causes devastating rice blast disease, significantly impacting rice production in many countries. Among the many known resistance (R) genes, confers broad-spectrum resistance to isolates and encodes a nucleotide-binding site leucine-rich repeat receptor (NLR). Although Piz-t-interacting proteins and those in the signal transduction pathway have been identified over the last decade, the Piz-t-mediated resistance has not been fully understood at the transcriptomic and metabolomic levels.
View Article and Find Full Text PDFAs the core issue of physical chemistry, how to acquire, control, even adjust surface charging of colloidal particle is far from being completely understood. So poly(lauryl methacrylate) (PLMA) is first introduced with different chain lengths onto crude anatase titanium dioxide (TiO) nanoparticles (150-200 nm) through two-step surface modification. Along with rising basic nonionic polyisobutylene succinimide (PIBS) concentration, those modified TiO nanoparticles (TiO-NH-PLMA) with the low grafting amount (0.
View Article and Find Full Text PDFIn recent years, invasive fungal infections have posed a significant threat to human health, particularly due to the limited availability of effective antifungal medications. This study responds to the urgent need for powerful and selective antifungal agents by designing and synthesizing a series of lipopeptides with lipoylation at the N-terminus of the antimicrobial peptide I6. Compared to the parent peptide I6, lipopeptides exhibited selective antifungal efficacy in the presence of Na.
View Article and Find Full Text PDFAqueous batteries have become a promising means of energy storage due to its environmental friendliness. Nevertheless, it often exhibits limited energy density that hinder their application. Considering that ammonium ion (NH ) has a low mass and a small hydration radius, aqueous ammonium ion batteries (AAIBs) are expected to solve the problem of low energy density.
View Article and Find Full Text PDFThe alarming rise in global antimicrobial resistance underscores the urgent need for effective antibacterial drugs. Drawing inspiration from the bacterial-entrapment mechanism of human defensin 6, we have fabricated biomimetic peptide nanonets composed of multiple functional fragments for bacterial eradication. These biomimetic peptide nanonets are designed to address antimicrobial resistance challenges through a dual-approach strategy.
View Article and Find Full Text PDFSynbiotics, the combination of probiotics and prebiotics, are thought to be a pragmatic approach for the treatment of various diseases, including inflammatory bowel disease (IBD). The synergistic therapeutic effects of probiotics and prebiotics remain underexplored. , a short-chain fatty acid (SCFA) producer, has been recognized as a promising probiotic candidate that can offer health benefits.
View Article and Find Full Text PDF2D layered materials are regarded as prospective catalyst candidates due to their advantageous atomic exposure ratio. Nevertheless, the predominant population of atoms residing on the basal plane with saturated coordination, exhibit inert behavior, while a mere fraction of atoms located at the periphery display reactivity. Here, a novel approach is reported to attain complete atom activation in 2D layered materials through the construction of an interlayer biatomic pair bridge.
View Article and Find Full Text PDFThe increasing prevalence of multidrug-resistant bacterial infections necessitates the exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), have garnered extensive recognition as immunomodulatory molecules that leverage natural host mechanisms to enhance therapeutic benefits. The unique immune mechanism exhibited by certain HDPs that involves self-assembly into supramolecular nanonets capable of inducing bacterial agglutination and entrapping is significantly important.
View Article and Find Full Text PDFMolybdenum trioxide (MoO) has been widely studied in the energy storage field due to its various phase states and unique structural advantages. Among them, lamellar α-phase MoO (α-MoO) and tunnel-like h-phase MoO (h-MoO) have attracted much attention. In this study, we demonstrate that vanadate ion (VO) can transform α-MoO (a thermodynamically stable phase) to h-MoO (a metastable phase) by altering the connection of [MoO] octahedra configurations.
View Article and Find Full Text PDFGray scale consistency in pixels was extremely important for electrowetting displays (EWDs). However, traditional electrowetting display driving waveforms could not obtain a pixel aperture ratio consistency, which led to the occurrence of gray inconsistency even if it was the same driving waveform. In addition, the oil backflow caused by charge trapping could not be sustained.
View Article and Find Full Text PDFAs a representative of the new reflective display technology, electrowetting display (EWD) technology can be used as a video playback display device due to its fast response characteristics. Direct current (DC) driving brings excellent reflectivity, but static images cannot be displayed continually due to charge trapping, and it can cause afterimages when playing a dynamic video due to contact angle hysteresis. Alternating current (AC) driving brings a good dynamic video refresh ability to EWDs, but that can cause flickers.
View Article and Find Full Text PDFA three-color electrophoretic display (EPD) can solve the defect of an insufficient color display of black/white EPDs, but it is difficult to achieve a high red saturation due to the same driving polarity between black and red electrophoretic particles. In this work, a separation stage was proposed in the driving process to increase the red saturation in three-color EPDs. Firstly, red particles' motion was analyzed by the electrophoretic theory and Stokes' theorem to optimize driving parameters.
View Article and Find Full Text PDFThe electrowetting display (EWD) is a kind of reflective paper-like display. Flicker and grayscale distortion are caused by oil backflow, which is one of the important factors restricting the wide application of EWDs. The charge embedding caused by the electric field force in the dielectric layer is the cause of oil backflow.
View Article and Find Full Text PDFComput Methods Programs Biomed
June 2021
Background And Objectives: Cerebral microbleeds (CMBs) are cerebral small vascular diseases and are often used to diagnose symptoms such as stroke and dementia. Manual detection of cerebral microbleeds is a time-consuming and error-prone task, so the application of microbleed detection algorithms based on deep learning is of great significance. This study presents the feature enhancement technology applying to improve the performances of detecting CMBs.
View Article and Find Full Text PDFReceptor endocytosis is important for signal activation, transduction, and deactivation. However, how a receptor interprets conflicting signals to adjust cellular output is not clearly understood. Using genetic, cell biological, and pharmacological approaches, we report here that ERECTA-LIKE1 (ERL1), the major receptor restricting plant stomatal differentiation, undergoes dynamic subcellular behaviors in response to different EPIDERMAL PATTERNING FACTOR (EPF) peptides.
View Article and Find Full Text PDFBowman-Birk trypsin inhibitors (BBIs) play important roles in animal and plant immunity, but how these protease inhibitors are involved in the immune system remains unclear. Here, we show that the rice (Oryza sativa) BBI protein APIP4 is a common target of a fungal effector and an NLR receptor for innate immunity. APIP4 exhibited trypsin inhibitor activity in vitro and in vivo.
View Article and Find Full Text PDFElectrowetting has drawn significant interest because of the potential applications of displays, lab-on-a-chip microfluidic devices, electro-optical switches, and so forth. However, electrowetting display (EWD) is monostable, which needs extra continuous voltage supply to keep contracting the oil. This paper is concerned with the simulation of two-phase liquid flow in three-dimensional EWD pixels with two electrodes (E1 and E2) demonstrating bistability, where power is only needed to move the oil droplet between two stable states.
View Article and Find Full Text PDFMagnaporthe oryzae is an important fungal pathogen of both rice and wheat. However, how M. oryzae effectors modulate plant immunity is not fully understood.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
January 2019
The effect of annealing condition on microstructure, mechanical properties and springback behaviour was examined in the connection rod of Ti-6Al-4V alloy for spinal fixation devices. Compared with the deformed microstructure in the sample before annealing, relatively few equiaxed grains were present after annealing at 1003 K after 1.8 ks, and a considerable amount appeared at 7.
View Article and Find Full Text PDFProgrammed cell death (PCD) plays critical roles in plant immunity but must be regulated to prevent excessive damage. The E3 ubiquitin ligase SPL11 negatively regulates PCD and immunity in plants. We show that SPL11 cell-death suppressor 2 (SDS2), an S-domain receptor-like kinase, positively regulates PCD and immunity in rice by engaging and regulating SPL11 and related kinases controlling defense responses.
View Article and Find Full Text PDFBackground: Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic inflammatory disease in the lower gastrointestinal tract. Mounting evidence suggests that the predominance of the classically activated (M1) macrophages versus the alternatively activated (M2) macrophages plays a role in the progression of IBD. Thus, agents able to shift pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages may be beneficial to IBD.
View Article and Find Full Text PDFDisplays are ubiquitous in modern life, and there is a growing need to develop active, full color, video-rate reflective displays that perform well in high-light conditions. The core of display technology is to generate or manipulate light in the visible wavelength. Colored fluids or fluids with particles can be used to tune the light intensity (greyscale) or wavelength (colors) of reflective displays by different actuation methods.
View Article and Find Full Text PDFGenetic characterization of the Arabidopsis lesion simulating disease 1 (lsd1) mutant, a lesion mimic mutant (LMM), has revealed the essential role of AtLSD1 in the negative regulation of cell death and disease resistance. The three zinc-finger motifs found in AtLSD1 revealed a novel plant-specific gene family, whose members are significantly related to programmed cell death (PCD). In this study, we characterized a functional homologue to AtLSD1, TaLSD1, in the wheat-stripe rust fungus pathosystem.
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