, the performance of terahertz (THz) array detectors is directly influenced by the flip chip. In addition, predicting this effect is difficult because the readout circuits in the flip chip are very complex. In this study, to reduce the influence of the flip chip, we design a new type of double-slot antennas for THz array detectors.

Black carbon and mercury in the surface sediments of Selin Co, central Tibetan Plateau: Covariation with total carbon.

Tibetan Plateau (TP) is an important geographical region for investigating the long-range transport of pollutants as limited emission sources exist in this region. In this study, based on analysis of 61 surface samples, we report the spatial distribution and concentrations of BC, Hg, total organic carbon (TOC) and inorganic carbon (IC) in surface sediments of Selin Co, the largest lake in central Tibet. The mean BC and Hg concentrations were 0.

A new method for extraction of methanol-soluble brown carbon: Implications for investigation of its light absorption ability.

As an important component of organic carbon (OC), brown carbon (BrC) plays a significant role in radiative forcing in the atmosphere. Water-insoluble OC (WIOC) generally has higher light absorption ability than water-soluble OC (WSOC). The mass absorption cross-section (MAC) of WIOC is normally investigated by dissolving OC in methanol.