Targeting endoplasmic reticulum stress-induced lymphatic dysfunction for mitigating bisphosphonate-related osteonecrosis.

Background: Bisphosphonates (BPs) are the first-line treatment to stop bone resorption in diseases, including osteoporosis, Paget's disease, multiple myeloma and bone metastases of cancer. However, BPs-related osteonecrosis of the jaw (BRONJ), characterized by local inflammation and jawbone necrosis, is a severe intractable complication. The cumulative inflammatory burden often accompanies impaired lymphatic drainage, but its specific impact on BRONJ and the underlying mechanisms remain unclear.

Realizing Dual-Mode Zinc-Ion Storage of Generic Vanadium-Based Cathodes via Organic Molecule Intercalation.

Intercalation engineering is a promising strategy to promote zinc-ion storage of layered cathodes; however, is impeded by the complex fabrication routes and inert electrochemical behaviors of intercalators. Herein, an organic imidazole intercalation strategy is proposed, where VO and NHVO (NVO) model materials are adopted to verify the feasibility of the imidazole intercalator in improving the zinc storage capabilities of vanadium-based cathodes. The intercalated imidazole molecules could not only expand interlayer spacing and strengthen structural stability by serving as extra "pillars" but also provide extra coordination sites for zinc storage via the coordination reaction between Zn and the C═N group.

The interplay of flow, self-efficacy, learning motivation, and learning outcomes in music education: A comprehensive analysis of multidimensional interactions.

This study innovatively investigates the interplay among flow, self-efficacy, learning motivation, and learning outcomes in music education, shedding light on the mediating and moderating mechanisms underlying these relationships. Employing Structural Equation Modeling (SEM), it analyzes data from 241 music students in the Guangdong region to empirically test the research hypotheses. The results reveal that flow not only directly predicts learning outcomes (β = 0.

Textured Asymmetric Membrane Electrode Assemblies of Piezoelectric Phosphorene and TiCT MXene Heterostructures for Enhanced Electrochemical Stability and Kinetics in LIBs.

Black phosphorus with a superior theoretical capacity (2596 mAh g) and high conductivity is regarded as one of the powerful candidates for lithium-ion battery (LIB) anode materials, whereas the severe volume expansion and sluggish kinetics still impede its applications in LIBs. By contrast, the exfoliated two-dimensional phosphorene owns negligible volume variation, and its intrinsic piezoelectricity is considered to be beneficial to the Li-ion transfer kinetics, while its positive influence has not been discussed yet. Herein, a phosphorene/MXene heterostructure-textured nanopiezocomposite is proposed with even phosphorene distribution and enhanced piezo-electrochemical coupling as an applicable free-standing asymmetric membrane electrode beyond the skin effect for enhanced Li-ion storage.

Implementing EMI in Chinese music classes: Students' perceived benefits and challenges.

Recognizing the opportunities and problems of using English as a medium of instruction (EMI) enables teachers, students, and educational administrators to capitalize on the opportunities and mitigate the problems. Considering this, many researchers worldwide have explored the opportunities and problems of EMI courses. Yet, the advantages and disadvantages of implementing EMI in Chinese academic contexts have rarely been investigated.

Hetero-Polycrystalline Membranes with Narrow and Rigid Pores for Molecular Sieving.

Molecular sieving membranes have great potential for energy-saving separations, but they suffer from permeability-selectivity trade-off limitation. In this report, simultaneous hetero-crystallization and hetero-linker coordination of metal-organic framework (MOF) hollow fiber membranes through one-pot synthesis for precise gas separation is reported. It is found that the hetero-polycrystalline membranes consist of 2D and 3D MOF phases and are defect-free and roughly orientated, hetero-linker exchange of 3D phase by larger geometric ones can narrow transport pathway, and framework rigidification occurs and thus fixes MOF channels.

Piezoelectric 1T Phase MoSe Nanoflowers and Crystallographically Textured Electrodes for Enhanced Low-Temperature Zinc-Ion Storage.

Transition metal dichalcogenides (TMDs) are regarded as promising cathode materials for zinc-ion storage owing to their large interlayer spacings. However, their capabilities are still limited by sluggish kinetics and inferior conductivities. In this study, a facile one-pot solvothermal method is exploited to vertically plant piezoelectric 1T MoSe  nanoflowers on carbon cloth (CC) to fabricate crystallographically textured electrodes.

LncRNA SNHG10 suppresses the development of doxorubicin resistance by downregulating miR-302b in triple-negative breast cancer.

Unlike other types of breast cancer, triple negative breast cancer (TNBC) does not respond to therapies targeting human epidermal growth factor receptor-2 (HER2) or hormone therapy, and the prognosis of patients with TNBC is usually poor. The role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 10 (SNHG10) has been investigated in many types of cancer, but its role in TNBC is unknown. This study aimed to explore the role of SNHG10 in TNBC in the context of doxorubicin treatment, a common therapy for TNBC.

Vapor-Phase Processing of Metal-Organic Frameworks.

ConspectusPorous metal-organic frameworks (MOFs), formed from organic linkers and metal nodes, have attracted intense research attention. Because of their high specific surface areas, uniform and adjustable pore sizes, and versatile physicochemical properties, MOFs have shown disruptive potential in adsorption, catalysis, separation, etc. For many of these applications, MOFs are synthesized solvothermally as bulk powders and subsequently shaped as pellets or extrudates.

Expansion and hazard risk assessment of glacial lake Jialong Co in the central Himalayas by using an unmanned surface vessel and remote sensing.

Glacial lake outburst floods (GLOFs) are a severe hazard in the Himalayas. Glacial lake expansion and the corresponding volume increase play major roles in GLOFs as well as climate change. Furthermore, mass movement and dam conditions play a major role in the GLOF initiation process.

Postsynthetic Modification of Metal-Organic Frameworks by Vapor-Phase Grafting.

A vapor-phase grafting strategy is developed for the postsynthetic modification of metal-organic frameworks (MOFs). On the basis of the Schotten-Baumann reaction between acyl chloride (-COCl) and amino (-NH) groups and hydrolysis of -COCl, the carboxylated MOFs could be prepared through simple exposure in vaporized acyl chloride molecules and immersion in water. The modified MOFs have well-maintained crystalline structures and porosities and show substantially improved fluoride removal performance.

Vapor-assisted self-conversion of basic carbonates in metal-organic frameworks.

Incorporation of nanoparticles has been considered as an efficient method for enhancing the adsorption performance of metal-organic frameworks (MOFs). Alkali metal compounds possess outstanding affinity to acidic CO2. In this study, a robust self-conversion strategy is reported for improving the carbon capture performance of MOFs, through directly transforming partial metal centers to basic carbonate (BC) nanoparticles.

The mixed application of organic and inorganic selenium shows better effects on incubation and progeny parameters.

This experiment aims to study the effects of dietary selenium (Se) sources on the production performance, reproductive performance, and maternal effect of breeder laying hens. A total of 2,112 Hyline brown breeder laying hens of 42 wk of age were selected and randomly divided into 3 groups, with 8 repeats in each group and 88 chickens per repeat. The sources of dietary Se were sodium selenite (SS, added at 0.

Chicken cecal DNA methylome alteration in the response to Salmonella enterica serovar Enteritidis inoculation.

Background: Salmonella enterica serovar Enteritidis (SE) is one of the pathogenic bacteria, which affects poultry production and poses a severe threat to public health. Chicken meat and eggs are the main sources of human salmonellosis. DNA methylation is involved in regulatory processes including gene expression, chromatin structure and genomic imprinting.

[Long-chain non-coding RNA MALAT1 regulates paclitaxel resistance of breast cancer cells by targeting miR-485-3p].

Objective: To investigate the role of long-chain non-coding RNA MALAT1 in modulating paclitaxel resistance in breast cancer cells.

Methods: Breast cancer SK-BR-3 cells were treated with gradient concentrations of paclitaxel to induce paclitaxel resistance of the cells. The resistant cells were transfected with si-NC, si-MALAT1, pcDNA, pcDNA-MALAT1, miRNC, miR-485-3p mimics, si-MALAT1+anti-miR-NC, or si-MALAT1+anti-miR-485-3p liposomes.

The correlated expression of immune and energy metabolism related genes in the response to Salmonella enterica serovar Enteritidis inoculation in chicken.

Background: Salmonella enterica serovar Enteritidis (SE) is one of the food-borne pathogenic bacteria, which affects poultry production and poses severe threat to human health. The correlation of immune system and metabolism in chicken after SE inoculation is important but not clear. In the current study, we identified the expression of immune and energy metabolism related genes using quantitative PCR to evaluate the correlation between immune system and energy metabolism against SE inoculation in Jining Bairi chicken.

MicroRNA-152 Inhibits Cell Proliferation, Migration, and Invasion in Breast Cancer.

The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in breast cancer cell lines.

Ultrathin metal-organic framework membrane production by gel-vapour deposition.

Ultrathin, molecular sieving membranes composed of microporous materials offer great potential to realize high permeances and selectivities in separation applications, but strategies for their production have remained a challenge. Here we show a route for the scalable production of nanometre-thick metal-organic framework (MOF) molecular sieving membranes, specifically via gel-vapour deposition, which combines sol-gel coating with vapour deposition for solvent-/modification-free and precursor-/time-saving synthesis. The uniform MOF membranes thus prepared have controllable thicknesses, down to ~17 nm, and show one to three orders of magnitude higher gas permeances than those of conventional membranes, up to 215.

Non-activation MOF arrays as a coating layer to fabricate a stable superhydrophobic micro/nano flower-like architecture.

Non-activation metal-organic framework (MOF) arrays are directly applied as a coating layer to fabricate a stable superhydrophobic micro/nano flower-like architecture. The MOF functionalized surfaces can be synthesized easily on different substrates without any activation procedure or modification by low free energy materials, which exhibit attractive performance in oil/water separation.

Transformation of metal-organic frameworks for molecular sieving membranes.

The development of simple, versatile strategies for the synthesis of metal-organic framework (MOF)-derived membranes are of increasing scientific interest, but challenges exist in understanding suitable fabrication mechanisms. Here we report a route for the complete transformation of a series of MOF membranes and particles, based on multivalent cation substitution. Through our approach, the effective pore size can be reduced through the immobilization of metal salt residues in the cavities, and appropriate MOF crystal facets can be exposed, to achieve competitive molecular sieving capabilities.

Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer.

Brain metastasis (BM) is a poor prognostic factor for non-small-cell lung cancer (NSCLC). Recent studies have shown that oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) were effective for BM from NSCLC with EGFR mutation. However, the relationship between EGFR mutations and prognosis of NSCLC BM patients remains to be determined.

Results of a randomized and controlled clinical trial evaluating the efficacy and safety of combination therapy with Endostar and S-1 combined with oxaliplatin in advanced gastric cancer.

Objectives: We aimed to evaluate the efficacy and safety of combination therapy of Endostar (recombinant human endostatin) and S-1 combined with oxaliplatin (SOX) in patients with advanced gastric cancer.

Methods: In this randomized, controlled trial, 165 late-stage gastric cancer patients were assigned to the experimental arm with Endostar in combination with SOX (80 patients) and the control arm with SOX alone (85 patients). The end points of this study included progression-free survival, response rate, and disease-control rate.